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A: Systolic dysfunction is represented by shifting of the isovolumic pressure-volume curve to the right (dashed line), thus decreasing stroke volume. The ventricle can compensate by (B) shifting the diastolic pressure-volume relationship rightward (dashed line) by increasing left ventricular volume or elasticity, (C) increasing contractile state (dashed line) by activation of circulating catecholamines, and (D) increasing filling or preload (a to a′). Source: Cardiovascular Disorders: Heart Disease, Pathophysiology of Disease: An Introduction to Clinical Medicine, 7e Citation: Hammer GD, McPhee SJ. Pathophysiology of Disease: An Introduction to Clinical Medicine, 7e; 2013 Available at: http://mhmedical.com/ Accessed: May 09, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved
