Download Course Title: CHEMISTRY OF NATURAL PRODUCTS

Annexure ‘CD – 01’
FORMAT FOR COURSE CURRICULUM
Course Title: CHEMISTRY OF NATURAL PRODUCTS
L
T
P/S
SW/F
W
2
1
2
-
Credit Units: 04
Course Level: UG
TOTAL
CREDIT
UNITS
4
Course Code:
Course Objectives: To familiarize the students with the various metabolic pathways, extraction and chemistry of different classes of various chemical
constituents obtained from plants.
Pre-requisites: Knowledge of Chemistry of Plant related Constituents.
Student Learning Outcomes:
1) Knowledge of basics of Natural Products.
2) Understand the concepts of isolation and extraction of alkaloids,steroids, triterpinoids, carotenoids, pigments and marine plants
3) Illustrate the Herbal Cosmetics, Allergens & Recent developments in natural products.
4) At the end of the course the student would have a sound knowledge about the basics of the various metabolic pathways, extraction and chemistry of
different classes of various chemical constituents obtained from plants.
Course Contents/Syllabus:
Module I: Introduction to Biogenetics
Weightage (%)
20%
Descriptors/Topics
Biogenetics Investigations and basic metabolic pathways, (alkaloids, terpenes, steroids) Brief
Introduction to biogenesis of secondary metabolites of Pharmaceutical importance.
Module II:
Extraction, Isolation & Chemistry
20%
Descriptors/Topics :
i) Glycosides - Digitoxin, Hecogenin, Diosgenin
ii) Lignans
iii) Quassinoids
iv) Flavonoids (Quercetin, Rutin)
Module III : Alkaloids
20%
Descriptors/Topics :
Atropine & related compounds, quinine, reserpine, morphine, papaverine, ephedrine, and ergot.
Module IV : Extraction, Isolation & Chemistry of Terpenoids
20%
Descriptors/Topics :
Camphor, Menthol, Citral, β- Carotene, α -Tocopherol, α-Pinene
Module V: Herbal Cosmetics, Allergens & Recent developments in natural products
Descriptors/Topics
Natural Allergens and Photosensitizing agents.
Herbal Cosmetics and their formulation (Shampoos, dental products, sunscreen, foot cracking creams, personal hygiene
products including marketed preparations)
Recent developments of natural products used as anticancer agents, antidiabetics, hepatoprotective and
immunomodulators.
Pedagogy for Course Delivery: Traditional Board-Marker teaching & PPT presentation
Lab/ Practicals details, if applicable:
20%
1. Isolation of caffeine from Tea leaves.
2. Isolation of piperine from Black Pepper.
3. Isolation of Hesperidin from Orange Peel.
4. Isolation of Clove oil from clove.
5. Isolation of Caraway oil from caraway.
6. Isolation of cumin oil from cumin.
7. To study the TLC profile of extracted oils.
8. To performs the column chromatography of any available herb.
9. To study the paper chromatographic profile of glycone portion separated from senna.
10. To Isolate the active constituent of any available drug with the help of preparative TLC.
11. Quantitative determination of Ascorbic acid present in Amla. (Fresh/ Dry).
Assessment/ Examination Scheme:
Theory L/T (%)
Lab/Practical/Studio (%)
Total
75%
25%
100%
Theory Assessment (L&T):
Continuous Assessment/Internal Assessment
End Term Examination
Components (Drop down)
A
CT-I
CT-II
Ass/Viva/Q
Weightage (%)
05
10
10
05
70
Lab/ Practical/ Studio Assessment:
Continuous Assessment/Internal Assessment
End Term Examination
Components (Drop down
A
Performance
Lab. Record
Viva
PR
Viva
Weightage (%)
05
15
05
05
40
30
Total
70
Text Reading:
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




I.L. Finar “Organic chemistry” Vol. I & II ELBS, London.
O.P. Agarwal, “Chemistry of Organic Natural Product” Vol. I & II Goel Pub. House, Meerut.
Trease G.E. & Evan, W.C., “Pharmacognosy” Bailleire tindall East bourne, U.K.
Tyler V.E. etal “Pharmacognosy” Lea & Febiger Philadelphia.
Kokate, C.K. “Pharmacognosy” Nirali Prakashan, Pune.
Pridham JB & Swain T. Biosynthetic pathway Higher plants, Academic Press, New Delhi
References:
 Sim, Medicinal Plant Alkaloids & Glycosides.
 Brain, K.R., & Turner T.D, The Practical evaluation of phytopharmaceutical, Wright, Bristol.
 Kokate C.K., “Practical Pharmacognosy” Vallabh Prakashan, New Delhi.
 Stahl E. “Thin layer chromatography” A Laboratory Hand Book, Springer Verlag, Berlin.
Harborne, J.B. Phytochemical Methods Chapman & Hall, International Ed, London
Additional Materials: Research Papers from various Journals