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UNDERSTANDING CANCER Cancer’s Seven Warning Signs What is Cancer? 1. Change in bowel or bladder habits. 2. A sore that does not heal. 3. Unusual bleeding or discharge. 4. Thickening or lump in breast or elsewhere. 5. Indigestion or difficulty in swallowing. 6. Obvious change in wart or mole. 7. Nagging cough or hoarseness. What is a Carcinogen? Cancer is a destructive (malignant) growth of cells which invades nearby tissues and may metastasize (spread) to other areas of the body. Dividing rapidly, these cells tend to be very aggressive and out of control. In contrast, a benign tumor is simply a localized mass of slowly multiplying cells resembling its original tissue and are seldom life-threatening. Factors found in the environment which may increase the risk of cancer are called carcinogens. These include: • Cigarrette Smoking • Exposure to industrial agents and chemicals • Radiation • Pollution • Alcohol • Some viruses Normal cells The Diagnosis 1. How Does Cancer Spread? Most benign cells are considered harmless unless their size or location threaten nearby structures. Any sign of cancer should be detected and treated early for a better chance of a full recovery. The diagnosis of malignant cancer is determined by a microscopic examination of sampled (biopsied) tissue. Measuring the extent the cells have spread, called staging, can be done using a variety of imaging techniques. Computerized Axial Tomography (CAT-scan) is a rotating X-ray machine used to take cross-sectional pictures of specific tumors. Magnetic Resonance Imaging (MRI) uses a magnetic field and radiofrequency waves to make detailed images of some parts of the body, like the brain. If you have a warning signal, see your doctor. Early detection and self-examination are most important in cancer detection. Most experts believe that repeated or long term exposure to these elements damages normal cells. Heredity is another factor which plays a role in the risk of breast, colon and skin cancer. Cancer cells Precancerous cells (from the American Cancer Society) The venous system: Cancer cells may travel through the veins, often to the liver and the lungs. Cancer Incidence by Site and Sex (based on information from the American Cancer Society) *Excluding nonmelanoma skin cancer and carcinoma in situ. 3% Melanoma of the skin 3% 2% Oral 4% Larynx 2% 4% Lymphoma 4% 19% Lung 11% 36% Breast Stomach 3% 3% Pancreas 3% 2% Kidney 3% 14% Colon & Rectum 14% 4% Ovary 8% Uterus 2% Bladder 7% Prostate 22% 2% Leukemia 3% Superior mesenteric artery and vein Middle colic vein Cancer cells may invade nearby tissues or metastasize (spread) to other organs. There are three ways in which cancer cells may move to other tissues: Transverse colon Ascending colon The four stages of malignant cancer are determined by the spread of the cancer cells. This classification helps physicians develop a treatment plan specific to each individual cancer. Lymph nodes 2. Primary cancer Cancer 3. Epithelium The lymphatic system: Cancer cells may move through this series of channels from the tissues to lymph nodes and eventually to the circulatory system. Seeding: Cancer may penetrate an organ, moving into a body cavity (chest or abdominal space) and spread throughout that area. Lymph nodes Liver Lymph nodes Pancreas Metastatic cancer Metastatic cancer in lymph nodes Dermis Stage I: Bile duct Lymph nodes The cancer is small, localized and limited. Primary cancer Metastatic cancer Primary cancer Stage IV: Mammary ducts Cancer Treatments Metastasis (spread) of the tumor occurs in other tissues of the body. Aorta Mammary glands Due to the variety of cancers, the ideal treatment can range from observation to complicated surgical removal with aggressive therapy. Surgery, radiation therapy and chemotherapy can be used in combination or as individual treatments. Some cancers may also be treated with hormone or biological therapy which can be described by a physician. Successful treatment may lead to remission (a condition when signs of the disease are gone). Left lung Stage II: Stage III: Local spreading occurs in the organ and lymph nodes. Achieving a Healthy Lifestyle Cancer cells invade neighboring tissues and lymph nodes. Capillary Normal cells Surgery Radiation beam As a method of local treatment, the diseased part of the body is removed. Neighboring healthy lymph nodes and tissues may also be removed to help control the spread of the cancer. Chemotherapy • Maintaining low body fat. Epithelium Radiation Therapy 9756 • Selecting a balanced diet high in fiber, low in fat. • Limiting alcohol intake. Red blood cell High energy rays, focused in a beam, are used to damage the cancer cells and stop their reproduction. This local therapy is used to shrink a cancer’s size either before surgical removal or after, to kill any remaining cancer cells. Side effects may range from minimal to moderate including: tiredness, skin rashes, and a decrease in infectionfighting white blood cells. Cancer cells Understanding cancer and its cause is the best way to develop a healthier lifestyle and avoid exposure to its risks. Some preventative measures include: Chemotherapy Normal cells Cancer Synthetic drugs, given at prearranged, timed intervals, are used to disrupt a cancer cell’s ability to grow. These drugs act, via the blood, on the entire body. In addition to treating the cancer, they may cause temporary side effects in fast growing cells like those of the blood, stomach and hair. Common side effects are hair loss, nausea, vomiting and a reduced number of white blood cells. These side effects increase the chance of infection. • Doing self examinations. • Getting regular check-ups. It is very important to follow your physician’s instructions and to seek the support of family and friends. Cancer-related support groups are also available to discuss issues surrounding cancer. ©1997, 1999 Anatomical Chart Co., Skokie, Illinois. Medical Illustrations by Marguerite Aitken.