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150 Human Anatomy & Physiology Connective & Muscle Tissues, Ch. 4 Tissues Groups of cells similar in structure and function The four types of tissues Epithelial Connective: A main focus of this lecture Muscle: A main focus of this lecture Nerve Functions of Connective Tissue Binding and support __________________ Insulation Transportation Characteristics of Connective Tissue Found throughout the body; most abundant and widely distributed in primary tissues Connective tissues have: Mesenchyme as their common tissue of origin Varying degrees of vascularity Nonliving extracellular matrix, consisting of ground substance and ____________ Structural Elements of Connective Tissue Fibers - collagen, elastic, or reticular Cells - fibroblasts, chondroblasts, osteoblasts, and hematopoietic stem cells Ground Substance Interstitial (tissue) fluid Adhesion proteins - fibronectin and laminin Proteoglycans - glycosaminoglycans (GAGs) Function: A molecular sieve through which nutrients diffuse between blood capillaries and cells Connective Tissue Major Types of Connective Tissue Connective tissue proper Cartilage Bone ___________ Connective & Muscle Tissues: Page 1 of 4 Major Cell Types of C.T. _____________ - connective tissue proper Chondroblasts - cartilage Osteoblasts - bone Hematopoietic stem cells - ___________ White blood cells, plasma cells, macrophages, and mast cells Fibers Collagen - tough; provides high tensile strength Elastic - long, thin fibers that allow for stretch Reticular - branched collagenous fibers that form delicate networks Embryonic Mesenchyme - embryonic connective tissue Gel-like ground substance found in the embryo with fibers and star-shaped mesenchymal cells Gives rise to all other connective tissues Connective Tissue Proper: Loose Areolar connective tissue Description: Gel-like matrix with all three connective tissue fibers - Fibroblasts, macrophages, mast cells, and some white blood cells Function: Wraps and _______________ organs Location: ___________ distributed throughout the body Adipose connective tissue Description: Matrix similar to areolar connective tissue with closely packed adipocytes Function: Reserves food stores, insulates against heat loss, and supports and protects Location: Found under skin, around kidneys, within abdomen, and in breasts Reticular connective tissue Description: Loose ground substance with ___________ fibers - Reticular cells lie in a fiber network Function: Forms a soft internal skeleton, or stroma, that supports other cell types Location: Found in lymph nodes, bone marrow, and the spleen Connective Tissue Proper: Dense Regular Dense Regular connective tissue Description: Parallel collagen fibers with a few __________ fibers Major cell type: Fibroblasts Function: Attaches muscles to bone or to other muscles, and bone to bone Location: Found in tendons, ligaments, and aponeuroses Connective & Muscle Tissues: Page 2 of 4 Connective Tissue Proper: Dense Irregular Dense Irregular connective tissue Description: Irregularly arranged ____________ fibers with some elastic fibers Major cell type: Fibroblasts Function: Withstands tension in _________ directions providing structural strength Location: Found in the dermis, submucosa of the digestive tract, and fibrous organ capsules Connective Tissue: Cartilage Hyaline cartilage Description: Amorphous, firm matrix w/ imperceptible network of collagen fibers (costal cart.) Major Cell Type: Chondrocytes lie in lacunae Function: Supports, reinforces, cushions, and resists compression Location: Found in embryonic skeleton, the end of long bones, nose, trachea, and larynx Elastic Cartilage Description: Similar to hyaline cartilage but with more elastic fibers; Maintains shape and structure while allowing flexibility (Similar to hyaline cart.; more elastic fibers) Function: Maintains shape and structure while allowing flexibility Location: Supports external ______ (pinna) and the epiglottis Fibrocartilage Cartilage Description: Matrix similar to hyaline cartilage but less firm with thick collagen fibers Function: Provides tensile strength and absorbs compression shock Location: Found in intervertebral discs, the pubic symphysis, and in discs of ________ joint Connective Tissue: Bone (Osseous Tissue) Description: Hard, calcified matrix with collagen fibers found in bone - Marrow inside bones is the site of hematopoiesis Major Cell Type: Osteocytes are found in lacunae and are well vascularized Function: Supports, protects, and provides levers for muscular action ( - Stores calcium, minerals, and fat Connective Tissue: Blood Description: Red and white cells in a fluid matrix (plasma) Function: Transports respiratory gases, nutrients, and wastes Location: Contained within blood vessels Epithelial Membranes Cutaneous: Skin (Stratified epitheliel on top of C.T.) Mucous Lines body cavities open to the exterior (e.g., digestive and respiratory tracts) Serous Moist membranes found in closed ventral body cavity Connective & Muscle Tissues: Page 3 of 4 Muscle Tissue: General Function: Movement Description: Well vascularized, inervated cells that can contract (shorten) due to specialized actin/myosin filaments combinations called myofilaments Three types of muscle tissue: Skeletal, Smooth, and Cardiac Smooth Muscle Description: Sheets of spindle-shaped cells with central nuclei that have no striations; ____________ Function: Propels substances along internal passageways (i.e., peristalsis) Location: Found in the walls of hollow organs (e.g. stomach, urinary bladder, and respiratory passages) Cardiac Muscle Description: Branching, striated, uninucleate cells interlocking at intercalated discs; _____________ Function: Propels blood into the circulation Location: Found in the walls of the heart Skeletal Description: Long, cylindrical, multinucleate cells with obvious striations (banded appearance); ________________! Function: Initiates and controls voluntary movement Location: Found in skeletal muscles that attach to bones or skin Tissue Trauma Causes inflammation, characterized by: Dilation of blood vessels, Increase in vessel permeability Redness, heat, swelling, and pain Tissue Repair Organization and restored blood supply The blood clot is replaced with granulation tissue Regeneration and fibrosis Surface epithelium regenerates and the scab detaches Results in a fully regenerated epithelium with underlying scar tissue Nervous Tissue Description: Branched neurons with long cellular processes and support cells Function: Transmits electrical signals from sensory receptors to effectors Location: Found in the brain, spinal cord, and peripheral nerves Connective & Muscle Tissues: Page 4 of 4