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OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015)
BIOGRAPHICAL SKETCH
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NAME: LaBeaud, Angelle Desiree
eRA COMMONS USER NAME (credential, e.g., agency login): DLABEAUD
POSITION TITLE: Associate Professor, Pediatric Infectious Diseases
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing,
include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)
INSTITUTION AND LOCATION
University of California, San Diego
La Jolla, CA
Medical College of Wisconsin
Milwaukee, WI
Case Western Reserve University
Cleveland, Ohio
DEGREE
(if
applicable)
Completion
Date
MM/YYYY
FIELD OF STUDY
B.S.
06/96
General Biology
M.D.
05/00
Medicine
M.S.
05/09
Clinical Investigation
A. Personal Statement
I have conducted human field epidemiologic research on arboviruses, including chikungunya virus (CHIKV)
and dengue virus (DENV), for more than a decade and have developed the experience, expertise, and
collaborative networks needed to manage and coordinate the complex field projects. I have a broad
background in pediatric infectious disease, with specific training in key research areas such as child health,
tropical medicine, epidemiology, and advanced immunology. I have successfully supervised international
projects, collaborated with foreign researchers, and organized the resulting collaborative publications in peerreviewed journals. I am PI on a NIAID R01 award to determine the transmission dynamics of and human
disease attributable to DENV and CHIKV in Kenya. I am also PI on an NIAID R24 award to develop and field
test a system for remote collection and processing of T cells from pediatric patients previously exposed to
DENV and/or CHIKV. I am co-PI on a Fogarty R21 to enhance the child neurodevelopmental evaluation
capacity in Grenada and estimate the effect of peripartum chikungunya virus infection on child
neurodevelopment. I am also PI on a Stanford Child Health Research Institute new ideas award to study the
impact of Zika virus on child health in Grenada. I was recently awarded (with Co-I Maecker) an ITI award to
study the immune mechanisms underlying the harmful effects of antenatal parasitic infections on vaccine
response in offspring. I was awarded (with Co-PI Mordecai) a Stanford Center for Innovation in Global Health
seed grant and an Environmental Venture Project to create predictive models for dengue transmission in
Kenya and Ecuador. Finally, I am PI of a Bechtel Faculty Scholar Award, from the Stanford Child Health
Research Institute to study integrated vector management as a strategy for reduced arboviral disease risk in
Kenya.
B. Positions and Honors
Positions
2000 – 2003
2003 – 2006
2006 – 2007
2007 – 2009
Pediatric Resident, International Health Track; Rainbow Babies and Children’s Hospital;
Cleveland, OH
Fellow, Division of Pediatric Infectious Diseases; Rainbow Babies and Children’s Hospital;
Cleveland, OH
Instructor, Division of Pediatric Infectious Diseases; Rainbow Babies and Children’s
Hospital; Cleveland, OH
Assistant Professor, Division of Pediatric Infectious Diseases;
2009 – 2014
2009 – present
2009 – 2014
2013 – 2014
2013 – 2014
2014 – present
Rainbow Babies and Children’s Hospital; Cleveland, OH
Assistant Scientist, Children’s Hospital of Oakland Research Institute (CHORI); Oakland, CA
Adjunct Assistant Professor, Center for Global Health and Diseases;
Case Western Reserve University (CWRU); Cleveland, OH
Associate Physician, Division of Infectious Disease Medical Group at the Children’s Hospital
& Research Center Oakland (CHRCO); Oakland, CA
Fellowship Director, Division of Infectious Disease Medical Group at CHRCO; Oakland, CA
Associate Scientist, CHORI; Oakland, CA
Associate Professor, Pediatric Infectious Diseases, Stanford University, Palo Alto CA
Honors
1992 – 1996
1996
1998
1999 – present
2000
2000
2001 – 2003
2002
2004 – 2006
2006
2006 – 2008
2006 – 2008
2006 – 2009
2007 – 2008
2008
2008
2008
2008 – 2009
2008 – present
2008 – present
2009 – present
2009 – present
2009 – 2010
2010
2010 – present
2010 – 2012
2010, 2011
2011, 2012
2011 – 2012
2012
2012, 2013
2012, 2013
2012 – present
2013 – present
2013
2013
2013– present
2013– present
2013
Provost’s Honors, UCSD
Undergraduate Graduation with Honors, Cum Laude, UCSD
Medical Student Research Fellowship/ NIH Summer Training Grant
Alpha Omega Alpha Honor Society
Merck Award in recognition of outstanding academic achievement
American Medical Woman’s Association Award
AAP Residency Program Representative
Excellence In Patient Care Award
NIH Clinical Research Loan Repayment Award
Science Day Fellow’s Research Award
Director, International Pediatric Chat, Rainbow Center for Global Child Health
Associate Editor, PLoS Neglected Tropical Diseases
Multidisciplinary Clinical Research Training Program Scholar
NIH Clinical Research Loan Repayment Award
Women Faculty of the School of Medicine at CWRU Junior Faculty Award
CWRU Research ShowCASE Graduate Student Competition First Prize Award
Robert E. Shope International Fellowship in Infectious Diseases Award
NIH Clinical Research Loan Repayment Award
Deputy Editor, PLoS Neglected Tropical Diseases
ASTMH CME/Courses Committee Member
Member, ASTMH Travel Award Selection Committee
Member, American Academy of Pediatrics International Research Award Selection
Committee
NIH Clinical Research Loan Repayment Award
New Investigator in Global Health Scholarship awardee/presenter at the Global Health
Council’s Annual International Conference on Global Health
Country Projects Director, Children’s Global Health Initiative, CHORI
Co-Fellowship Director, Division of Pediatric Infectious Diseases, CHRCO
Journal Editor Round Table Participant, National Science Advisory Board for Biosecurity
(NSABB)
Deutsche Forschungsgemeinschaft (DFG) German Research Foundation Grant Reviewer,
Joint German-African Cooperation Projects in Infectiology
NIH Clinical Research Loan Repayment Award
Councilor, American Society of Tropical Medicine & Hygeine
NIH Peer Grant Reviewer, Loan Repayment Program Special Emphasis Study Section
Wellcome Trust Sir Henry Wellcome Postdoctoral Fellowship Review Panel
Blue Ribbon Committee Member, ASTMH
Fellowship Director, Division of Pediatric Infectious Diseases, CHRCO
WHO Informal Consultation on Dual Use Research of Concern, Invited PLOS
representative, Geneva, Switzerland
ZAI- LR-M-J1, U19 peer reviewer, NIAID Centers of Excellence in Translational Research
(CETR)
Chair, Blue Ribbon ASTMH Committee: CTropMedExam Working Group
Member, Dual Use Research of Concern Committee, PLoS Journals
NIH Study Section ZGM1 BBCB-5 (MI)1: Models of Infectious Disease Agent Study
2014
2015
2015
2015 – 2020
2015– present
2016– present
2016
2016
2016– present
NIH Study Section ZAI-AWA-M-S1: NIAID International Collaborations in Infectious
Diseases Research (ICIDR) study section
Ad hoc member, NIH Study Section CRFS: Clinical Research and Field Studies
NIH Study Section ZAI-BLG-M-S4, R24 peer reviewer
Bechtel Faculty Scholar Award, Stanford Child Health Research Institute
Councilor, American Committee on Arthropod-Borne Viruses
Chair, Ben Kean Travel Fellowship Award Committee, ASTMH
NIH Study Section ZRG1 PSE-U 02 M IRAP and SSPA Member SEP
NIH Study Section PAR 14-080 International Research in Infectious Diseases
Chair-elect, American Committee on Arthropod-Borne Viruses
C. Contribution to Science
The major research area in which I’ve contributed is arboviral epidemiology. My early publications directly
addressed the fact that transmission of Rift Valley fever virus (RVFV) is often overlooked in endemic
communities. We demonstrated a great burden of exposure both during and in between recognized outbreaks
in both human (1-3) and animal (4) populations. This body of work changed the areas thought to be at risk for
RVFV transmission and provided evidence for unrecognized transmission in both adults and children. I served
as the primary investigator or co-investigator in these studies.
1. LaBeaud AD, Ochiai Y, Peters CJ, Muchiri EM, King CH. Spectrum of Rift Valley fever virus
transmission in Kenya: insights from three distinct regions. Am J Trop Med Hyg. 2007 May;76(5):795800. PMCID: PMC2367216.
2. LaBeaud AD, Muchiri EM, Ndzovu M, Mwanje MT, Muiruri S, Peters CJ, King CH. Interepidemic Rift
Valley fever virus seropositivity, northeastern Kenya. Emerg Infect Dis. 2008 Aug;14(8):1240-6. PMCID:
PMC2600406.
3. LaBeaud AD, Muiruri S, Sutherland LJ, Dahir S, Gildengorin G, Morrill J, Muchiri EM, Peters CJ, King
CH. Postepidemic Analysis of Rift Valley Fever Virus Transmission in Northeastern Kenya: A Village
Cohort Study. PLoS Neglected Tropical Diseases Journal, 2011 Aug;5(8):e1265. Epub 2011 Aug 16.
PMCID: PMC3156691.
4. LaBeaud AD, Cross P, Getz W, Glinka A, King CH. Rift Valley fever virus infection in African buffalo
(Syncerus caffer) herds in rural South Africa--Evidence of inter-epizootic transmission. Am J Trop Med
Hyg. 2011 Apr;84(4):641-6. PMCID: PMC3062463.
5. Gray GC, Anderson BD, LaBeaud AD, Heraud JM, Fèvre EM, Andriamandimby SF, Cook EA, Dahir S,
de Glanville WA, Heil GL, Khan SU, Muiruri S, Olive MM, Thomas LF, Merrill HR, Merrill ML, Richt JA.
Seroepidemiological Study of Interepidemic Rift Valley Fever Virus Infection Among Persons with
Intense Ruminant Exposure in Madagascar and Kenya. Am J Trop Med Hyg. 2015 Oct 12.
The spectrum of human RVF disease is broad and the factors that determine severe vs. mild disease are not
well understood. It is likely that immune (5), demographic (6) and genetic (7) factors are all important to
determine clinical manifestations of disease. I served as the primary investigator or co-investigator in these
studies.
6. Newman-Gerhardt S, Muiruri S, Muchiri EM, Peters CJ, Morrill, Lucas AH, King CH, Kazura J,
LaBeaud AD. Potential for Autoimmune Pathogenesis of Rift Valley Fever Virus Retinitis, Accepted
for publication, American Journal of Tropical Medicine & Hygiene, 2013 Sep;89(3):495-7
7. LaBeaud AD, Pfeil S, Muiruri S, Dahir S, Sutherland LJ, Traylor Z, Gildengorin G, Muchiri EM, Morrill J,
Peters CJ, Hise AG, Kazura JW, King CH. Factors Associated with Severe Human Rift Valley Fever in
Sangailu, Garissa County, Kenya. PLoS Negl Trop Dis 9(3): e0003548.
doi:10.1371/journal.pntd.0003548.
8. Hise AG, Traylor Z, Hall NB, Sutherland LJ, Dahir S, Ermler ME, Muiruri S, Muchiri EM, Kazura JW,
LaBeaud AD, King CH, Stein CM. Association of Symptoms and Severity of Rift Valley Fever with
Genetic Polymorphisms in Human Innate Immune Pathways. PLoS Negl Trop Dis 9(3): e0003584.
doi:10.1371/journal.pntd.0003584
In addition to work on RVFV above, I expanded my work to include other arboviruses of human importance.
Again we have demonstrated a great burden of exposure to many pathogens (8) and a large proportion of
infected vectors in our study sites (9). More recently, we have uncovered intense transmission of viruses
previously unrecognized (11). This work continues to uncover unrecognized transmission of these pathogens
and provide evidence for resultant human infection and disease. The disease burden is due not only to the
acute febrile illness, but also to the long-term health consequences that result from arboviral infection (12). I
served as the primary investigator or co-investigator in these studies.
9. Sutherland LJ, Cash AA, Sang RC, Huang YS, Malhotra I, King CL, Moormann AM, Weaver SC, King
CH, and LaBeaud AD. Serological Evidence of Arboviral Infections among Humans in Kenya.
American Journal of Tropical Medicine & Hygiene, 2011 Jul;85(1):158-61. PMCID: PMC3122361.
10. LaBeaud AD, Sutherland LJ, Muiruri S, Gray L, Zimmerman PA, Hise AG, King CH. Arbovirus
Prevalence in mosquitoes, Kenya. Emerging Infectious Diseases Journal, 2011 Feb: 17(2):233-41.
PMCID: PMC3204744.
11. LaBeaud AD, Banda T, Brichard J, Borland E, Mungai PL, Mutuku FM, Gildengorin V, Pfeil S, Teng
CY, Long K, Heise M, Muchiri EM, Powers AM, Kitron U, King CH. High rates of o'nyong nyong and
chikungunya virus transmission in coastal Kenya. PLoS Negl Trop Dis, 2015; 9(2): e0003436.
doi:10.1371/journal.pntd.0003436
12. LaBeaud AD, Bashir F, King CH. Measuring the Burden of Arboviral Diseases: The Spectrum of
Morbidity and Mortality from Four Prevalent Infections. Population Health Metrics, 2011 Jan 10;9(1):1.
PMCID: PMC3024945.
As a pediatrician, I have always been interested in the clinical manifestations of arboviruses and differences
between child and adult presentations (13,14). Children are often excluded from outbreak studies, so little is
known about the specific risk factors of (12), health consequences to (13), or optimal prevention strategies for
(14) children. I served as the primary investigator or co-investigator in these studies.
13. LaBeaud AD, Kile JR, Kippes C, King CH, Mandalakas AM. Exposure to West Nile virus during the
2002 epidemic in Cuyahoga County, Ohio: a comparison of pediatric and adult behaviors. Public Health
Rep. 2007 May-Jun;122(3):356-61. PMCID: PMC1847498.
14. LaBeaud AD, Lisgaris MV, King CH, Mandalakas AM. Pediatric West Nile virus infection: neurologic
disease presentations during the 2002 epidemic in Cuyahoga County, Ohio. Pediatr Infect Dis J. 2006
Aug;25(8):751-3.
15. LaBeaud AD, Glinka A, Kippes C, King CH. School-based health promotion for mosquito-borne
disease prevention in children. J Pediatr. 2009 Oct;155(4):590-2. PMCID: PMC3104726.
Unrelated to arboviruses, but intensely important for children’s health, we have performed studies to evaluate
the effects of parasitism on childhood vaccine response in our communities. Although parasites are known to
disrupt immunity, our studies suggest a novel idea that priming of the fetal immune system in utero by
parasites effects later immune function in childhood (15, 16). This research has important policy implications
for mass drug administration programs for parasite control, mass vaccination campaigns in parasite-endemic
areas, and supplies crucial data regarding the effects of parasites on child health and development (17). I
served as the primary investigator or co-investigator in these studies.
16. Labeaud AD, Malhotra I, King MJ, King CL, King CH. Do antenatal parasite infections devalue
childhood vaccination? PLoS Negl Trop Dis. 2009 May 26;3(5):e442. PMCID: PMC2682196.
17. Malhotra I, McKibben M, Mungai P, McKibben E, Wang X, Sutherland LJ, Muchiri E, King CH, King CL,
LaBeaud AD. Effect of Antenatal Parasitic Infections on Anti-vaccine IgG levels in Children: A
Prospective Birth Cohort Study in Kenya. PLoS Negl Trop Dis 2015; 9(1): e0003466.
doi:10.1371/journal.pntd.0003466
18. LaBeaud AD, Singer MN, McKibben M, Mungai P, Muchiri EM, McKibben E, Gildengorin G, Sutherland
LJ, King CH, King CL, Malhotra I. Parasitism in Children Aged Three Years and Under: Relationship
Between Infection and Growth in Rural Coastal Kenya. PLoS Negl Trop Dis 9(5): e0003721.
doi:10.1371/journal.pntd.0003721
A complete list of my published work is available at:
http://www.ncbi.nlm.nih.gov/sites/myncbi/1PyVBywa_Wkt/bibliography/40449230/public/?sort=date&direction=ascending
D. Research Support
Ongoing Research Support
1/2017-12/2017
Stanford Child Health Research Institute: The Spectrum of Zika Virus Disease in Grenada;
Principal Investigator: AD LaBeaud; Goal: To determine factors associated with mother to
child transmission of ZIKV and the long-term consequences of congenital ZIKV disease.
Role: Awardee/PI
9/2016-8/2018
NIH, R21TW010536; Neurodevelopment and Vector-borne Diseases: Building Research
Capacity in the Tropics; Principal Investigators: AD LaBeaud and R Waechter; Goal: To
estimate the effect of peripartum chikungunya virus infection on child neurodevelopment.
Role: Co-PI
9/2016-8/2018
Stanford Institute for Immunity, Transplantation and Infection Seed Interdisciplinary
Research Award: Characterizing the Effects of Antenatal Parasitic Infection on Fetal Immune
System Development; Principal Investigator: AD LaBeaud; Goal: To identify immune
signatures of parasite fetal priming using both functional and genomic T cell investigations,
and analysis of B cell repertoires. Role: Awardee/Co-PI
7/2016-6/2018
Stanford Woods Institute Environmental Venture Project grant; Predicting Dengue
Transmission in a Changing Climate to Improve Mosquito Control; Principal Investigators:
AD LaBeaud and E Mordecai; Goal: To use mathematical models, field data, and remote
sensing to predict dengue transmission, and to apply the predictive models to improve
vector control in Kenya and Ecuador. Role: Co-PI
1/2016-12/2016
Center for Innovation in Global Health Seed Grant, Stanford University; Predicting Dengue
Transmission in a Changing Climate; Principal Investigators: AD LaBeaud and E Mordecai;
Goal: To develop and validate predictive models of dengue transmission based on climate
data. Role: Awardee/Co-PI
9/2015-8/2020
Bechtel Faculty Scholar Award, Stanford Child Health Research Institute; Integrated Vector
Management as a Strategy for Reduced Disease Risk in a Newly Discovered Region of
Dengue Fever in Africa; Principal Investigator: AD LaBeaud; Goal: To measure the impact of
school- and household-based educational interventions on mosquito larval control in Kenya.
Role: Awardee/PI
7/2015-6/2020
NIH, U24AI118648; Miniaturized Automated Whole Blood Cellular Analysis System;
Principal Investigators: AD LaBeaud and H Maecker; Goal: To create an easy to use
automated system for stimulation and storage of small-volume whole blood samples for
functional assays, and to validate the system’s performance in a cohort of pediatric subjects
seen at point-of-care clinics in Kenya. Role: Co-PI
7/2013-6/2018
NIH, R01AI102918; The Burden of Chikungunya and Dengue Transmission, Infection and
Disease in Kenya; Principal Investigator: AD LaBeaud; Goal: To estimate the burden of
infection and disease from dengue and chikungunya viruses in Kenya. Role: PI
11/2012-10/2016 OPP1066865 Bill and Melinda Gates Foundation Healthy Growth Award; Enhancing Infant
Immunity: Effect of Early Maternal Treatment for Parasitic Infections; PI: Charles King, MD;
Goal: To examine the impact of maternal infections during pregnancy on the tolerization of
immune response in infants, and its related effects on vaccine efficacy (coastal Kenya).
Role: Co-investigator
Completed Research Support (last 3 years only)
8/2015-7/2016
American Society of Tropical Medicine and Hygiene, Robert E. Shope International
Fellowship in Infectious Diseases; Characterization of Immune Factors of Severe and
Chronic Chikungunya Disease in Grenada, West Indies; Role: Mentor
3/2012-2/2014
NIH PNWRCE New Research Project Award, “The Burden of Chikungunya and Dengue
Infection in Kenya;” PI: Desiree LaBeaud, MD; Goal: To quantify the prevalence of
chikungunya and dengue virus exposure in Kenya and then detect and predict spatial and
temporal patterns of transmission; Role: PI
4/2009-2/2014
NIH, U54AI057160; Midwest Regional Center of Excellence Program Project Award: Innate
Immunity of Rift Valley Fever Virus; PI: Herbert Virgin; Program Leader: James Kazura, MD;
Goal: To evaluate the contribution of innate immunology and genetics to the clinical
spectrum of human RVF; Role: Co-I
4/2010-4/2013
NIH, 1R03HD058587; The effects of polyparasitism on vaccine response; PI: Desiree
LaBeaud, MD and Indu Malhotra, PhD; Goal: To test whether antenatal parasitic infections
and treatments impact postnatal response to H. influenzae type B, diphtheria, hepatitis B
virus, and polio vaccines; Role: PI
1/2011-6/2013
Department of Homeland Security: Center of Excellence for Emerging Zoonotic Animal
Diseases, "Risk Factors for Rift Valley Fever Virus Infections among Herders in Kenya,
Saudi Arabia, South Africa, and Madagascar"; PI: Gregory Gray, MD; Goal: To evaluate the
risk factors for RVFV infection in herders; Role: Kenya Site PI