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BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE, PILANI INSTRUCTION DIVISION Course Handout (Part II) In addition to part-I (General Handout for all courses appended to the timetable) this portion gives further specific details regarding the course. Course No. Course Title : BIO C331 : Biophysics 1. SCOPES AND OBJECTIVE: The objective of the course is to introduce the students to the concepts of physical principles in the biological and biomimetic molecular systems. Properties and conformations of biomolecules like amino acids, proteins, nucleotides, nucleic acids as well as biomimetic systems like monolayers and bilayers are to be discussed. Related physical phenomena in these systems like structural transitions, protein folding, membrane equilibria are to be discussed. Emphasis will also be given to understand the principles of major experimental techniques applied to understand these physical problems. 2. Text Book: " Biophysical Chemistryā€¯, EDD Lecture note, Nilashis Nandi, Published by EDD, BITS, Pilani. 3. Reference Book : " Biophysical Chemistry, Part I, Part II and Part III", Charles R Cantor and Paul R. Schimmel, W.H. Freeman and Co., New York. 4. Course Plan Lec. Learning Objectives No. Understanding: Topics to be covered Ref. to Chap/Sec. T.B Properties of amino acids I Primary structure of proteins I Intermolecular interactions II 6,7 Chemical properties of basic units of life Lower level of structure of unit of life Basic interactions which drives structures Special interactions in biosystems Hydrogen bonding and hydrophobic Interaction III, IV 8 Higher level structure Tertiary Quaternary structure of V proteins 9,10 Basic units of DNA, RNA Nucleic acid Properties of nucleotides 1,2 3 4,5 1 VI 11 Structure of nucleic acids 12,13 Biomimetic systems 14,15 Role of lipids Lipids, monolayers and bilayers VII Lipids in membranes and Protein lipid interaction 16 Function of membranes Membrane equilibria VIII 17 Structure and Function Chirality and recognition IX Liquid state theory X Conformation dependent properties Polypeptides XI Helix coil transitions XII 18,19 Basics of Liquid state theory 20,22 Principles of chain systems Modelling of peptides 23 Structural changes in proteins 24 Do 25 Protein conformational transitions 26,28 How protein adopts unique structure 29,31 How structure is determined 32,33 34,36 37,38 39 Principles of techniques Do Do Do Protein folding XIII X-ray crystallography XIV Light scattering Magnetic resonance Dielectric spectroscopy Measurement of size and shape XV Ref. Book XVI Ref. Book 5. Evaluation Scheme: Component Test I Quiz Test II Class room tests Compre. Exam. Duration 50 Min. 50 Min. 50 Min. 3 hrs. Weightage% 20% 15% 20% 15% 20% (Descriptive) 10% (Quiz type) Date & Time Venue 2222 2222 2222 Remarks CB CB CB CB OB CB 6. Chamber Consultation Hours: To be announced. 7. Notices: Notices, if any, concerning the course will be displayed on the Notice Board of Biological Sciences notice board. Instructor In Charge BIO C331 2