Download Slide () - Anesthesiology - American Society of Anesthesiologists

From: Sevoflurane Enhances γ-Aminobutyric Acid Type A Receptor Function and Overall Inhibition of Inspiratory Premotor
Neurons in a Decerebrate Dog Model
Anesthes. 2005;103(1):57-64.
Figure Legend:
Fig. 7. ( Left ) Simplified diagram of the pontomedullary pattern generator that transforms tonic excitatory drive into rhythmic
neuronal discharge patterns. (From top to bottom ) Excitatory drive to the respiratory system is mostly tonic and arises from
central and peripheral chemoreceptors and also from other central networks, e.g. , the reticular formation. The drive activates
neurons in the pre-Bötzinger region, which through reciprocal connections develop two respiratory phases. Additional neuronal
connections are required to generate a distinct functional discharge pattern. Tonic excitatory drive and phasic excitation reach the
premotor
neurons5/10/2017
of the caudal ventral
respiratory
group.
Inspiratory
neurons reciprocally
excite each other (“selfDate of download:
Copyright
© 2017
American
Societypremotor
of Anesthesiologists.
All rights reserved.
reexcitation,” dotted line ). Phasic excitation is relayed by the premotor neurons to the motoneurons. The neurons of timing and