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Annexure ‘CD – 01’ FORMAT FOR COURSE CURRICULUM Course Title: CHEMISTRY OF NATURAL PRODUCTS L T P/S SW/F W 2 1 2 - Credit Units: 04 Course Level: UG TOTAL CREDIT UNITS 4 Course Code: Course Objectives: To familiarize the students with the various metabolic pathways, extraction and chemistry of different classes of various chemical constituents obtained from plants. Pre-requisites: Knowledge of Chemistry of Plant related Constituents. Student Learning Outcomes: 1) Knowledge of basics of Natural Products. 2) Understand the concepts of isolation and extraction of alkaloids,steroids, triterpinoids, carotenoids, pigments and marine plants 3) Illustrate the Herbal Cosmetics, Allergens & Recent developments in natural products. 4) At the end of the course the student would have a sound knowledge about the basics of the various metabolic pathways, extraction and chemistry of different classes of various chemical constituents obtained from plants. Course Contents/Syllabus: Module I: Introduction to Biogenetics Weightage (%) 20% Descriptors/Topics Biogenetics Investigations and basic metabolic pathways, (alkaloids, terpenes, steroids) Brief Introduction to biogenesis of secondary metabolites of Pharmaceutical importance. Module II: Extraction, Isolation & Chemistry 20% Descriptors/Topics : i) Glycosides - Digitoxin, Hecogenin, Diosgenin ii) Lignans iii) Quassinoids iv) Flavonoids (Quercetin, Rutin) Module III : Alkaloids 20% Descriptors/Topics : Atropine & related compounds, quinine, reserpine, morphine, papaverine, ephedrine, and ergot. Module IV : Extraction, Isolation & Chemistry of Terpenoids 20% Descriptors/Topics : Camphor, Menthol, Citral, β- Carotene, α -Tocopherol, α-Pinene Module V: Herbal Cosmetics, Allergens & Recent developments in natural products Descriptors/Topics Natural Allergens and Photosensitizing agents. Herbal Cosmetics and their formulation (Shampoos, dental products, sunscreen, foot cracking creams, personal hygiene products including marketed preparations) Recent developments of natural products used as anticancer agents, antidiabetics, hepatoprotective and immunomodulators. Pedagogy for Course Delivery: Traditional Board-Marker teaching & PPT presentation Lab/ Practicals details, if applicable: 20% 1. Isolation of caffeine from Tea leaves. 2. Isolation of piperine from Black Pepper. 3. Isolation of Hesperidin from Orange Peel. 4. Isolation of Clove oil from clove. 5. Isolation of Caraway oil from caraway. 6. Isolation of cumin oil from cumin. 7. To study the TLC profile of extracted oils. 8. To performs the column chromatography of any available herb. 9. To study the paper chromatographic profile of glycone portion separated from senna. 10. To Isolate the active constituent of any available drug with the help of preparative TLC. 11. Quantitative determination of Ascorbic acid present in Amla. (Fresh/ Dry). Assessment/ Examination Scheme: Theory L/T (%) Lab/Practical/Studio (%) Total 75% 25% 100% Theory Assessment (L&T): Continuous Assessment/Internal Assessment End Term Examination Components (Drop down) A CT-I CT-II Ass/Viva/Q Weightage (%) 05 10 10 05 70 Lab/ Practical/ Studio Assessment: Continuous Assessment/Internal Assessment End Term Examination Components (Drop down A Performance Lab. Record Viva PR Viva Weightage (%) 05 15 05 05 40 30 Total 70 Text Reading: I.L. Finar “Organic chemistry” Vol. I & II ELBS, London. O.P. Agarwal, “Chemistry of Organic Natural Product” Vol. I & II Goel Pub. House, Meerut. Trease G.E. & Evan, W.C., “Pharmacognosy” Bailleire tindall East bourne, U.K. Tyler V.E. etal “Pharmacognosy” Lea & Febiger Philadelphia. Kokate, C.K. “Pharmacognosy” Nirali Prakashan, Pune. Pridham JB & Swain T. Biosynthetic pathway Higher plants, Academic Press, New Delhi References: Sim, Medicinal Plant Alkaloids & Glycosides. Brain, K.R., & Turner T.D, The Practical evaluation of phytopharmaceutical, Wright, Bristol. Kokate C.K., “Practical Pharmacognosy” Vallabh Prakashan, New Delhi. Stahl E. “Thin layer chromatography” A Laboratory Hand Book, Springer Verlag, Berlin. Harborne, J.B. Phytochemical Methods Chapman & Hall, International Ed, London Additional Materials: Research Papers from various Journals