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Characteristics of Normal Human Blood Characteristics of Normal Red Blood Cells (RBC’s) Disc shaped They stain red Contain no nucleus as mature cells We have about 5 million rbc’s/mm3 (a drop of blood) and live to 125 days. Normal Human RBC’s(Electron microscope-color) Characteristics of Normal White Blood Cells (WBC’s) Contain a single nucleus Twice as large as an RBC They stain blue or purple Blood contains 10,000 3 wbc/mm and live for 9 days. White Blood Cell Characteristics of Normal Platelets Contain one to many nuclei They occur in ‘clumps’ Stain deep blue/purple Blood contains 140,000 to 400,000 platelets/mm3 and they live for 10 days  Platelets What’s Wrong With this Blood? Blood Slide 1: Normal human blood Blood Slide 2-sickle cell anemia FACTS Inherited  RBCs rupture easily  Results in extreme fatigue  Provides protection against malaria  Blood Slide 3: Anemia Normal FACTS Usually caused by diet low in iron  Less hemoglobin means less oxygen carried  Results in fatigue  Blood Slide 4: African Sleeping Sickness (Trypanosoma) FACTS Caused by protozoan.  Transmitted through the bite of a tsetse fly (Africa)  Protozoan rapidly divides in the body  Causes fever, headache, itchiness, joint pain, and death if not treated (about 10,000 per year affected)  Blood Slide 5: Malaria (Plasmodium) protozoans rbc Trypanosomiasis FACTS Caused by a protozoan (Plasmodium)  Transmitted through a mosquito bite  Parasite destroys cells and infects liver  Produces strong flu-like symptoms and extreme chills  Can be deadly (2010, 216 million malaria cases in world and about 655 000 malaria deaths)  Tropical disease   Jeremy Piven Anderson Cooper  George Clooney  Blood slide 6: bacterial infection  WBC (orange) engulfing bacteria RODS FACTS Bacteria enter blood usually through cut or wound  Staphylococcus common infection  Bacteria produce toxins which damage cells  Can be fatal if not treated with antibiotics  Blood Slide 7: Leukemia RBC Large immature WBC FACTS Cancer  Caused by uncontrolled production of WBCs  WBCs build up in tissues and block normal function  Blood Slide 8: Megaloblastic Anemia Very large RBC, malformed FACTS Usually caused by diet low in vitamin B12 and folic acid (leafy green vegetables)  Fewer red blood cells means less oxygen carried  Causes fatigue