Download Avian influenza receptor expression in H5N1

TUGAS : EPIDEMIOLOGI KONTEMPORER
Dosen : Prof.Dr.drg.A.Arsunan Arsin,M.Kes.
MAHASISWA : MUHLIS NATSIR
TABEL SINTESA : AVIAN INFLUENZA
No
Peneliti (Tahun)
Masalah Utama
1
M.E. Thomas,et al
Preventive Veterinary
Medicine 2004.
Risk factors for the
introduction of high
pathogenicity Avian
Influenza virus into
poultry farms during
the epidemic in the
Netherlands in 2003
2
Lu Yao,et al
The FASEB Journal
2008
Avian influenza
Human tissue
receptor expression
samples
in H5N1-infected and
noninfected human
tissues
Subjek
173 infected and
401 uninfected
commercial
poultry farms
Karakteristik
Instrumen
- Data sekunder
-
Pemeriksaasn
laboratorium
Temuan
Metode Desain
Case control
We found an increased risk of HPAI
study
virus introduction in layer finisher type
poultry: OR = 2.05 (95% confidence
interval, CI = 1.29–3.27). An
explanation for this increased risk is
the high number of contacts between
these farms, especially via cardboard
egg trays used for removal of eggs
during the epidemic. Our analysis did
not indicate significant differences
between the infected and uninfected
farms with regard to housing type,
presence of cattle or pigs
Deskriptif study AIV-Rs were detected on type II
pneumocytes; a limited number of
epithelial cells of the upper respiratory
tract; and the bronchi, bronchioli, and
trachea; as well as on Kupffer cells,
glomerular cells, splenic T cells, and
neurons in the brain and intestines.
AIV-Rs were abundantly present in the
respiratory tract and lungs. They were
also detected on Hofbauer cells,
glomerular cells, splenic B cells, and in
the liver
3
Anthony W. Mounts,
et al,
The Journal of
Infectious Diseases
1999
Case-Control Study
of Risk Factors for
Avian Influenza A
(H5N1) Disease,
patients
hospitalized for
influenza A
(H5N1) disease
-
Data sekunder
Kuesioner
Specimen
collection and
testing
Case-control
study
4
Endang R.
Sedyaningsih,et al ,
The journals
infectious diseases
2007
Epidemiology of
Cases of H5N1 Virus
Infection
in Indonesia, July
2005–June 2006
persons with
suspected H5N1
virus infection
-
Data sekunder
Kuesioner
Observasional
study
9 (64%) of 14 case patients and
11 (29%) of 38 controls reported
poultry exposure (visiting either
a poultry stall or a retail market selling
live poultry) in the week before illness
onset (OR, 4.5; 95% CI, 1.2–21.7;P=
.045;). Activities related to poultry
preparation or eating, contact
with wild birds, travel, or exposure to a
person with an influenza-like illness
were not significantly different between
casesubjects and controls. One (8%)
of 13 case subjects and noneof 35
controls reported exposure to a person
known to havebeen infected with
influenza A (H5N1) virus (P = .5).
Playing
in an indoor playground the week
before illness was reportedmore
frequently by controls (32%) than by
case subjects (0%) (OR, 0.0; 95% CI,
0.020.5; P = .013).
From July 2005 through June 2006, 54
cases of H5N1 virus infection were
identified, with a case fatality
proportion of 76%. The median age
was 18.5 years, and 57.4% of patients
were male. More than one-third
of cases occurred in 7 clusters of
blood-related family members.
Seventy-six percent of cases were
associated with poultry contact, and
the source of H5N1 virus infection was
5
6
7
Justin R. Ortiz,et al,
The journals
infectious diseases
2006
Lack of Evidence of
Avian-to-Human
Transmission
of Avian Influenza A
(H5N1) Virus among
Poultry
Workers, Kano,
Nigeria, 2006
295 poultry
workers and 25
laboratory
workers with
suspected
exposure to
H5N1 virus
-
Kuesioner
Data sekunder
Tes laboratorium
Deskriptif study
Thanawat Tiensin,et
al, The Journal of
Infectious
Diseases,2007
Transmission of the
Highly Pathogenic
Avian
Influenza Virus H5N1
within Flocks during
the 2004 Epidemic in
Thailand.
-
Data sekunder
Kuesioner
Cross sectional
Study
Iain Stephenson,et al,
The Journal of
Infectious Diseases
2005
Cross-Reactivity to
Highly Pathogenic
Avian Influenza
H5N1 Viruses after
Vaccination
with Nonadjuvanted
and MF59Adjuvanted
Influenza
A/Duck/Singapore/97
(H5N3)
Vaccine: A Potential
Thai chicken
flocks that had
tested positive
for H5N1
virus by virus
isolation during
July–November
2004
healthy
volunteers 18–45
years old who
provided signed,
informed consent
-
Kuesioner
Tes laboratorium
Geometric mean
titers (GMTs)
Clinical study
not identified in 24% of cases
The 295 poultry workers reported a
median of 14 days of exposure to
suspected or confirmed H5N1infected poultry without antiviral
chemoprophylaxis and with minimal
personal protective equipment. Among
25
laboratory workers, all handled poultry
specimens with suspected H5N1 virus
infection. All participants tested
negative for H5N1 neutralizing
antibodies
Although the point estimates of _ of
backyard chickens and fighting cocks
raised together were lower than those
of laying hens and broiler chickens,
this difference was not statistically
significant
Antibody responses to 3 doses of
nonadjuvanted
vaccine were poor and were higher
after MF59-adjuvanted vaccine, with
seroconversion rates to
A/HongKong/156/97,
A/HongKong/213/03,
A/Thailand/16/04, and
A/Vietnam/1203/04 of 100% (P <
.0001), 100% (P < .0001), 71%
(P=.0004), and 43% (P=.0128) in 14
subjects,
8
9
Larisa V.et al,
The Journal of
Infectious Diseases
2008
Anthony W.
Mounts,et al, The
Journal of Infectious
Diseases 1999
Priming Strategy
Characterization of
Influenza
A/HongKong/156/97
(H5N1) Virus in a
Mouse
Model and Protective
Effect of Zanamivir
on H5N1 Infection in
Mice
Case-Control Study
of Risk Factors for
Avian Influenza A
(H5N1) Disease,
Hong Kong, 1997
Sample influenza virus from a
patient who died
of influenza viru s
infection in May
0f 1997.
Tes laboratorium
Eksperimental
laboratorium
-
-
15 subjects who
had been
hospitalized
for febrile
respiratory illness
in Hong Kong
during November
(n = 4) and
December (n =
11) 1997 and
who had either
viral
culture or
serologically
confirmed (4-fold
rise in antibody
titer)
influenza A
Kuesioner
Serologic test
Case control
study
-
-
A/HongKong/156/97 (H5N1), the
first virus of H5N1 subtype isolated
from a human host, is highly
virulent in the mouse model and
can infect mouse lungs without
requiring adaptation
Zanamivir, a novel neuraminidase
inhibitor, is effective at decreasing
replication of the virus in vitro. In a
model of lethal challenge in mice,
zanamivir reduces lung titers of the
virus and decreases morbidity and
mortality
Exposure to live poultry (by visiting
either a retail poultry stall or a
market selling live poultry) in the
week before illness began was
significantly associated with H5N1
disease (64% of cases vs. 29% of
controls, odds ratio, 4.5, P = .045).
By contrast, travel, eating or
preparing poultry products, recent
exposure to persons with
respiratory illness, including
persons with known influenza A
(H5N1) infection, were not
associated with H5N1 disease..
10.
Carolyn Buxton
Bridges,et al,
The Journal of
Infectious Diseases
2000
Risk of Influenza A
(H5N1) Infection
among Health Care
Workers Exposed
to Patients with
Influenza A (H5N1),
Hong Kong
11
Peter N.
Thompson,et al,
Preventive Veterinary
Medicine 2008.
Risk factors for
seropositivity to H5
avian influenza virus
in ostrich farms in
the Western Cape
Province, South
Africa
(H5N1) infections
Health Care
Workers
-
ostrich farms in
the Western
Cape Province of
South Africa (367
farms, of which
82 were
seropositive to
H5 AI virus).
Kuesioner
Serologic test
Cross sectional
study
-
Eight (3.7%) of 217 exposed and 2
(0.7%) of 309 nonexposed HCWs
were H5N1 seropositive (P = .01).
The difference remained significant
after controlling for poultry
exposure (P = .01)
Kuesioner
Data sekunder
Case control
study
-
Increased risk of seropositivity was
associated with reduced frequency
of cleaning of feed troughs
(<1×/week vs. >1×/week), both
overall (odds ratio (OR) = 4.5; 95%
confidence interval (CI): 1.5, 13.3)
and in the Southern Cape
(OR = 53.6; 95% CI: 3.3, 864), and
with failure to clean and disinfect
transport vehicles, both overall
(OR = 2.3; 95% CI: 1.1, 4.8) and in
the Klein Karoo (OR = 2.6; 95% CI:
1.1, 6.5).
Increased risk of seropositivity was
also associated with increasing
frequency of contact of ostriches
with certain wild bird species:
overall with white storks (Ciconia
ciconia), in the Southern Cape with
gulls (Larus spp.), and in the Klein
Karoo with Egyptian geese
(Alopochen aegyptiaca).
-
12
M.J. PantinJackwood,et al, Virus
Research 2007
Age at infection
affects the
pathogenicity of
Asian highly
pathogenic avian
influenza H5N1
viruses in ducks
Ducks
-
Tes laboratorium
Deskriptif study
-
13
Marion Koopmans,et
al, The Lancet
infectious diseases
2004.
Transmission of
H7N7 avian
influenza A virus to
human beings during
a large outbreak in
commercial poultry
farms in the
Netherlands
All workers in
poultry farms,
poultry farmers,
and their families
-
Kuesioner
Tes laboratorium
Deskriptif study
-
14
I. East,et al,
Preventive Veterinary
Medicine 2006
A cross-sectional
survey of Australian
chicken farms to
identify risk factors
associated with
seropositivity to
753 Australian
chicken farms
-
Kuesioner
Serologic test
Cross sectional
study
-
the pathogenicity of circulating
H5N1 HPAI viruses in ducks varies
depending on the virus strain and
the age of the duck and correlates
with the level of viral replication in
tissues. High titers of virus in
organs, high viral shedding, and
variable mortality enable ducks to
circulate H5N1 HPAI viruses.
453 people had health
complaints—349 reported
conjunctivitis, 90 had influenza-like
illness, and 67 had other
complaints. We detected A/H7 in
conjunctival samples from 78
(26·4%) people with conjunctivitis
only, in five (9·4%) with influenzalike illness and conjunctivitis, in two
(5·4%) with influenza-like illness
only, and in four (6%) who reported
other symptoms. Most positive
samples had been collected within
5 days of symptom onset. A/H7
infection was confirmed in three
contacts (of 83 tested), one of
whom developed influenza-like
illness
In the layer sector,,increased risk of
seroprevalence was associated
with increasing age of the chickens,
and decreased risk when the
nearest-neighbour poultry farm was
>1.0 km distant (odds ratio
Newcastle-disease
virus
15
I. Nyoman Kandun, et
al, The New England
Journal o f Medicine
2006
Three Indonesian
Clusters of H5N1
Virus
Infection in 2005
(OR) = 0.30). In the chicken-meat
sector, increased risk of
seroprevalence was associated
with location in the Sydney basin
(OR = 13.67), eastern Victoria
(OR = 26.10) or western Victoria
(OR = 5.43), and decreased risk
when the nearest-neighbour poultry
farm was greater than 0.5 km
distant (OR = 0.34). In the breeder
sector, increased risk of
seroprevalence was associated
with increasing age of the chickens,
the presence of wild birds on the
farm (OR = 5.28) and location in
eastern Victoria (OR = 16.19)
persons
hospitalized
with laboratory
evidence of
H5N1 virus
infection from
June through
October
2005.
-
Data sekunder
Deskriptif study
-
-
Clusters of human infection with
clade 2 H5N1 viruses included
mild, severe, and fatal cases
among family members.
Mild illness in children was
documented in two clusters. The
median age of the eight patients
was 8.5 years (range, 1 to 38).
Four patients required mechanical
ventilation, and four of the eight
patients (50%) died. In each
cluster, patients with H5N1 virus
infection were members of the
same family, and most lived in the
same home