* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download biographical sketch - CAP Network
Survey
Document related concepts
Schistosomiasis wikipedia , lookup
Sexually transmitted infection wikipedia , lookup
Middle East respiratory syndrome wikipedia , lookup
West Nile fever wikipedia , lookup
Hospital-acquired infection wikipedia , lookup
African trypanosomiasis wikipedia , lookup
Oesophagostomum wikipedia , lookup
Henipavirus wikipedia , lookup
Hepatitis B wikipedia , lookup
Neglected tropical diseases wikipedia , lookup
Marburg virus disease wikipedia , lookup
Transcript
OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FIVE PAGES. NAME: LaBeaud, Angelle Desiree eRA COMMONS USER NAME (credential, e.g., agency login): DLABEAUD POSITION TITLE: Associate Professor, Pediatric Infectious Diseases EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.) INSTITUTION AND LOCATION University of California, San Diego La Jolla, CA Medical College of Wisconsin Milwaukee, WI Case Western Reserve University Cleveland, Ohio DEGREE (if applicable) Completion Date MM/YYYY FIELD OF STUDY B.S. 06/96 General Biology M.D. 05/00 Medicine M.S. 05/09 Clinical Investigation A. Personal Statement I have conducted human field epidemiologic research on arboviruses, including chikungunya virus (CHIKV) and dengue virus (DENV), for more than a decade and have developed the experience, expertise, and collaborative networks needed to manage and coordinate the complex field projects. I have a broad background in pediatric infectious disease, with specific training in key research areas such as child health, tropical medicine, epidemiology, and advanced immunology. I have successfully supervised international projects, collaborated with foreign researchers, and organized the resulting collaborative publications in peerreviewed journals. I am PI on a NIAID R01 award to determine the transmission dynamics of and human disease attributable to DENV and CHIKV in Kenya. I am also PI on an NIAID R24 award to develop and field test a system for remote collection and processing of T cells from pediatric patients previously exposed to DENV and/or CHIKV. I am co-PI on a Fogarty R21 to enhance the child neurodevelopmental evaluation capacity in Grenada and estimate the effect of peripartum chikungunya virus infection on child neurodevelopment. I am also PI on a Stanford Child Health Research Institute new ideas award to study the impact of Zika virus on child health in Grenada. I was recently awarded (with Co-I Maecker) an ITI award to study the immune mechanisms underlying the harmful effects of antenatal parasitic infections on vaccine response in offspring. I was awarded (with Co-PI Mordecai) a Stanford Center for Innovation in Global Health seed grant and an Environmental Venture Project to create predictive models for dengue transmission in Kenya and Ecuador. Finally, I am PI of a Bechtel Faculty Scholar Award, from the Stanford Child Health Research Institute to study integrated vector management as a strategy for reduced arboviral disease risk in Kenya. B. Positions and Honors Positions 2000 – 2003 2003 – 2006 2006 – 2007 2007 – 2009 Pediatric Resident, International Health Track; Rainbow Babies and Children’s Hospital; Cleveland, OH Fellow, Division of Pediatric Infectious Diseases; Rainbow Babies and Children’s Hospital; Cleveland, OH Instructor, Division of Pediatric Infectious Diseases; Rainbow Babies and Children’s Hospital; Cleveland, OH Assistant Professor, Division of Pediatric Infectious Diseases; 2009 – 2014 2009 – present 2009 – 2014 2013 – 2014 2013 – 2014 2014 – present Rainbow Babies and Children’s Hospital; Cleveland, OH Assistant Scientist, Children’s Hospital of Oakland Research Institute (CHORI); Oakland, CA Adjunct Assistant Professor, Center for Global Health and Diseases; Case Western Reserve University (CWRU); Cleveland, OH Associate Physician, Division of Infectious Disease Medical Group at the Children’s Hospital & Research Center Oakland (CHRCO); Oakland, CA Fellowship Director, Division of Infectious Disease Medical Group at CHRCO; Oakland, CA Associate Scientist, CHORI; Oakland, CA Associate Professor, Pediatric Infectious Diseases, Stanford University, Palo Alto CA Honors 1992 – 1996 1996 1998 1999 – present 2000 2000 2001 – 2003 2002 2004 – 2006 2006 2006 – 2008 2006 – 2008 2006 – 2009 2007 – 2008 2008 2008 2008 2008 – 2009 2008 – present 2008 – present 2009 – present 2009 – present 2009 – 2010 2010 2010 – present 2010 – 2012 2010, 2011 2011, 2012 2011 – 2012 2012 2012, 2013 2012, 2013 2012 – present 2013 – present 2013 2013 2013– present 2013– present 2013 Provost’s Honors, UCSD Undergraduate Graduation with Honors, Cum Laude, UCSD Medical Student Research Fellowship/ NIH Summer Training Grant Alpha Omega Alpha Honor Society Merck Award in recognition of outstanding academic achievement American Medical Woman’s Association Award AAP Residency Program Representative Excellence In Patient Care Award NIH Clinical Research Loan Repayment Award Science Day Fellow’s Research Award Director, International Pediatric Chat, Rainbow Center for Global Child Health Associate Editor, PLoS Neglected Tropical Diseases Multidisciplinary Clinical Research Training Program Scholar NIH Clinical Research Loan Repayment Award Women Faculty of the School of Medicine at CWRU Junior Faculty Award CWRU Research ShowCASE Graduate Student Competition First Prize Award Robert E. Shope International Fellowship in Infectious Diseases Award NIH Clinical Research Loan Repayment Award Deputy Editor, PLoS Neglected Tropical Diseases ASTMH CME/Courses Committee Member Member, ASTMH Travel Award Selection Committee Member, American Academy of Pediatrics International Research Award Selection Committee NIH Clinical Research Loan Repayment Award New Investigator in Global Health Scholarship awardee/presenter at the Global Health Council’s Annual International Conference on Global Health Country Projects Director, Children’s Global Health Initiative, CHORI Co-Fellowship Director, Division of Pediatric Infectious Diseases, CHRCO Journal Editor Round Table Participant, National Science Advisory Board for Biosecurity (NSABB) Deutsche Forschungsgemeinschaft (DFG) German Research Foundation Grant Reviewer, Joint German-African Cooperation Projects in Infectiology NIH Clinical Research Loan Repayment Award Councilor, American Society of Tropical Medicine & Hygeine NIH Peer Grant Reviewer, Loan Repayment Program Special Emphasis Study Section Wellcome Trust Sir Henry Wellcome Postdoctoral Fellowship Review Panel Blue Ribbon Committee Member, ASTMH Fellowship Director, Division of Pediatric Infectious Diseases, CHRCO WHO Informal Consultation on Dual Use Research of Concern, Invited PLOS representative, Geneva, Switzerland ZAI- LR-M-J1, U19 peer reviewer, NIAID Centers of Excellence in Translational Research (CETR) Chair, Blue Ribbon ASTMH Committee: CTropMedExam Working Group Member, Dual Use Research of Concern Committee, PLoS Journals NIH Study Section ZGM1 BBCB-5 (MI)1: Models of Infectious Disease Agent Study 2014 2015 2015 2015 – 2020 2015– present 2016– present 2016 2016 2016– present NIH Study Section ZAI-AWA-M-S1: NIAID International Collaborations in Infectious Diseases Research (ICIDR) study section Ad hoc member, NIH Study Section CRFS: Clinical Research and Field Studies NIH Study Section ZAI-BLG-M-S4, R24 peer reviewer Bechtel Faculty Scholar Award, Stanford Child Health Research Institute Councilor, American Committee on Arthropod-Borne Viruses Chair, Ben Kean Travel Fellowship Award Committee, ASTMH NIH Study Section ZRG1 PSE-U 02 M IRAP and SSPA Member SEP NIH Study Section PAR 14-080 International Research in Infectious Diseases Chair-elect, American Committee on Arthropod-Borne Viruses C. Contribution to Science The major research area in which I’ve contributed is arboviral epidemiology. My early publications directly addressed the fact that transmission of Rift Valley fever virus (RVFV) is often overlooked in endemic communities. We demonstrated a great burden of exposure both during and in between recognized outbreaks in both human (1-3) and animal (4) populations. This body of work changed the areas thought to be at risk for RVFV transmission and provided evidence for unrecognized transmission in both adults and children. I served as the primary investigator or co-investigator in these studies. 1. LaBeaud AD, Ochiai Y, Peters CJ, Muchiri EM, King CH. Spectrum of Rift Valley fever virus transmission in Kenya: insights from three distinct regions. Am J Trop Med Hyg. 2007 May;76(5):795800. PMCID: PMC2367216. 2. LaBeaud AD, Muchiri EM, Ndzovu M, Mwanje MT, Muiruri S, Peters CJ, King CH. Interepidemic Rift Valley fever virus seropositivity, northeastern Kenya. Emerg Infect Dis. 2008 Aug;14(8):1240-6. PMCID: PMC2600406. 3. LaBeaud AD, Muiruri S, Sutherland LJ, Dahir S, Gildengorin G, Morrill J, Muchiri EM, Peters CJ, King CH. Postepidemic Analysis of Rift Valley Fever Virus Transmission in Northeastern Kenya: A Village Cohort Study. PLoS Neglected Tropical Diseases Journal, 2011 Aug;5(8):e1265. Epub 2011 Aug 16. PMCID: PMC3156691. 4. LaBeaud AD, Cross P, Getz W, Glinka A, King CH. Rift Valley fever virus infection in African buffalo (Syncerus caffer) herds in rural South Africa--Evidence of inter-epizootic transmission. Am J Trop Med Hyg. 2011 Apr;84(4):641-6. PMCID: PMC3062463. 5. Gray GC, Anderson BD, LaBeaud AD, Heraud JM, Fèvre EM, Andriamandimby SF, Cook EA, Dahir S, de Glanville WA, Heil GL, Khan SU, Muiruri S, Olive MM, Thomas LF, Merrill HR, Merrill ML, Richt JA. Seroepidemiological Study of Interepidemic Rift Valley Fever Virus Infection Among Persons with Intense Ruminant Exposure in Madagascar and Kenya. Am J Trop Med Hyg. 2015 Oct 12. The spectrum of human RVF disease is broad and the factors that determine severe vs. mild disease are not well understood. It is likely that immune (5), demographic (6) and genetic (7) factors are all important to determine clinical manifestations of disease. I served as the primary investigator or co-investigator in these studies. 6. Newman-Gerhardt S, Muiruri S, Muchiri EM, Peters CJ, Morrill, Lucas AH, King CH, Kazura J, LaBeaud AD. Potential for Autoimmune Pathogenesis of Rift Valley Fever Virus Retinitis, Accepted for publication, American Journal of Tropical Medicine & Hygiene, 2013 Sep;89(3):495-7 7. LaBeaud AD, Pfeil S, Muiruri S, Dahir S, Sutherland LJ, Traylor Z, Gildengorin G, Muchiri EM, Morrill J, Peters CJ, Hise AG, Kazura JW, King CH. Factors Associated with Severe Human Rift Valley Fever in Sangailu, Garissa County, Kenya. PLoS Negl Trop Dis 9(3): e0003548. doi:10.1371/journal.pntd.0003548. 8. Hise AG, Traylor Z, Hall NB, Sutherland LJ, Dahir S, Ermler ME, Muiruri S, Muchiri EM, Kazura JW, LaBeaud AD, King CH, Stein CM. Association of Symptoms and Severity of Rift Valley Fever with Genetic Polymorphisms in Human Innate Immune Pathways. PLoS Negl Trop Dis 9(3): e0003584. doi:10.1371/journal.pntd.0003584 In addition to work on RVFV above, I expanded my work to include other arboviruses of human importance. Again we have demonstrated a great burden of exposure to many pathogens (8) and a large proportion of infected vectors in our study sites (9). More recently, we have uncovered intense transmission of viruses previously unrecognized (11). This work continues to uncover unrecognized transmission of these pathogens and provide evidence for resultant human infection and disease. The disease burden is due not only to the acute febrile illness, but also to the long-term health consequences that result from arboviral infection (12). I served as the primary investigator or co-investigator in these studies. 9. Sutherland LJ, Cash AA, Sang RC, Huang YS, Malhotra I, King CL, Moormann AM, Weaver SC, King CH, and LaBeaud AD. Serological Evidence of Arboviral Infections among Humans in Kenya. American Journal of Tropical Medicine & Hygiene, 2011 Jul;85(1):158-61. PMCID: PMC3122361. 10. LaBeaud AD, Sutherland LJ, Muiruri S, Gray L, Zimmerman PA, Hise AG, King CH. Arbovirus Prevalence in mosquitoes, Kenya. Emerging Infectious Diseases Journal, 2011 Feb: 17(2):233-41. PMCID: PMC3204744. 11. LaBeaud AD, Banda T, Brichard J, Borland E, Mungai PL, Mutuku FM, Gildengorin V, Pfeil S, Teng CY, Long K, Heise M, Muchiri EM, Powers AM, Kitron U, King CH. High rates of o'nyong nyong and chikungunya virus transmission in coastal Kenya. PLoS Negl Trop Dis, 2015; 9(2): e0003436. doi:10.1371/journal.pntd.0003436 12. LaBeaud AD, Bashir F, King CH. Measuring the Burden of Arboviral Diseases: The Spectrum of Morbidity and Mortality from Four Prevalent Infections. Population Health Metrics, 2011 Jan 10;9(1):1. PMCID: PMC3024945. As a pediatrician, I have always been interested in the clinical manifestations of arboviruses and differences between child and adult presentations (13,14). Children are often excluded from outbreak studies, so little is known about the specific risk factors of (12), health consequences to (13), or optimal prevention strategies for (14) children. I served as the primary investigator or co-investigator in these studies. 13. LaBeaud AD, Kile JR, Kippes C, King CH, Mandalakas AM. Exposure to West Nile virus during the 2002 epidemic in Cuyahoga County, Ohio: a comparison of pediatric and adult behaviors. Public Health Rep. 2007 May-Jun;122(3):356-61. PMCID: PMC1847498. 14. LaBeaud AD, Lisgaris MV, King CH, Mandalakas AM. Pediatric West Nile virus infection: neurologic disease presentations during the 2002 epidemic in Cuyahoga County, Ohio. Pediatr Infect Dis J. 2006 Aug;25(8):751-3. 15. LaBeaud AD, Glinka A, Kippes C, King CH. School-based health promotion for mosquito-borne disease prevention in children. J Pediatr. 2009 Oct;155(4):590-2. PMCID: PMC3104726. Unrelated to arboviruses, but intensely important for children’s health, we have performed studies to evaluate the effects of parasitism on childhood vaccine response in our communities. Although parasites are known to disrupt immunity, our studies suggest a novel idea that priming of the fetal immune system in utero by parasites effects later immune function in childhood (15, 16). This research has important policy implications for mass drug administration programs for parasite control, mass vaccination campaigns in parasite-endemic areas, and supplies crucial data regarding the effects of parasites on child health and development (17). I served as the primary investigator or co-investigator in these studies. 16. Labeaud AD, Malhotra I, King MJ, King CL, King CH. Do antenatal parasite infections devalue childhood vaccination? PLoS Negl Trop Dis. 2009 May 26;3(5):e442. PMCID: PMC2682196. 17. Malhotra I, McKibben M, Mungai P, McKibben E, Wang X, Sutherland LJ, Muchiri E, King CH, King CL, LaBeaud AD. Effect of Antenatal Parasitic Infections on Anti-vaccine IgG levels in Children: A Prospective Birth Cohort Study in Kenya. PLoS Negl Trop Dis 2015; 9(1): e0003466. doi:10.1371/journal.pntd.0003466 18. LaBeaud AD, Singer MN, McKibben M, Mungai P, Muchiri EM, McKibben E, Gildengorin G, Sutherland LJ, King CH, King CL, Malhotra I. Parasitism in Children Aged Three Years and Under: Relationship Between Infection and Growth in Rural Coastal Kenya. PLoS Negl Trop Dis 9(5): e0003721. doi:10.1371/journal.pntd.0003721 A complete list of my published work is available at: http://www.ncbi.nlm.nih.gov/sites/myncbi/1PyVBywa_Wkt/bibliography/40449230/public/?sort=date&direction=ascending D. Research Support Ongoing Research Support 1/2017-12/2017 Stanford Child Health Research Institute: The Spectrum of Zika Virus Disease in Grenada; Principal Investigator: AD LaBeaud; Goal: To determine factors associated with mother to child transmission of ZIKV and the long-term consequences of congenital ZIKV disease. Role: Awardee/PI 9/2016-8/2018 NIH, R21TW010536; Neurodevelopment and Vector-borne Diseases: Building Research Capacity in the Tropics; Principal Investigators: AD LaBeaud and R Waechter; Goal: To estimate the effect of peripartum chikungunya virus infection on child neurodevelopment. Role: Co-PI 9/2016-8/2018 Stanford Institute for Immunity, Transplantation and Infection Seed Interdisciplinary Research Award: Characterizing the Effects of Antenatal Parasitic Infection on Fetal Immune System Development; Principal Investigator: AD LaBeaud; Goal: To identify immune signatures of parasite fetal priming using both functional and genomic T cell investigations, and analysis of B cell repertoires. Role: Awardee/Co-PI 7/2016-6/2018 Stanford Woods Institute Environmental Venture Project grant; Predicting Dengue Transmission in a Changing Climate to Improve Mosquito Control; Principal Investigators: AD LaBeaud and E Mordecai; Goal: To use mathematical models, field data, and remote sensing to predict dengue transmission, and to apply the predictive models to improve vector control in Kenya and Ecuador. Role: Co-PI 1/2016-12/2016 Center for Innovation in Global Health Seed Grant, Stanford University; Predicting Dengue Transmission in a Changing Climate; Principal Investigators: AD LaBeaud and E Mordecai; Goal: To develop and validate predictive models of dengue transmission based on climate data. Role: Awardee/Co-PI 9/2015-8/2020 Bechtel Faculty Scholar Award, Stanford Child Health Research Institute; Integrated Vector Management as a Strategy for Reduced Disease Risk in a Newly Discovered Region of Dengue Fever in Africa; Principal Investigator: AD LaBeaud; Goal: To measure the impact of school- and household-based educational interventions on mosquito larval control in Kenya. Role: Awardee/PI 7/2015-6/2020 NIH, U24AI118648; Miniaturized Automated Whole Blood Cellular Analysis System; Principal Investigators: AD LaBeaud and H Maecker; Goal: To create an easy to use automated system for stimulation and storage of small-volume whole blood samples for functional assays, and to validate the system’s performance in a cohort of pediatric subjects seen at point-of-care clinics in Kenya. Role: Co-PI 7/2013-6/2018 NIH, R01AI102918; The Burden of Chikungunya and Dengue Transmission, Infection and Disease in Kenya; Principal Investigator: AD LaBeaud; Goal: To estimate the burden of infection and disease from dengue and chikungunya viruses in Kenya. Role: PI 11/2012-10/2016 OPP1066865 Bill and Melinda Gates Foundation Healthy Growth Award; Enhancing Infant Immunity: Effect of Early Maternal Treatment for Parasitic Infections; PI: Charles King, MD; Goal: To examine the impact of maternal infections during pregnancy on the tolerization of immune response in infants, and its related effects on vaccine efficacy (coastal Kenya). Role: Co-investigator Completed Research Support (last 3 years only) 8/2015-7/2016 American Society of Tropical Medicine and Hygiene, Robert E. Shope International Fellowship in Infectious Diseases; Characterization of Immune Factors of Severe and Chronic Chikungunya Disease in Grenada, West Indies; Role: Mentor 3/2012-2/2014 NIH PNWRCE New Research Project Award, “The Burden of Chikungunya and Dengue Infection in Kenya;” PI: Desiree LaBeaud, MD; Goal: To quantify the prevalence of chikungunya and dengue virus exposure in Kenya and then detect and predict spatial and temporal patterns of transmission; Role: PI 4/2009-2/2014 NIH, U54AI057160; Midwest Regional Center of Excellence Program Project Award: Innate Immunity of Rift Valley Fever Virus; PI: Herbert Virgin; Program Leader: James Kazura, MD; Goal: To evaluate the contribution of innate immunology and genetics to the clinical spectrum of human RVF; Role: Co-I 4/2010-4/2013 NIH, 1R03HD058587; The effects of polyparasitism on vaccine response; PI: Desiree LaBeaud, MD and Indu Malhotra, PhD; Goal: To test whether antenatal parasitic infections and treatments impact postnatal response to H. influenzae type B, diphtheria, hepatitis B virus, and polio vaccines; Role: PI 1/2011-6/2013 Department of Homeland Security: Center of Excellence for Emerging Zoonotic Animal Diseases, "Risk Factors for Rift Valley Fever Virus Infections among Herders in Kenya, Saudi Arabia, South Africa, and Madagascar"; PI: Gregory Gray, MD; Goal: To evaluate the risk factors for RVFV infection in herders; Role: Kenya Site PI