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7.4 Protecting the body – Questions and answers Q1. Bk Ch7 S7.5 Q1 a b Outline the difference between non-specific and specific defence mechanisms. When do non-specific defence mechanisms operate, compared with specific defence mechanisms? A1. Bk Ch7 S7.5 A1 a b Non-specific defence mechanisms do not target particular pathogens. They are defences that either stop pathogens from entering the body or a general response to the presence of a foreign agent in the body. Specific defence mechanisms involve the production of antibodies against particular pathogens. Non-specific defence mechanisms can be divided into first-line and second-line defences. Firstline defences include barriers such as the skin and mucous membranes as well as the action of cilia and chemical secretions from the stomach, vagina and urinary tract. These operate to keep pathogens from entering the body. Second-line defences include inflammation and phagocytosis. These methods operate once pathogens have managed to enter the body. Specific defence mechanisms also operate after entry of pathogens but, instead of mounting a general attack on any foreign invader, they target specific pathogens, producing antibodies to destroy them. Q2. Bk Ch7 S7.5 Q2 Explain what happens in the inflammatory response to help the body overcome invading pathogens. A2. Bk Ch7 S7.5 A2 During inflammation blood circulation to the affected area is increased. Blood vessels dilate and white blood cells can leak out of the blood vessels into the surrounding tissue where they engulf foreign materials, including cells and toxins. Histamines and prostaglandins produced by the damaged cells encourage the inflammatory response. Q3. Bk Ch7 S7.5 Q3 Complete the table summarising the defence barriers in the body. Defence barrier Location in body How defence barrier prevents entry of pathogens Skin Mucous membranes Cilia Chemical barriers Other secretions A3. Bk Ch7 S7.5 A3 Defence barrier Location in body How defence barrier prevents entry of pathogens Skin Covers body Physical barrier through which pathogens cannot usually penetrate Mucous membranes Digestive, respiratory, reproductive and urinary tracts Presence of antibody IgA in mucus reacts with pathogens, stopping them from penetrating through surface; lysozymes present—these 7.4 Protecting the body QA Copyright © Pearson Australia (a division of Pearson Australia Group Pty Ltd) page 1 of 2 are chemicals that break down the cell walls of some bacteria Cilia Respiratory passages As cilia beat together they sweep mucus and any foreign particles along, away from the lungs and towards the nasal passages and pharynx where they can be coughed out or swallowed Chemical barriers Stomach and small intestine Acidic environment of stomach and alkaline environment of small intestine usually destroy potential pathogens Other secretions Mouth, eyes, nasal passages Saliva, tears and nasal secretions contain lysozyme, a chemical that breaks down the cell walls of some kinds of bacteria Q4. Bk Ch7 S7.5 Q4 What is phagocytosis? What types of cells are responsible for this activity in the body? In what circumstances does this process occur? A4. Bk Ch7 S7.5 A4 Phagocytosis is the process in which specialised white blood cells called phagocytes engulf and destroy foreign particles such as pathogens. Phagocytosis occurs whenever foreign materials enter the blood or body tissues. Q5. Bk Ch7 S7.5 Q5 a b Is interferon an example of a non-specific or specific defence mechanism? How does interferon operate to control infection in the body? A5. Bk Ch7 S7.5 A5 a b Interferon is an example of a non-specific defence mechanism. Interferon is a protein that is produced by cells that have become infected by a virus. Once produced by infected cells the protein attaches to nearby healthy cells, preventing replication of the virus particles in those cells. Q6. Bk Ch7 S7.5 Q6 Define the term ‘antigen’. A6. Bk Ch7 S7.5 A6 An antigen is a molecule in the body that triggers an immune response, that is, the production of antibodies against a specific pathogen. 7.4 Protecting the body QA Copyright © Pearson Australia (a division of Pearson Australia Group Pty Ltd) page 2 of 2