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The Working Cell Energy, Homeostasis & Transport Ch 5 Interaction categories –Cell to external environment –Cell to cell The lipid bilayer • Fluid mosaic model Major functions of proteins Cell membrane Structure = Function • Phospholipid Bi-layer structure – Polar Phosphate head • Phosphate + glycerol group – Nonpolar fatty acid tails What may enter? • Depends on – Size – Polarity – concentration – Needs of cell Terms to know • Diffusion • Osmosis • Concentration gradient • Equilibrium 2 types of transport Movement is known as transport • Passive transport Examples: diffusion, osmosis, facilitated diffusion, gated channels • Active transport • Moves particles from low concentration to high • Up the concentration gradient • Cellular NRG (ATP) is required • Stops when cell has accomplished what it needs (not necessarily equilibrium) Ex: pumps, endocytosis (phago & pino), and exocytosis Passive transport examples… Gated channels & Facilitated diffusion – use solute-specific protein channels How do cells respond to environmental changes? What does osmosis look like in cells? Solutions – solute + solvent relative terms - hypertonic, hypotonic, isotonic Who’s THIRSTY? How cells deal with osmosis? osmoregulation • Too much fluid in – Turgid (plant cells) – Cytolysis (animal cells) • Too much fluid out – Plasmolysis (plant cells) – Crenate (animal cells) Cells can regulate what they bring in or excrete • Active transport – Ex: pumps, endocytosis (phago & pino), and exocytosis Big particles (use NRG) • Endocytosis –Pinocytosis –Phagocytosis • Exocytosis “Pumping ions” is like pumping iron • Sodium potassium pump • Proton (H+) pump Combinations of both… • Coupled channels - both types of transport – Glucose can diffuse (passive transport) into cell when attached to a sodium ion ( active transport) Homeostasis • Problems with organelles Pompe’s disease, TaySach’s, liver disease • Transport issues – endocrine system – Cholesterol, diabetes • Feedback mechanisms & enzyme regulation help maintain the balance Feedback Mechanisms