Download biophysical chemistry

BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE, PILANI
INSTRUCTION DIVISION
Course Handout (Part II)
In addition to part-I (General Handout for all courses appended to the timetable) this portion gives
further specific details regarding the course.
Course No.
Course Title
: BIO C331
: Biophysics
1. SCOPES AND OBJECTIVE:
The objective of the course is to introduce the students to the concepts of physical principles in the
biological and biomimetic molecular systems. Properties and conformations of biomolecules like
amino acids, proteins, nucleotides, nucleic acids as well as biomimetic systems like monolayers and
bilayers are to be discussed. Related physical phenomena in these systems like structural
transitions, protein folding, membrane equilibria are to be discussed. Emphasis will also be given to
understand the principles of major experimental techniques applied to understand these physical
problems.
2. Text Book: " Biophysical Chemistry”, EDD Lecture note, Nilashis Nandi, Published by EDD,
BITS, Pilani.
3. Reference Book : " Biophysical Chemistry, Part I, Part II and Part III", Charles R Cantor and
Paul R. Schimmel, W.H. Freeman and Co., New York.
4. Course Plan
Lec. Learning Objectives
No.
Understanding:
Topics to be covered
Ref.
to
Chap/Sec. T.B
Properties of amino acids
I
Primary structure of proteins
I
Intermolecular interactions
II
6,7
Chemical properties of basic
units of life
Lower level of structure of unit of
life
Basic interactions which drives
structures
Special interactions in biosystems
Hydrogen bonding and
hydrophobic Interaction
III, IV
8
Higher level structure
Tertiary Quaternary structure of V
proteins
9,10
Basic units of DNA, RNA
Nucleic acid
Properties of nucleotides
1,2
3
4,5
1
VI
11
Structure of nucleic acids
12,13 Biomimetic systems
14,15 Role of lipids
Lipids, monolayers and bilayers VII
Lipids in membranes and
Protein lipid interaction
16
Function of membranes
Membrane equilibria
VIII
17
Structure and Function
Chirality and recognition
IX
Liquid state theory
X
Conformation dependent
properties
Polypeptides
XI
Helix coil transitions
XII
18,19 Basics of Liquid state theory
20,22 Principles of chain systems
Modelling of peptides
23
Structural changes in proteins
24
Do
25
Protein conformational
transitions
26,28 How protein adopts unique structure
29,31 How structure is determined
32,33
34,36
37,38
39
Principles of techniques
Do
Do
Do
Protein folding
XIII
X-ray crystallography
XIV
Light scattering
Magnetic resonance
Dielectric spectroscopy
Measurement of size and shape
XV
Ref. Book
XVI
Ref. Book
5. Evaluation Scheme:
Component
Test I
Quiz
Test II
Class room tests
Compre. Exam.
Duration
50 Min.
50 Min.
50 Min.
3 hrs.
Weightage%
20%
15%
20%
15%
20%
(Descriptive)
10% (Quiz type)
Date & Time
Venue
2222
2222
2222
Remarks
CB
CB
CB
CB
OB
CB
6. Chamber Consultation Hours: To be announced.
7. Notices: Notices, if any, concerning the course will be displayed on the Notice Board of
Biological Sciences notice board.
Instructor In Charge
BIO C331
2