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GRADUATE SCHOOL OF PHARMACEUTICAL SCIENCES FACULTY OF PHARMACEUTICAL SCIENCES CONTENTS 1. HISTORY ................................................................................................................................................................................ 171 2. STUDY PROGRAM FOR UNDERGRADUATES .............................................................................................................. 171 3. COURSES FOR UNDERGRADUATES IN THE PHARMACEUTICAL SCIENCES.................................................... 171 Lectures 1. Required Subjects 2. Elective Required Subjects 3. Elective Subjects Laboratory Practice 1. Elemental Laboratory Practice 2. Special Laboratory Practice 4. STUDY PROGRAM FOR GRADUATE STUDENTS......................................................................................................... 173 5. FIELDS OF RESEARCH, INSTRUCTION AND STAFF OF THE DEPARTMENTS .................................................... 173 1. DIVISION OF PHYSICAL AND ORGANIC CHEMISTRY .......................................................................................... 173 Department of Bioorganic Medicinal Chemistry Department of Synthetic Medicinal Chemistry Department of Organic Chemistry Department of Pharmacognosy Department of Analytical Chemistry Department of Structural Biology Department of Genomic Drug Discovery Department of Biosurface Chemistry Department of Fine Organic Synthesis 2. DIVISION OF LIFE SCIENCES ..................................................................................................................................... 175 Department of Biological Chemistry Department of Molecular Microbiology Department of Molecular Pharmacology Department of Genetic Biochemistry Department of Physiological Chemistry Department of Biofunctional Chemistry 3. DIVISION OF PHARMACY AND BIOMEDICINAL SCIENCES ................................................................................ 176 Department of Drug Delivery Research Department of Pharmacology Department of Clinical Pharmacy and Education Deprtment of Patho-Functional Bioanalysis Department of Biopharmaceutics and Drug Metabolism Department of Clinical Pharmacy 4. DIVISION OF BIOINFORMATICS AND CHEMICAL GENOMICS............................................................................ 178 Department of Pharmacogenomics Department of Chemogenomics Department of Systems Biology Department of System Chemotherapy Department of Integrated Genomics Department of Computational Genomics 5. CONTRIBUTED CHAIRS .............................................................................................................................................. 180 Department of Neuroscience for Drug Discovery Department of Nanobio Drug Discovery Department of Systems Bioscience for Drug Discovery 6. EDUCATION AND RESEARCH FACILITIES .............................................................................................................. 181 Center for Integrative Education of Pharmacy Frontier Experimental Station for Medical Plant Research Center for Organic Elemental Microanalysis Support Program for Improving Graduate School Education Service Innovation Program 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 171 GRADUATE SCHOOL OF PHARMACEUTICAL SCIENCES FACULTY OF PHARMACEUTICAL SCIENCES Dean: ITOH, Nobuyuki, D.Pharm.Sci. 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501 Tel. +81-75-753-4510 Fax. +81-75-753-4502 http://www.pharm.kyoto-u.ac.jp/ 1. HISTORY The Faculty of Pharmaceutical Sciences originated in the Division of Pharmacy which was established in 1939 in the Faculty of Medicine. The Division of Pharmacy was expanded gradually and separated in 1960 from the Faculty of Medicine to establish the new Faculty of Pharmaceutical Sciences, with seven departments. Subsequently, the Faculty has been expanded from time to time, and is now comprised of twenty-seven Departments and three affiliated Institutions (the Center for Organic Elemental Microanalysis, Center for Integrative Education of Pharmacy Frontier and the Experimental Station for Medical Plant Research). A comprehensive reorganization of the Faculty of Pharmaceutical Sciences and the Graduate School of Pharmaceutical Sciences was completed in 1997. This reorganization is aimed to cope with the need for advanced research and education in pharmaceutical science and to emphasize both education and research in the Graduate School Program. The Graduate School is presently composed of four major fields of pharmaceutical sciences: 1. Division of Physical and Organic Chemistry; 2. Division of Life Sciences; 3. Division of Pharmacy and Biomedicinal Sciences , 4. Division of Bioinformatics and Chemical Genomics which has been established in 2007. The teaching and research activities of the Faculty and the Graduate School range over all the main fields of pharmaceutical sciences. The academic staff of the Graduate School is composed of sixty-three highly experienced professional scientists, including twenty Professors, twenty-five Associate Professors and Lecturers, and fourteen Assistant Professors. All members of the Graduate Program are now jointly appointed as the teaching staff for the undergraduate courses. The Faculty and the Graduate School also have a division for administrative tasks. The Graduate School has the following facilities: library, laboratories for NMR, MS, ESR, CD, Laser-Raman, X-ray, electron-microscope, radioisotope, biotechnology, molecular biology and cell biology, a greenhouse, and botanical garden. 2. STUDY PROGRAM FOR UNDERGRADUATES The Faculty offers instruction for undergraduate students of the Division of Pharmacy and Division of Sciences for Drug Discovery. Thirty and fifty undergraduate students are admitted for these divisions, respectively, each year. To qualify for admission, students must have completed 12 years of schooling, and pass the entrance examination, which is usually given towards the end of February or at the beginning of March. Foreign students must take a General Examination for Overseas Students, and also the Faculty's special entrance examination for overseas students which is usually given at the end of February. See the section entitled "Academic Programs" in Part 1 of the Bulletin for general regulations and rules concerning admission. To complete the undergraduate course and to receive the bachelor's degree, students are required to study for at least six years in the Division of Pharmacy or four years in the Division of Sciences for Drug Discovery. The Bachelor of Pharmacy and Bachelor of Sciences for Drug Discovery degrees are conferred upon those students who have satisfied all the credits requirements and have also completed the Graduation Research Project (Specialized Laboratory Work), under the supervision of an academic member of the Graduate School of Pharmaceutical Sciences corresponding to the student's specialization. For further details, consult the Kyoto University Regulations, and the Rules of the Faculty of Pharmaceutical Sciences. The minimum numbers of courses and credits required for graduation are as follows: Courses in Liberal Arts and Sciences: 62 credits minimum, including 1. Humanities and Social Sciences: 20 credits in 5 courses (elective subjects) 2. Natural Sciences: 26 credits in 15 courses (elective and specified subjects) 3. Foreign Languages: 2 languages; 8 credits in English and 4 credits in one other selected from German, French, Chinese, Russian, Italian, Korean, and Spanish. Courses in the Division of Pharmacy: 138 credits minimum, including 1. Lecture subjects: 82 credits 2. Laboratory practice: 16 credits 3. Clinical practice: 22 credits 4. Specialized laboratory work: 12 credits Courses in the Division of Sciences for Drug Discovery: 80 credits minimum, including 1. Lecture subjects: 56 credits 2. Laboratory practice: 18 credits 3. Specialized laboratory work: 6 credits 3. COURSES FOR UNDERGRADUATES IN THE PHARMACEUTICAL SCIENCES Classification of Subjects Lectures 1. Required Subjects (2 credits each) Course (Lecturer) Introduction to Pharmaceutical Sciences and Ethics by staff Fundamental Biology for Pharmaceutical Sciences by Takeshima Fundamental Physical Chemistry for Pharmaceutical Sciences by Handa Basic Organic Chemistry A by Ohno Basic Organic Chemistry B by Takasu Scientific English by Foong 172 Organic Chemistry 1(Synthetic Organic Chemistry) by Kawabata Organic Chemistry 2(Bioorganic Chemistry) by Takemoto Organic Chemistry 3(Medicinal Chemistry) by Fujii, Kakeya, Futaki, Hattori Organic Chemistry 4(Fine Synthetic Chemistry) by Tomioka, Yamada Pharmacognosy 2(Pharmaceutical Resources) by Kakeya, Hattori Physical Chemistry 1(Quantum Chemistry) by Kitaura Physical Chemistry 2(Electro- and Interface- Chemistry) by Handa Analytical Chemistry 1(Basic Analytical Chemistry) by Matsuzaki Analytical Chemistry 2(Radiochemistry) by Saji Analytical Chemistry 3(Spectroscopy) by Hoshino,Nakano Biological Chemistry 1(Biomolecules) by Yamazaki Biological Chemistry 2(Energy Metabolism) by Nakayama Biological Chemistry 3(Molecular Biology) by Itoh Microbiology 1(Bacteriorogy) by Tochikura Pharmaceutical Health Science 1(Health Chemistry) by Nakayama Physiology 2(Molecular Physiology) by Kaneko Physiology 3(Pathophysiology for drug discovery and personalized medicine) by Tsujimoto,Okamura Pharmacology 1(Overview and Peripheral Nervous System Pharmacology) by Akaike,Kume Pharmaceutics 1(Liquid Formulations) by Hashida,Yamashita Medicinal Pharmacy 3(Biopharmaceutics) by Takakura,Yamaoka 2. Elective Required Subjects [2 credits each] Course (Lecturer) Pharmaceutical Botany by Ito Information Processing Basics by Nakatsu,Hirasawa 3. Elective Subjects (2 credits each) Course (Lecturer) Organic Chemistry 5(Biofunctional Chemistry) by Futaki Pharmacognogy 1(Natural Product Chemistry) by Tomioka,Yamada Pharmacognosy 3(Applied Pharmacognosy) by Ito Medicinal Chemistry Discovery and Development of New Drugs by Fujii, Kitaura, Sugimoto Organic Chemistry Exercise by staff Physical Chemistry 3(Structural Chemistry) by Kato Physical Chemistry 4(Biophysical Chemistry) by Matsuzaki,Hoshino Analytical Chemistry 4(Clinical Chemistry) by Saji,Ono Medicinal Physical Chemistry Exercise 1 by staff Medicinal Physical Chemistry Exercise 2 by staff Biological Chemistry 4(Applied Molecular Biology) by Itoh Biological Chemistry 5(Cell Biology) by Kozutsumi Biological Chemistry 6(Physiological Chemistry) by Negishi Biological Chemistry 7(Immunobiology) by Sugimoto Microbiology 2(Virology) by Watanabe Pharmaceutical Health Science 2(Public Health) by Nakayama Physiology 1(Anatomical Physiology) by Akaike,Kaneko Physiology 4(Genomic medicine) by Tsujimoto,Okamura Pharmacology 2(Cardiovascular Pharmacology) by Nakagawa Pharmacology 3(Central Nervous System Pharmacology) by Akaike,Kume Therapeutic Pharmacology 1 by Kaneko,Nakagawa Therapeutic Pharmacology 2 by Akaike,Kume Pharmaceutics 2(Solid formulations) by Hashida,Nishikawa Clinical Pharmacy 1 by Yano, Katsura Clinical Pharmacy 2 by Yano Pharmacopoeia ; Pharmaceutical Laws by Hashida,Yamashita Statistical Basis for Biosciences by Yano Introduction to Bioinformatics by Okuno,Kaneko Pharmaceutical R&D by Sakaeda,Okuno Laboratory Practice 1. Elemental Laboratory Practice (required subject, a total of 16 credits) Course Part I: Advanced Laboratory Practice in Pharmaceutical Sciences I (4 credits) Part II: Advanced Laboratory Practice in Pharmaceutical Sciences II (4 credits) Part III: Advanced Laboratory Practice in Pharmaceutical Sciences III (4 credits) Part IV: Advanced Laboratory Practice in Pharmaceutical Sciences IV (4 credits) 2. Special Clinical Practice (required subject, a total of 22 credits for Division of Pharmacy) Course Pre-Training for Clinical Clerkship Clinical Clerkship in Hospital Pharmacy Clinical Clerkship in Community Pharmacy 3. Special Laboratory Practice (Graduation Research Project ) (elective subject, 6 or 12 credits each) Course (Lecturer) Bioorganic Medicinal Chemistry by Fujii,Ohno Synthetic Medicinal Chemistry by Tomioka, Yamada Organic Chemistry by Takemoto,Takasu Pharmacognosy by Ito Analytical Chemistry by Matsuzaki, Hoshino Structural Biology by Kato,Nakatsu Biosurface Chemistry by Handa,Nakano Biological Chemistry by Takeshima,Yamazaki Molecular Microbiology by Watanabe Molecular Pharmacology by Kaneko, Nakagawa Genetic Biochemistry by Itoh Physiological Chemistry by Nakayama, Sugimoto Drug Delivery Research by Hashida, Yamashita Pharmacology by Akaike,Kume, Patho-Functional Bioanalysis by Saji,Ono Biopharmaceutics and Drug Metabolism by Takakura, Yamaoka, Nishikawa Phamacogenomics by Tsujimoto,Hirasawa Chemogenomics by Fujii, Systems Biology by Okamura System Chemotherapy and Molecular Sciences by Kakeya, Hattori System Chemotherapy (Computational Drug Design) bu KitauraFine Organic Synthesis by Kawabata Biofunctional Chemistry by Futaki Clinical Pharmacy by Inui Integrated Genomics by Kanehisa Computational Genomics by Mamitsuka Experimental Station for Medicinal Plants by Staff Pharmaceutical Sciences 173 4. STUDY PROGRAM FOR GRADUATE STUDENTS The comprehensive structural reorganization of the entire Graduate School of Pharmaceutical Sciences was completed in 1997. The Graduate School, which is known as the Graduate School of Pharmaceutical Sciences, offers courses for advanced instruction and opportunity for research; the staff includes all the members of the Graduate School, the staff of the four Departments of the Institute for Chemical Research, the staff of the Pharmaceutical Division of the University Hospital, and of the Institute for Virus Research. The Graduate School provides four courses: 1. Physical and Organic Chemistry, 2. Life Sciences, 3. Pharmacy and Biomedicinal Sciences, and 4. Bioinformatics and Chemical Genomics (from 1st April, 2007). A limited number (temporally maximum five) of Master course students can be admitted to the advanced clinical pharmacy course (beginning from 2001). A total of eighty graduate students are admitted each year into the Graduate School. To qualify for admission, applicants must normally have completed 4 years of education at the undergraduate school and also pass the entrance examination, usually given in August. Overseas students wishing to take the Graduate course must pass the same entrance examination as that given to Japanese students, or the Faculty's special entrance examination for overseas students usually given in December or January. The Graduate School offers the Master's and Doctoral degrees. To receive the Master's degree, students are required to study for at least two years, and to earn a minimum of 30 credits in the graduate courses, including at least 14 credits in required subjects and at least 16 credits in elective subjects. The students who were admitted to advanced clinical pharmacy course and qualified as a licensed pharmacist must have 6 months practice at University hospital. Students must submit a Master's thesis and pass the final examinations, including an oral presentation. To receive the Doctoral degree, students must normally conduct research work for at least three years in the specialized field under the supervisor's guidance, and to earn a minimum of 8 credits in the graduate courses, submit a Doctoral thesis and pass the final examinations, including an oral presentation. 5. FIELDS OF RESEARCH, INSTRUCTION AND STAFF OF THE DEPARTMENTS 1. DIVISION OF PHYSICAL AND ORGANIC CHEMISTRY Department of Bioorganic Medicinal Chemistry Professor FUJII, Nobutaka, D.Pharm.Sci. (Kyoto Univ.) Associate Professor OHNO, Hiroaki, D.Pharm.Sci. (Kyoto Univ.) Assistant Professor OISHI, Shinya, D.Pharm.Sci. (Kyoto Univ.) Outline of Teaching Activities The Laboratory is responsible for undergraduate instruction in organic chemistry (chemical bonding, stereochemistry, and modern synthesis) and medicinal chemistry (design and synthesis). The Department provides graduate students with seminars, which review and discuss recent important medici- nal and synthetic chemical literature. Laboratory practice in synthetic chemistry, heteroaromatic chemistry and medicinal chemistry is also provided. Outline of Research Activities The main research fields are as follows: 1. Development of efficient strategy for synthesis of heterocycles directed toward construction of novel drug templates 2. Synthetic studies on direct construction of natural product type drug like templates 3. Synthetic studies on peptides, including antimicrobial and anti-viral peptides 4. Synthetic studies on peptidomimetics, including conformationally constrained pseudopeptides Department of Synthetic Medicinal Chemistry http://www.pharm.kyoto-u.ac.jp/tomioka/index.html Professor TOMIOKA, Kiyoshi, D.Pharm.Sci. (Univ. of Tokyo) Associate Professor YAMADA, Ken-ich, D.Pharm.Sci. (Univ.of Tokyo) Assistant Professor YAMAMOTO, Yasutomo, M.Pharm.Sci. (Kyoto Univ.) Outline of Teaching Activities The Department is responsible for general instruction in synthetic organic chemistry (molecular structure, stereochemistry, synthesis, mechanism, design, total synthesis and biological activity-structure relationships) for undergraduate students, and for laboratory practice on advanced high grade synthetic organic chemistry. Outline of Research Activities 1. Synthetic methodology 2. Asymmetric reaction 3. Synthesis and chemistry of biologically active molecule 4. Molecular basis for bioresponse molecule 5. Molecular architecture Department of Organic Chemistry Professor TAKEMOTO, Yoshiji, D.Pharm.Sci. (Osaka Univ.) Associate Professor TAKASU, Kiyosei, D.Pharm.Sci. (Kyoto Univ.) Outline of Teaching Activities The Laboratory is responsible for instruction in organic chemistry covering the basic concepts of organic reactions, stereochemistry, synthesis, and spectroscopic methods for undergraduate students. The Department provides graduate students with seminars which review and discuss recent important organic and organometallic reactions. Laboratory practice in advanced synthetic and organometallic chemistry is also provided. Outline of Research Activities 1. Development of new enantio- and stereoselective synthetic methods involving transition-metal catalysts 2. Development of environmentally friendly synthetic methods for process chemistry 174 3. Total synthesis of biologically important synthetic and natural products 4. Synthetic studies on multi-functional heterocyclic compounds and their use as drug-templates 5. Development of new biological and medicinal probes based on chemical biology Department of Pharmacognosy Associate Professor ITO, Michiho, D.Pharm.Sci. (Kyoto Univ.) Outline of Teaching Activities The Department is responsible for undergraduate instruction in pharmacognosy covering characteristics, production, biological activity and evaluation of medicinal plants and natural medicines. For graduate students, the Department provides seminars, reviews and discussion of recent pharmacognostical and botanical literature. Outline of Research Activities Main research fields are as follows: 1. Genetic regulation of secondary metabolism and production of medicinal compounds in plants 2. Molecular basis of secondary metabolism in medicinal plants 3. Phytochemical and pharmacological analyses of traditional medicines 4. Field research of important medicinal resources and traditional medicines in Asian countries Department of Analytical Chemistry http://www.pharm.kyoto-u.ac.jp/yakkai/ Professor MATSUZAKI, Katsumi, D.Pharm.Sci. (Kyoto Univ.) Associate Professor HOSHINO, Masaru, D.Sci. (Osaka Univ.) Assistant Professor YANO, Yoshiaki, D.Pharm.Sci. (Kyoto Univ.) Outline of Teaching Activities This Department is responsible for general undergraduate instruction in analytical chemistry and in biophysical chemistry necessary for the understanding of the structure formation and function of biomembranes and proteins. The Department provides graduate students with seminars, which introduce the latest advances in membrane and protein biophysics. Outline of Research Activities The main research fields are as follows: 1. Elucidation of action mechanisms of antimicrobial peptides and the development of potent antibiotic peptides 2. Thermodynamics of transmembrane helix-lipid interactions 3. Interactions of amyloid peptides with glycolipids 4. Regulation of G-protein coupled receptors 5. Structure determination of proteins by NMR Department of Structural Biology Professor KATO, Hiroaki, D.Agr. (Kyoto Univ.) Associate Professor NAKATSU, Toru, D.Agr. (Kyoto Univ.) Assistant Professor YAMAGUCHI, Tomohiro, D.Sci. (Kyoto Univ.) Outline of Teaching Activities This Department is responsible for general undergraduate instruction in structural sciences including quantum chemistry, physical chemistry of materials, and X-ray crystallography as well as their application to understanding of biological function. For graduate students, the department provides classes in advanced structural sciences, seminars, reviews and discussions on recent publications in structural biology. Outline of Research Activities The emphasis of the research is on understanding the structure and function of macromolecules through structure determination by X-ray crystallography as well as a wide range of correlative biophysical and biochemical studies of function. The main research fields are as follows: 1. Structural-basis for action of transporters and channels 2. Structural and functional studies on translocation machinery of membrane proteins to organelles 3. Structural origin of catalytic power of enzymes 4. Structural biology of circadian clock machinery Department of Genomic Drug Discovery Outline of Teaching Activities The Department is responsible for undergraduate instruction in Drug Discovery Process based on Genome Science. The Department provides graduate students with seminars, which review and discuss recent important literature in molecular biology and genome science. Outline of Research Activities The main research fields are as follows: 1. Discovery of novel drug target and its validation by integrative genome science 2. Functional genomic study using transgenic/knockout animals Department of Biosurface Chemistry Professor HANDA, Tetsurou, D.Pharm. Sci. (Kyoto Univ.) Associate Professor NAKANO, Minoru, D.Eng. (Kyoto Univ.) Outline of Teaching Activities The department is responsible for undergraduate instruction in thermodynamics, solution chemistry, electrochemistry, phase equilibrium, chemical reaction, and colloid and surface chemistry. There is a seminar which reviews recent progress in biosurface and biophysical chemistry. Laboratory practice on advanced biocolloid and biosurface chemistry is also provided. Outline of Research Activities 1. Biophysical chemistry on the plasma apolipoprotein recognition of lipid surface in lipoprotein metabolism 2. Biocolloid and biosurface chemistry on assembling Pharmaceutical Sciences 175 phospholipids, sphingolipids, glycolipids and glycerides into monolayers (emulsions), bilayers (vesicles) and nonbilayer structures (cubosomes, hexosomes) 3. Biophysical aspects of lipid risk factors for atherosclerosis 4. A drug design of inhibitors for protein tyrosine kinases Department of Fine Organic Synthesis Professor KAWABATA, Takeo, D.Pharm. Sci. (Kyoto Univ.) Associate Professor FURUTA,Takumi, D.Pharm. Sci. (Kyoto Univ.) Assistant Professor YOSHIMURA, Tomoyuki, D.Pharm. Sci. (Tokushima Univ.) Outline of Teaching Activities This Department is responsible for instruction of basic techniques in synthetic organic chemistry and molecular recognition. These include separation, purification, and characterization of organic molecules and instrumental analyses such as NMR, IR, UV, MS, CD and so on. Recent papers dealing with unit reactions, asymmetric syntheses, molecular recognition, and total synthesis of biologically active natural products are the main topics of discussion in the group seminar. Outline of Research Activities Research in this laboratory focuses on molecular chirality. Programs are active in the areas of asymmetric synthesis based on“memory of chirality”, organocatalysis for selective reactions, synthesis of novel nitrogen heterocycles, total synthesis of biologically active products, visualization of molecular information by functional phenolphthaleins, and the structural and functional investigation of D,L-oligoesters, D,L-oligopeptides, and homochiral oligonaphthalenes. 2. DIVISION OF LIFE SCIENCES Department of Biological Chemistry http://bio.pharm.kyoto-u.ac.jp/biochem/index.html Professor TAKESHIMA, Hiroshi, D.Pharm.Sci. (Kyoto Univ.) Associate Professor YAMAZAKI, Tetsuo, D.Med. (Chiba Univ.) Outline of Teaching Activities This Department is responsible for instruction in biochemistry, molecular biology, cell biology and immunology for undergraduate and graduate students. The Department provides graduate students with seminars, which review and discuss recent advances in biochemistry and molecular biology. Laboratory practice in advanced experimental techniques of molecular biology and cellular physiology is also provided. Outline of Research Activities The current research activities are as follows: 1. Structure and function of intracellular Ca2+ stores 2. Mechanism of cellular Ca2+ signaling 3. Molecular determinants of muscle membrane structures 4. Biological roles of sugar chains Department of Molecular Microbiology Associate Professor WATANABE, Yoshihiko, Ph.D. (D.Med.Sc. Kyoto Univ.) Teaching Activities Two subjects, Microbiology 1and 2, are covered in lectures for 3rd -year undergraduate students , which are composed of lectures focusing respectively on bacteria and viruses (morphology, physiology, and molecular biology) to provide fundamental knowledge and understanding of microbes that cause infectious diseases, including pathogenesis, host defense mechanisms, prophylaxis, and chemotherapy. The Laboratory Practice of Microbiology assigned to 3rd-year undergraduate students is a training course on fundamental techniques required for research in microbiology. Special Laboratory Practice in Molecular Microbiology assigned to 4th-year students includes research and seminars concerning molecular and cellular biology and immunology of host defense mechanisms against animal infectious viruses and tumors. Research Activities The research interests of the department include basic molecular and cellular biology, virology, immunology, and oncology. The current subjects chosen for study are as follows: 1. Molecular mechanisms of interferon production in various phases of host defense 2. Cellular responses to interferon action in immune reaction, tumor development and viral infection 3. Basic therapeutic studies for interferon gene therapy against infectious diseases and cancers Department of Molecular Pharmacology Professor KANEKO, Shuji, D.Pharm.Sci. (Kyoto Univ.) Associate Professor NAKAGAWA, Takayuki, D.Pharm.Sci. (Kyoto Univ.) Assistant Professor SHIRAKAWA, Hisashi, D.Pharm.Sci. (Kyoto Univ.) Outline of Teaching Activities The department provides instructuon and techniques in general physiology, anatomical and functional bases of the living body, neuropharmacology and relevant subfields of pharmacology through lectures, laboratory practice and seminars for both undergraduate and graduate students. We also provide a unique ’Life Science Dictionary’ for students and researchers on the World Wide Web http://lsd.pharm.kyoto-u.ac.jp Outline of Research Activities The main research fields are as follows: 1. New drug development targeted for various membranetransport proteins on the basis of genomic information 2. Development of new screening strategies and probes for ion channel study 3. Physiological and pathological roles of membrane-transport proteins expressed in neurons and glia 4. Neuropharmacology of analgesics and molecular biology of pain 176 5. Molecular mechanisms of drug tolerance and dependence prostaglandin receptors Department of Genetic Biochemistry Professor ITOH, Nobuyuki, D.Pharm.Sci. (Kyoto Univ.) Department of Biofunctional Chemistry Professor FUTAKI, Shiroh, D.Pharm.Sci. (Kyoto Univ.) Lecturer MIYAKE, Ayumi, D.Pharm.Sci.(Kyoto Univ.) Assistant Professors IMANISHI, Miki, D.Pharm.Sci. (Kyoto Univ.) Assistant Professor KONISHI, Morichika, D.Pharm.Sci. (Kyoto Univ.) NAKASE, Ikuhiko, D.Pharm.Sci. (Kyoto Univ.) Outline of Teaching Activities The Department is responsible for undergraduate instruction in biochemistry (structure and function of nucleic acid, mechanism of protein synthesis, and mechanism and regulation of gene expression), and in applied molecular genetics (recombinant DNA technology, biotechnology and molecular biology of diseases). The graduate seminar reviews and discusses recent literature on biochemistry, molecular biology and biotechnology. Outline of Research Activities The main research fields are as follows: 1. Identification of genes for novel intercellular signaling molecules (growth factors, differentiation factors and hormones) 2. Structure and function of signaling molecules, and regulation of their gene expression 3. Roles of signaling molecules in metabolic regulation 4. Roles of signaling molecules in vertebrate development Department of Physiological Chemistry Professor NAKAYAMA, Kazuhisa, Ph.D.(Kyoto Univ.) Outline of Teaching Activities The Department is responsible for undergraduate instruction in bioorganic, bioinorganic, and biomedical chemistries, and also provides graduate students with seminars which review and discuss recent biochemical and biomedical literature. In addition, the Department provides laboratory practice in biochemical, biophysical, and molecular biological chemistries. Outline of Research Activities The ultimate goal of our research is the regulation of cellular functions by designed peptides and proteins. Current projects include “Development of membrane permeable peptide vectors”, “Creation of novel zinc finger peptides with desired DNA binding characteristics”, and “Design of functional peptides responsive to external signals”. This Department, which belongs to the Institute for Chemical Research of Kyoto University, is affiliated with the Graduate School of Pharmaceutical Sciences. 3. DIVISION OF PHARMACY AND BIOMEDICINAL SCIENCES Associate Professor SUGIMOTO, Yukihiko, D.Pharm.Sci. (Kyoto Univ.) Department of Drug Delivery Research http://dds.pharm.kyoto-u.ac.jp/Dds-Home/index.htm Professor HASHIDA, Mitsuru, D.Pharm.Sci. (Kyoto Univ.) Assistant Professor SHIN, Hye-Won, D. Phil. (Univ.Tsukuba) Associate Professor YAMASHITA, Fumiyoshi, D.Pharm.Sci. (Kyoto Univ.) Outline of Teaching Activities The laboratory is responsible for general undergraduate instruction in physiological chemistry (generation and storage of metabolic energy, carbohydrate metabolism and fatty acid metabolism, hormonal regulation of metabolism), and in environmental health and hygiene chemistry. The department provides graduate students with seminars, which review and discuss recent important biochemical and physiological literature, focused on cell biology, membrane traffic, signal transduction, and inflammation. Laboratory practice in cell biology, molecular biology and physiology is also provided. Outline of Research Activities The main research fields are as follows: 1. Molecular mechanisms underlying membrane trafficking and localization of proteins around the Golgi apparatus 2. Relationship between membrane traffic and other cellular functions, including protein degradation and cell division 3. Molecular biological studies on the biology of mast cells and other inflammation-participating cells 4. Molecular biological studies on structure and function of Assistant Professor KAWAKAMI, Shigeru, D.Pharm.Sci. (Kyoto Univ.) Outline of Teaching Activities Lectures for undergraduate students deal with the general principles of the formulation, evaluation, and technology of various dosage forms and introduction to biopharmaceutics and pharmacokinetics. Advanced biopharmaceutical experimentation and theories concerning the mechanism of drug disposition in the body are provided for graduate students, with particular emphasis upon the control of the in vivo fate of drugs and delivery systems. In seminars students participate in discussion and review of literature in the targeting and controlled release of drugs involving peptides, proteins, and genes. Outline of Research Activities The main emphasis of the Department is on the development of methods of controlled drug delivery such as: 1. Hepatic targeting employing receptor-mediated endocytosis 2. Rational design of macromolecular and particulate carriers Pharmaceutical Sciences 177 3. In vivo disposition control and targeting of proteins by chemical modification 4. Cell specific delivery of genes 5. In silico prediction of mucosal and skin absorption of drugs Department of Pharmacology Professor AKAIKE, Akinori, D.Pharm.Sci. (Kyoto Univ.) Associate Professor KUME, Toshiaki, D.Pharm.Sci. (Kyoto Univ.) Assistant Professor IZUMI, Yasuhiko, D.Pharm.Sci. (Kyoto Univ.) Outline of Teaching Activities The laboratory is responsible for undergraduate instruction in general physiology and pharmacology including general principles of drug action, receptors and ion channels, pharmacological actions of drugs acting on the peripheral and central nervous systems. The department provides graduate students with advanced lectures on mechanisms of actions of drugs and laboratory practice in advanced methods in pharmacology, including primary culture of neurons, purification of biologically active substances and behavioral pharmacology. In seminars, reviews and discussions of recent important pharmacological literature are provided. Outline of Research Activities The main research fields are as follows: 1. Elucidation of mechanism of neuroprotective action of serofendic acid, a novel low molecular weight substance derived from fetal calf serum 2. Mechanisms of neuroprotective effects of nicotinic acetylcholine, neuropeptides, steroids and vitamins 3. Analysis of the role of nitric oxide and reactive oxygen species in the neurodegeneration of the brain and retina 4. Basic research for development of novel drugs on acute and chronic neurodegenerative disorders Department of Clinical Pharmacy and Education Associate Professor YANO, Ikuko, D.Pharm.Sci. (Kyoto Univ.) Outline of Teaching Activities The Department is responsible for general instruction and practice in clinical pharmacy and pharmacist activities for undergraduate and graduated students, and for laboratory practice on pharmacokinetics / pharmacodynamics. Outline of Research Activities 1.Pharmacokinetics and pharmacodynamics in disease states 2.Therapeutic drug monitoring and individualized pharmacotherapy Deprtment of Patho-Functional Bioanalysis Professor SAJI, Hideo, D.Pharm.Sci. (Kyoto Univ.) Associate Professor ONO, Masahiro, D.Pharm.Sci. (Kyoto Univ.) Assistant Professors TEMMA, Takashi, M.Pharm.Sci. (Kyoto Univ) KIMURA, Hiroyuki, D.Pharm.Sci. (Kyoto Univ.) Outline of Teaching Activities Responsible for the general undergraduate student instruction in radiochemistry (physical and chemical basis, principles on the production of radionuclides, detection of radioactivity, synthesis of labeled compounds and their application in life science), radiopharmaceutical chemistry (basis on diagnostic and therapeutic radiopharmaceutical drug design and synthesis), radiopharmacokinetic and radiopharmacodynamic aspects of localization mechanism and bioanalytical chemistry. Some basic concepts in radiation biology along with procedures for the safe handling of radioactive material are offered. Quantitative analysis of bioactive materials with non-radioactive methods is also offered, along with the application of radiolabeled compounds in nuclear medicine, a bioimaging field and in drug development research. Also, inroads made by other imaging technologies, such as conventional X-ray computed tomography (CT), ultrasound imaging (US) and nuclear magnetic resonance imaging (MRI), and basis on bioimaging assisted by the use of contrast agents are considered. For the graduate students, seminars are held for review and discussion of recent literature. Outline of Research Activities The department is currently focussing on the development of newly designed and molecular imaging probes radiopharmaceuticals for biology, in vivo biochemistry, medical diagnosis and therapy, using gamma, beta and positron emitting radionuclides. Moreover, the use of radiolabeled compounds for research in drug manufacturing and in vivo pharmacological or toxicological interaction of drugs, constitute another field of interest. The main nuclear bio-imaging technologies employed in the diagnosis of patients are the positron emission tomography (PET) and the single photon emission computed tomography (SPECT). In the area of therapeutical drugs, protein or peptide based radiopharmaceuticals, bone cells sensitive drugs are being studied for radiotherapy and pain palliation. Main areas of research: 1. Drug development for the bioimaging of brain neurotransmitters, neuroreceptor functions and enzymatic activity in physiological condition and diseases. Pharmacokinetic and pharmacodynamic evaluation of neuroleptic drug action in living animal models under diverse pharmacological medication 2. Drug development for tumor diagnosis and therapy based on radiometal labeled antitumor antibodies, peptides and on biologically active radiometal complexes;moreover, studies on the use of radiotherapeutic drugs in cancer and bone pain palliation 3. Drug development for the diagnosis of energy metabolism related disorders and hypoxic tissue related disorders (heart, brain ischemia) 4. Development of methodologies for the in vivo imaging for specific gene expression (molecular imaging) 5. Development of in vitro and in vivo dynamic methodologies for the pharmacokinetic and pharmacodynamic analysis of drug action 6. Studies on metals and metal-complexes in biological systems and their applicability as drugs for diagnostic or therapeutic 178 use Department of Biopharmaceutics and Drug Metabolism http://www.pharm.kyoto-u.ac.jp/byoyaku/English/index.html Professor TAKAKURA, Yoshinobu, D.Pharm Sci. (Kyoto Univ.) Associate Professors YAMAOKA, Kiyoshi, D.Pharm Sci. (Kyoto Univ.) NISHIKAWA, Makiya, D.Pharm.Sci. (Kyoto Univ.) Outline of Teaching Activities Lectures on basic biopharmaceutics and pharmacokinetics are provided by the Department for undergraduate students. Advanced in vivo and in vitro experimental methods and techniques and theories for mechanistic studies on drug disposition in the body are provided for graduate students. The Department also provides students with seminars, in which recent topics and advances in biopharmaceutical studies are reviewed and discussed based on the literature with particular emphasis on drug disposition. Outline of Research Activities The main research subjects in the Department are as follows: 1. Design and tissue distribution control of nucleic acid drugs for optimized gene therapy and DNA vaccination 2. Establishment of therapeutic strategies based on RNA interference using siRNA and shRNA-expressing vectors 3. Manipulation of immunological consequences by control of in vivo and intracellular pharmacokinetics of DNA vaccine and antigen peptide 4. Analysis of nucleic acid-mediated immune activation and its therapeutic application based on DNA assembly 5. Statistical pharmacokinetic analysis of tissue distribution of therapeutic macromolecular compounds Department of Clinical Pharmacy Professor INUI, Ken-ichi, D.Pharm.Sci. (Kyoto Univ.) Associate Professor KATSURA, Toshiya, D.Pharm.Sci. (Kyoto Univ.) Lecturer MASUDA, Satohiro, D.Pharm.Sci. (Kyoto Univ.) Assistant Professors MOTOHASHI, Hideyuki, D.Pharm.Sci. (Kyoto Univ.) FUKUDO, Masahide, D.Pharm.Sci. (Kyoto Univ.) YONEZAWA, Atsushi, D.Pharm.Sci. (Kyoto Univ.) Outline of Teaching Activities: The department is responsible for instruction of undergraduate and graduate students in the Schools of Medicine and Pharmaceutical Sciences, as well as clinical training of pharmacy residents, in efficacy and safety of drug therapy. Outline of Research Activities: 1. Functional and molecular characterization of drug trans- porters and its clinical application 2. Pathophysiological roles of drug transporters 3. Mechanisms of drug interaction 4. Pharmacogenomics and personalized medicine This Department, which belongs to Kyoto University Hospital, is affiliated with the Graduate School of Pharmaceutical Sciences 4. DIVISION OF BIOINFORMATICS AND CHEMICAL GENOMICS Department of Pharmacogenomics Professor TSUJIMOTO, Gozoh, M.D., Ph.D. (Shinshu Univ.) Associate Professor HIRASAWA, Akira, D.Med.Sci. (Yamanashi Univ.) Assistant Professor TERASAWA,Kazuya, D.Sci. (Kyoto Univ.) KIMURA,Ikuo, D.Pharm.Sci. (Kyoto Univ.) Outline of Teaching Activities The Department is responsible for undergraduate instruction in Pharmacogenomics based on Genome Science (Bioinformatics, Pharmacogenomics, Genome Technology, Transcriptome Scanning, Proteomics). The Department provides graduate students with seminars, which review and discuss recent important literature in molecular biology, genome science, bio-informatics, medicine and physiology. Outline of Research Activities The main research fields are as follows: 1. Personalized medicine (pharmacogenomics) based on gene variation 2. Ligand fishing of "orphan G-protein-coupled receptors" and structure-function analysis Department of Chemogenomics Professor FUJII, Nobutaka, D.Pharm.Sci. (Kyoto Univ.) Assistant Professor OISHI, Shinya, D.Pharm.Sci. (Kyoto Univ.) Outline of Teaching Activities The Laboratory is responsible for undergraduate instruction in chemical biology and bioorganic chemistry. The department provides graduate students with seminars, which review and discuss recent research on chemical biology and functional genomics/proteomics. Laboratory practice in chemical biology and chemical genomics are also provided. Outline of Research Activities The main research fields are as follows: 1. Functional studies on peptides/proteins, including anti-cancer and anti-viral peptides/proteins 2. Functional studies on peptidomimetics, targeting to chemokine receptors and GPR54 3. Chemical biology using specific chemical probes Pharmaceutical Sciences 179 Department of Systems Biology Professor OKAMURA, Hitoshi, D.Med (Kyoto Prefectural University of Medicine) dates utilizing both chemoinformatics and bioinformatics methods. Associate Professor DOI, Masao, D. Sci (Tokyo Univ) Department of System Chemotherapy (Computational Drug Design) Professor KITAURA, Kazuo, Ph.D. (Osaka City Univ.) Assistant Professor YAMAGUCHI, Yoshiaki, D. Bioscience (Kyoto Univ) Associate Professor MURATA, Katsumi, Ph.D. (Grad.Univ. Advanced Studies) Outline of Teaching Activities The Laboratory is responsible for undergraduate instruction of Human Physiology and Pathophysiology. The department provides graduate students with seminars, which review and discuss with their own themes including medical and pharmacological fields. Laboratory practice in biological sciences featuring circadian biology is also provided. Outline of Teaching Activities The Laboratory is responsible for undergraduate instruction in physical chemistry (quantum chemistry and theory of chemical bond and reaction). The Department provides graduate students with seminars, which review and discuss biomolecular simulation and structure based drug design. Laboratory practice in computational chemistry (electronic structure calculations and molecular dynamics simulations) is also provided. Outline of Research Activities How TIME is generated and tuned in the body? We will clarify the secret of generation and tuning of TIME in mammalian circadian system by multi-layered view at intracellular, intercellular and individual levels. TIME is transmitted in multilayer systems: 1) intracellular system of generation of cyclic TIME, 2) Intercellular system for synchronizing TIME, and 3) Symphony of TIME in individuals. Through clarifying this integration network mechanism of TIME, we will develop new drugs for tuning TIME. Department of System Chemotherapy and Molecular Sciences Professor KAKEYA, Hideaki, D. Engineer. (Keio Univ.) Associate Professor HATTORI, Akira, D. Pharm. Sci. (Gifu Pharm. Univ.) Outline of Teaching Activities The Laboratory is responsible for instruction in natural product chemistry, medicinal chemistry, and chemical biology for undergraduate students. The department provides graduate students with seminars, which review and discuss recent important natural product chemistry and chemical biology toward system chemotherapy. Laboratory practice in advanced natural product chemistry, medicinal chemistry and chemical biology is also provided. Outline of Research Activities The main research fields are as follows: 1. Advanced chemical biology research for establishing system chemotherapy in order to cure multi-factorial diseases; e.g. cancer, immunodeficiency, diabetes, cardiac diseases, and neuronal diseases. 2. Advanced natural product chemistry for identifying novel bioactive small molecules. 3. Biosynthetic studies of useful secondary metabolites in microorganisms and medicinal plants, and their application to combinatorial biosynthesis 4. Development of HCS (high-content screening) and HTS (high throughput screening) technologies for identifying useful bioactive small molecules). 5. Medicinal chemistry for development of new drug candi- Outline of Research Activities The main research fields are as follows: 1. Development of quantum chemical methods for very large molecules 2. Theoretical studies of structure and function of biomolecules 3. Development of computational methods for drug design 4. Exploratory research of novel lead compounds by structure based drug design Department of Integrated Genomics Professor KANEHISA, Minoru, D.Sc. (Univ. of Tokyo) Associate Professor GOTO, Susumu, D.Eng. (Kyushu Univ.) Assistant Professor HATTORI, Masahiro, D.Sc. (Kyoto Univ.) Assistant Professors TOKIMATSU, Toshiaki, D.Agr. (Kyoto Univ.) t KOTERA, Masaaki, D.Sc. (Kyoto Univ.) Outline of Teaching Activities The Department provides graduate students with bioinformatics courses relevant to pharmaceutical sciences, including sequence analysis, 3D structure analysis, genome information analysis, omics data analysis, pathway analysis, and chemoinformatics. Outline of Research Activities The main research fields are as follows: 1. Development of bioinformatics technologies for integrated analysis of genomics and chemistry 2. Drug target discovery from genomes through pathway analysis 3. Drug lead discovery from genomes through natural products 180 Department of Computational Genomics Professor MAMITSUKA, Hiroshi, D. Sci. (University of Tokyo) Assistant Professors TAKIGAWA, Ichigaku, D.Eng. (Hokkaido Univ.) SHIGA, Motoki, D.Eng. (Gifu Univ.) Outline of Teaching Activities This department is responsible for the following subjects in undergraduate as well as post-graduate courses: bioinformatics, computational biology, systems biology, pharmacoinformatics, computational genomics, chemoinformatics, and general techniques in computer science, like machine learning, data mining, pattern recognition and more general techniques in artificial intelligence. Outline of Research Activities With the recent advancement of experimental techniques in molecular biology, research in modern life science is shifting to the comprehensive understanding of a biological mechanism consisting of a variety of molecules. Our focus is placed on molecular mechanisms in biological phenomena, represented by biological networks such as metabolic and signal transduction pathways. Our research objective is to develop techniques based on computer science and/or statistics to systematically understand biological entities at the cellular and organism level. 5. CONTRIBUTED CHAIRS Department of Neuroscience for Drug Discovery (Endowed chair) Professor SUGIMOTO, Hachiro, D.Pharm.Sci. (Hiroshima Univ.) Associate Professor NIIDOME, Tetsuhiro, D.Pharm.Sci. (Kyushu Univ.) Lecturer KIHARA, Takeshi, D.Med.Sci. (Kyoto Univ.) Outline of Teaching Activities: The Laboratory focuses on development of new medicines targeting neurological diseases with the primary aim of developing new anti-Alzheimer’s drugs. The laboratory is responsible for providing training to graduate students in this field of study. The laboratory provides graduate students with advanced lectures in the mechanism of neurodegeneration based upon the beta-amyloid and cholinergic hypotheses. The discovery of seed compounds is the most important in drug development and the laboratory provides instructions and training in this area focusing on natural products. The laboratory also studies neurogenesis such as reconstruction of the neuron or glia which would have the potential to recover brain functions lost in cerebrovascular or neurodegenerative diseases. In-house seminars, reviews and discussions of recent important literatures are provided. Outline of Research Activities: The main research fields are as follows: 1. To elucidate the cause of neurodegeneration, e.g. Alz- heimer’s disease or Parkinson’s disease. 2. To develop new drugs for neurodegenerative diseases, especially anti-Alzheimer’s drugs. 3. To study the neuroprotective effect of acetylcholinesterase inhibitors against beta-amyloid or glutamate-induced cell death in vitro. 4. To study the mechanism underlying the (i) self-renewal/cell death/differentiation of neural stem cells, (ii) differentiation of microglia, and (iii) interaction between neural stem cells and microglia. Department of Nanobio Drug Discovery Professor SHIMIZU, Kazuharu, PhD. (Engineering, Tokyo Univ.) Associate Professor SATO, Fumiaki, MD. & PhD (Medicine, Kyoto Univ.) Assistant Professor TSUCHIYA, Soken, PhD. (Pharm., Kyoto Univ.) Outline of Teaching Activity The Laboratory is responsible for graduate instruction in DNA microarray-related research covering the basic concepts, wet lab techniques, bioinformatic analysis of DNA microarray. The Department provides graduate students with seminars, which review and discuss recent important nanobio technology. Laboratory practice in advance microarray and bioinformatic analysis is also provided. Outline of Research Activity 1. From mRNA expression profiling to “Taylor-made” therapy. 2. Functional analysis of microRNA 3. MicroRNA profiling for clinical diagnosis 4. MicroRNA therapy 5. Epigenetic control of mRNA and microRNA expression 6. Omics research using a next generation high throughput sequencer. Department of Systems Bioscience for Drug Discovery http://pharminfo.pharm.kyoto-u.ac.jp/ Professor OKUNO, Yasushi, D.Pharm.Sci. (Kyoto Univ.) Associate Professor SEGI-NISHIDA, Eri, D.Pharm.Sci. (Kyoto Univ.) Outline of Teaching Activities The Laboratory is responsible for general instruction in systems biology, molecular biology, bio/chemo-informatics and neuropharmacology for graduate students. The Department provides graduate students with seminars and laboratory practice in systems biology and molecular biology for drug discovery. Outline of Research Activities 1. Development of drug design theories based on chemical genomics and polypharmacology 2. Development of systems biological approaches for simulating of disease processes and drug actions 3. Identification of the molecular and cellular mechanisms t Pharmaceutical Sciences 181 hat underlie the actions of antidepressant drugs and stress 4. Exploration of the role of prostanoid in the stress responses and mood disorder 6. EDUCATION AND RESEARCH FACILITIES 1. Statistical modeling and simulation for individualized clinical drug therapy, and clinical pharmacology in drug development. 2. Clinical and non-clinical pharmacokinetic / pharmacodynamic analysispharmacy (clinical pharmacology, pharmacotherapy, and clinical drug development), and for practice of clinical data analysis. Center for Integrative Education of Pharmacy Frontier Department of Integrative Education of Pharmacy Professor SAKAEDA, Toshiyuki, D.Pharm.Sci. (Kyoto Univ.) Frontier Education Center Medical staff GP Professor SAJI, Hideo, D.Pharm.Sci. (Kyoto Univ.) Assistant Professor KUBOTA, Yoshie Outlines of Teaching Activities The Department is responsible for general undergraduate instruction and practice in clinical pharmacy, and for establishment the internet education system, i.e., “navigation system” and “e-learning system”, where general and/or professional lectures and their related tools as well as the information provided by professional staffs are disclosed for the students and community medical personnel, in collaboration with staffs of the faculty. Tutorial education programs are also provided for undergraduate students, which is the program of problem-based learning with small group discussion. Outlines of Teaching Activities The staffs are responsible for the program to support medical education corresponding to community health care needs and other social needs with newly developed novel subprograms as follows. 1. Navigation systems, where lectures and related tools provided by professional staff are disclosed to students via internet system. 2. Grid tutorial education program, which is the program of Outlines of Research Activities 1. Personalized medicine via therapeutic drug monitoring 2. Personalized medicine via pretreatment profiling of genetic properties 3. Personalized medicine via protein profiling 4. Drug discovery via transcriptome and proteome analysis Department of Advanced Pharmaceutical Sciences and Biotechnology Associate Professor TOCHIKURA,Tadafumi, D.V.M.,Ph.D. (Yamaguchi Univ.) problem-based learning with small group discussion. 3. English understanding and speaking program, provided by professional staff including native speakers. 4. Early exposure programs, including volunteer working in university and/or general hospitals and pharmacy, and visits to The Pharmaceuticals and Medical Devices Agency and other official organizations. 5. Integration programs, the co-education systems with students of the departments other than the Department of Pharmaceutical Sciences. Outline of Teaching Activities The Department is responsible for instruction in the training of undergraduate and graduate students in the areas of basic virology particularly associated with zoonotic potential, and applied virology focusing on virus-derived gene delivery system. Outline of Research Activities 1.Investigation into the mechanism for the acquisition of human cell tropism by feline immunodeficiency virus. 2.Study on the development of tissue-specific feline immunodeficiency virus vectors for use in human gene therapy. Department of Integrative Clinical Pharmacy Associate Professor YANO, Yoshitaka, D.Pharm.Sci. (Kyoto Univ.) Experimental Station For Medicinal Plants (affiliated with the Graduate School of Pharmaceutical Sciences) Associate Professor ITO, Michiho, D.Pharm.Sci. (Kyoto Univ.) The Experimental Station for Medicinal Plants covers an area of about 3000m2, and was founded in 1973. The station keeps various medicinal plants for education of undergraduate and graduate students, and for research activities. Some tropical plants and others are grown under controlled conditions in the station's greenhouse. The Station can functions not only as a specimen garden but also as an experimental institute. Outline of Teaching Activities The Department is responsible for creating integrative educational programs and e-learning systems for clinical pharmacy (clinical pharmacology, pharmacotherapy, and clinical drug development), and for practice of clinical data analysis. Outline of Teaching Activities The Station offers undergraduate instruction in the fundamental knowledge of medicinal plants (ethnobotany, taxonomy and chemotaxonomy, morphology, genetics, breeding, biosynthesis of secondary metabolites and biotechnology). Outline of Research Activities Outline of Research Activities 182 Main research fields are as follows: 1. Collection and propagation of important medicinal plant resources 2. Origin and phylogenetic relationship of the wild and cultivated Perilla plants 3. Field research of traditional medicines in Asian countries Support Program for Improving Graduate School Education (Graduate School of Pharmaceutical Sciences/Biostudies) Assistant Professors ONOHARA, Naoya, D.Pharm.Sci. (Kyushu Univ.) YAMAUCHI, Hajime, D.Pharm.Sci. (Kyoto Univ.) Service Innovation Program Assistant Professors SUZUKI, Chigure, M.D. (Juntendo Univ.), D.Med.Sci. (Osaka Univ.) INOKUMA, Tsubasa, M.Pharm.Sci. (Kyoto Univ.) Outlines of Teaching Activities The staffs are responsible for general undergraduate and graduate instruction and practice concerning the R&D activities in pharmaceutical companies and optimization of community pharmacotherapy, in collaboration with staffs of the faculty. The novel education programs are established for the students, and their goals are to become the clinical research coordinators, and community pharmacists and other medical staffs, respectively. Additionally, we aim at fostering novel personnel who can promote the innovation in Japanese health care system. The program is supported by the Ministry of Education, Culture, Sports, Science and Technology, Japan.