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GENERAL ANATOMY & PHYSIOLOGY—Introduction to the Human Body Dr. V.P.C.Rajakaruna MBBS (COLOMBO) Objectives • Introduction to anatomy and physiology • Life • Levels of Organization • Organ Systems • Body divisions and cavities • Homeostasis Anatomy--the study of the structure of the human body. Physiology—the study of the function of the human body. Life Characteristics of Life • Movement – Change in position of organism or parts of organism • Responsiveness – Reaction to change (inside or outside of body) • Growth – Increase in size without change in shape • Respiration – Use of oxygen • Digestion – Breakdown of food substances into simpler forms Characteristics of Life • Absorption – Passage of substances through membranes and into body fluids. • Circulation – Movement of substances throughout body • Assimilation – Changing absorbed substances into chemically different forms • Excretion – Removal of waste products Levels of Organization The body is organized according to levels of complexity. The lowest level of complexity is the atom. The highest level of complexity is the organism. Levels of Organization Here are the levels from lowest to highest complexity: Organism Atom System Molecule Macromolecule Organelle Cell Organ Tissue Organ Systems • • • • • • • • • • • Integumentary Skeletal Muscular Nervous Endocrine Lymphatic Digestive Respiratory Cardiovascular Urinary Reproductive Organ Systems The integumentary system consists of the hair, skin, nails, sweat glands, and sebaceous glands. Its function is protection, regulation of body temperature. The integumentary system also supports sensory receptors that send information to the nervous system. Organ Systems The skeletal system consists of the bones, ligaments, and cartilage. It provides protection and support and produces red blood cells. It also stores chemical salts. Organ Systems The muscular system produces movement, helps to maintain posture and produces heat. Organ Systems The nervous system consists of the brain, spinal cord, and receptors. It receive sensory information detects changes and in response, stimulates muscles and glands. Organ Systems The endocrine system is a series of glands that secrete hormones. The endocrine system contains many feedback systems to help maintain homeostasis. The glands include: • • • • • • • • • • Pituitary Thyroid Parathyroid Adrenal Pancreas Ovaries Testes Pineal gland Thymus Hypothalamus Organ Systems The cardiovascular system includes the heart, arteries, capillaries and veins. The function of the cardiovascular system is to transport blood. Organ Systems The lymphatic system includes the lymph vessels, lymph nodes, thymus and spleen. Organ Systems The function of the lymphatic system is to return tissue to blood as well as transport some absorbed food molecules and defend against infection. Organ Systems The respiratory consists of the nasal cavity, lungs, pharynx, larynx, trachea, and bronchi. Function include gas exchange between the external environment and an organism's circulatory system Organ Systems The digestive system includes: – Mouth – Tongue – Teeth – Salivary glands – Pharynx – Esophagus – Liver – Gallbladder – Pancreas – Intestines Organ Systems The function of the digestive system is to receive, break-down, and absorb food. It also eliminates wastes. Organ Systems The urinary system includes the: – Kidneys – Ureters – Urinary bladder – Urethra Organ Systems The function of the urinary system is to remove wastes, maintain water and electrolyte balance, and store and transport urine. Organ Systems The male reproductive system includes: • Scrotum • Testes • Epididymes • Vasa deferentia • Seminal vesicles • Prostate • Bulbourethral glands • Urethra • Penis Organ Systems The female reproductive system includes: • Ovaries • Uterine tubes • Uterus • Vagina • Clitoris • Vulva • The chief function of the reproductive system is to ensure survival of the species BODY DIVISIONS AND CAVITIES ORGANIZATION OF THE HUMAN BODY AXIAL PORTION • Head • Neck • Trunk APPENDICULAR PORTION • Arms • Legs Body Cavities • There are 2 main cavities in the body that are divided into sub cavities. • The ventral cavity is subdivided into the thoracic and abdominopelvic cavities. • The dorsal cavity is subdivided into the cranial cavity and the spinal canal. • The thoracic and abdominopelvic cavities are separated by the diaphragm. • The cranial cavity contains the brain. • The spinal canal contains the spinal cord. Body Cavities • Axial – Dorsal cavity • Cranial cavity (brain) • Vertebral canal (spinal cord) – Ventral cavity • Thoracic (lungs and mediastinum) – Mediastinum (area separating right and left containing heart, esophagus, trachea, thymus gland) • Abdominopelvic – Stomach, liver, spleen, urinary bladder, intestines (abdominal portion) – Large intestine, urinary bladder, reproductive organs. • Besides the large cavities, there are some smaller cavities in the body. • Smaller Body Cavities • Oral (teeth, tongue) • Nasal (sinuses) • Orbital (eyes and associated muscles, nerves) • Middle ear (middle ear bones) Homeostasis What is Homeostasis ? • Maintain the relative constancy of the internal environment of the cell as well as the human body despite external environmental changes • Body cells work best if they have the correct – Temperature – Water levels – Glucose concentration • Your body has mechanisms to keep the cells in a constant environment Examples of Homeostasis • Body Temperature • Water Balance • Chemistry Balance of Blood • Homeostasis is continually being disrupted by – External stimuli • heat, cold, lack of oxygen, pathogens, toxins – Internal stimuli • Body temperature • Blood pressure • Concentration of water, glucose, salts, oxygen, etc. • Physical and psychological distresses • Disruptions can be mild to severe • If homeostasis is not maintained, death may result To maintain the homeostasis our body has feed back systems Feedback System • A feedback system must have 3 parts: 1. Something to sense the environment—a sensor or the receptor 2. Analyzes the input, determines the appropriate response – a control center / integrator 3. A response mechanism that responds to the control center – a effector • The pathway carrying information from the receptor to the control center named as afferent pathway • The pathway which carrying the command of response from the control center to the effector named as efferent pathway • The feedback system can produce 2 types of responses: • It can have an opposite response to the stimulus. • OR • It can have the same kind of response as the stimulus. • The 2 types of responses are known as: 1. Negative feedback 2. Positive feedback Negative Feedback • Negative feedback is when the response is opposite to the stimulus and original stimulus is reversed • Most feed back systems in the body are negative feed back systems • Eg: Controlling of body temperature Positive Feedback • Positive feedback is where the response is the same as the stimulus. • In positive feedback the response can be magnified. • Eg: Pain during child birth Main systems involve in maintenance of Homeostasis • Nervous system – Controls and coordinates bodily activities that require rapid responses – Detects and initiates reactions to changes in external environment • Endocrine system – Secreting glands of endocrine regulate activities that require duration rather than speed – Controls concentration of nutrients and, by adjusting kidney function, controls internal environment’s volume and electrolyte composition Activity • Group activity – Presentation on Control of human body temperature