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WINONA STATE UNIVERSITY PROPOSAL FOR NEW COURSES Department ___Chemistry_______________________________________ Date ____9/13/04_______________ ___210_______________ Course No. ____Allied Health Chemistry___________________________________ ___5 SH________ Course Name Credits This proposal is for a(n) __XX__ Undergraduate Course ______ Graduate Course Applies to: ______ Major _____ Required _____ Elective Prerequisites __High school chemistry or CHEM 108 and MATH 100 or qualifying score on mathematics placement exam. Grading method __XX__ Grade only ______ Minor _____ Required _____ Elective ______ P/NC only ______ University Studies* ______ Grade and P/NC Option Frequency of offering _fall, spring_____________________ *For University Studies Program course approval, the form Proposal for University Studies Courses must also be completed. submitted according to the instructions on that form. Provide the following information (attach materials to this proposal): A. Course Description 1. 2. 3. 4. 5. 6. B. Rationale 1. 2. 3. C. Statement of the major focus and objectives of the course. Specify how this new course contributes to the departmental curriculum. Indicate any course(s) which may be dropped if this course is approved. Impact of this Course on other Departments, Programs, Majors, or Minors 1. 2. D. Catalog description. Course outline of the major topics and subtopics (minimum of two-level outline). Basic instructional plan and methods. Course requirements (papers, lab work, projects, etc.) and means of evaluation. Course materials (textbook(s), articles, etc.). List of references. Does this course increase or decrease the total credits required by a major or minor of any other department? If so, which department(s)? List the departments, if any, which have been consulted about this proposal. University Studies Course Proposals The form Proposal for University Studies Course must also be completed and submitted according to the instructions on that form. Attach a Financial and Staffing Data Sheet. Attach an Approval Form. Department Contact Person for this Proposal: ______________________________________________ Name (please print) A. Course Description ________________ Phone _______________________________ e-mail address 1. Catalog description A study of the principles of general, organic, and biological chemistry with emphasis on the numerous connections between chemistry and human health. Four lectures and one laboratory period per week. Prerequisites: high school chemistry or CHEM 108 and MATH 100 or qualifying score on mathematics placement exam. 2. Course outline Topic (Approximate number of lecture periods) Measurements (1) A. Physical Quantities a. Mass b. Length c. Volume B. Scientific Expression a. Notation b. Significant Figures Composition and Structure of Atoms, Elements and the Periodic Table (2) A. Elements and Atomic Number B. Iostopes and Atomic Weight C. Periodic Table a. Electronic Structure b. Electron Configurations Nuclear Chemistry (1) A. Isotopes B. Nuclear Reactions a. Decay b. Half-life C. Medical Uses Structure and Properties of Ionic and Covalent Bonds (2) A. Periodic Properties a. Ion Formation i. Octet Rule ii. Electron-Dot Symbols b. Molecular Compounds B. Ionic Bonds a. Biologically Important Ions b. Intro to Acid and Base Chemistry C. Covalent Bonds a. Molecular Structure b. Electronegativity and Polarity Calculations of Chemical Reactions and Equations (2) A. Chemical Equations a. Balancing b. Avogadro’s Number and the Mole i. Stoichiometric Relationships ii. Conversions c. Carbon Monoxide Poisoning B. Equation Calculations a. Conversions b. Theoretical and Percent Yield States of Matter- Gases, Liquids, and Solids (2) A. Gases a. Combined Gas Law i. Boyle’s Law 1. Blood Pressure ii. Charles’s Law iii. Gay-Lussac’s Law b. Ideal Gas Law B. Liquids C. Solids Chemical and Physical Change/ Energy, Rate and Equilibrium (2) A. Heat Changes in Reactions a. Exothermic Reactions b. Endothermic Reactions c. Free Energy B. Reaction Rates a. Catalysts b. Concentration c. Temperature C. Equilibrium a. Le Châtelier’s Principle Reactions and Solutions (2) A. Classes of Reactions a. Precipitation b. Acid/Base and Neutralization c. Oxidizing B. Properties of Solutions a. Liquids b. Gases i. Henry’s Law C. Concentrations a. Percentages i. Weight/Volume ii. Weight/Weight b. Solutions i. Molarity ii. Dilution D. Concentration-Dependent Properties a. Vapor Pressure b. Freezing Point Depression/Boiling Point Elevation c. Osmotic Pressure d. Oral Rehydration Therapy Acid-Base/ Oxidation-Reduction (2) A. Brønsted-Lowry Theory B. Conjugate Acids and Bases a. Strength b. Dissociation in Water i. pH 1. measuring 2. calculating b. Reactions C. Buffers a. Preparation b. Henderson-Hasselbalch equation D. Oxidation and Reduction Processes Alkanes, Haloalkanes (3) A. Structure and Physical Properties a. Hybridization b. Isomers c. Nomenclature B. Cycloalkanes a. Nomenclature b. Isomers C. Reactions D. Haloalkanes Alkenes, Aromatics, Alkynes (3) A. Alkenes a. Structure and Properties i. Hybridization ii. Isomers iii. Nomenclature b. Reactions i. Addition 1. Hydrogenation ii. 2. Halogenation Markovnikov’s Rule 1. Hydration 2. Hydrohalogenation iv. B. Aromatics a. Structure and Properties b. Nomenclature c. Reactions C. Alkynes a. Structure and Properties i. Hybridization Alcohols, Ethers, Thiols (2) A. Alcohols a. Structure and Properties i. Nomenclature ii. Classification b. Reactions i. Preparation ii. Oxidation iii. Dehydation c. Medically-Important Alcohols B. Phenols C. Ethers D. Thiols a. Reactions i. Oxidation ii. Reduction Carbohydrates (4) A. Types of Carbohydrates a. Monosaccharides i. Structure and Physical Properties ii. Stereoisomers 1. Optical Activity 2. Fischer Projections 3. D,L system b. Disaccharides i. Structure and Physical Properties ii. Biologically-Important 1. Linkages 2. Digestion iii. Blood Group Antigens c. Polysaccharides i. Biologically-Important Aldehydes, Ketones (2) A. Aldehydes a. Structure and Physical Properties b. Nomenclature c. Reactions i. Preparation ii. Reduction B. Ketones a. Structure and Physical Properties b. Nomenclature c. Reactions i. Preparation ii. Reduction iii. Keto-Enol Tautomerism iv. Aldol Condensation Carboxylic Acids, Amines, and Carboxylic Acid Derivatives (4) A. Carboxylic Acids a. Structure and Physical Properties b. c. B. Esters a. b. c. Nomenclature Reactions i. Preparation ii. Reduction iii. Esterification Structure and Physical Properties Nomenclature Reactions i. Preparation ii. Hydrolysis iii. Saponifcation d. Phosphoesters and Thioesters C. Acid Chlorides D. Acid Anhydrides E. Amines a. Structure and Physical Properties b. Nomenclature F. Amides a. Structure and Physical Properties b. Nomenclature Lipids and their Functions (4) A. Structure and Properties B. Biological Functions a. Chemical Reactions b. Physiological Function i. Fluid Mosaic Structure ii. Membrane Transport iii. Energy Requirements c. Types i. Fatty Acids 1. Tryiglycerides 2. Sphingolipids ii. Eicosanoids 1. Prostaglandins 2. Thromboxanes 3. Leukotrienes iii. Steroids Amino Acids, Proteins, and Enzymes (4) A. The Peptide Bond B. Proteins in the Blood C. Structure a. Primary i. Stereochemistry 1. D,L-system ii. Sequence 1. Notation 2. 3-D b. Secondary i. α-Helix ii. β-Pleated Sheet c. Tertiary i. Fibroin ii. Globular Proteins d. Quaternary i. Myoglobin ii. Hemoglobin D. Enzymes and Structure a. Classification b. Effects i. Activation Energy ii. Substrate Concentration iii. Temperature iv. pH c. Complexation i. Specificity ii. Allosteric d. Regulation i. Inhibition 1. Reversible 2. Irreversible ii. Feedback e. Clinical Perspectives Energy Production (2) A. Mitochondrial Structure B. Metabolism a. Kreb’s Cycle i. Control ii. Reactions b. Electron Transport i. Control ii. Reactions C. Degradation of Amino Acids a. Transamination b. Urea Cycle D. Anabolism Carbohydrate and Fatty Acid Metabolism (4) A. ATP a. Carbohydrate Metabolism i. Glycolysis 1. Control 2. Reactions ii. Pentose Phosphate Pathway iii. Gluconeogenesis iv. Glucogenesis b. Fatty Acid Metabolism i. Digestion and Absorption of Triglycerides 1. β-Oxidation 2. Glycerol ii. Ketone Bodies 1. Ketosis 2. Ketogenesis iii. Fatty Acid Synthesis iv. Regulation Nucleic Acids and Molecular Genetics (3) A. Introduction a. Nucleotides i. Structure of DNA/RNA ii. Replication B. Biological Information Flow a. RNA classes b. Transcription c. Protein Synthesis C. DNA Changes a. Mutations b. Engineering D. Sequencing 3. Instructional Plan Students will be introduced to the concepts outlined above. This introduction will include lecture, demonstrations and group work. The laboratory component will be used as a complement to the lecture to offer students a hands-on environment in working and experimenting with frequently-encountered topics. This real world experience will offer confirmation and understanding of chemistry and their application. Assessment of these plans includes quizzes, homework, exams, laboratory reports, and in-class feedback. 4. Course requirements Students are expected to have had high school chemistry or CHEM 108. In addition, they are required to have had MATH 100 or a qualifying score on the math entrance exam. Evaluation: Homework, laboratory reports, and exams (including ACS-standardized). B. 1. 5. Course materials There are a number of textbooks available including the currently used Denniston, K. J. Topping J. J. Caret, R. L.; General, Organic, and Biochemistry, 4th Ed.; McGraw Hill, Madison, WI 2004. Plus accompanying Laboratory textbook. 6. References Rationale Statement of the major focus and objectives of the course. The major objective of this course is to offer a connection between chemistry and allied health topics. Students in the health fields should be familiar with chemical concepts and how they are related to the physiological and biological sciences. The chemistry department would like to offer nursing and other allied health students a beneficial and appropriate chemistry course that meets the changing needs of their curriculum. This course presents the groundwork necessary to understand biochemical processes, including reaction analysis, conversions, and biochemical structure. This course will fulfill the chemistry requirement for the Nursing- Generic option major. 2. Specify how this new course contributes to the departmental curriculum. This course is considered a hybrid of two courses that are currently offered, CHEM 208 and CHEM 209. CHEM 210 will serve in the same capacity, meeting over one semester for 4 lecture periods and 1 lab period. 3. Indicate any course(s) which may be dropped if this course is approved. CHEM 208 and CHEM 209 (4 credits each) will be dropped. C. Impact of the course on others A reduction of 3 SH results in the Nursing – Generic option major. Chemistry and nursing department representatives have worked together toward a common result. The recently submitted revised nursing major includes this new course. II. WINONA STATE UNIVERSITY FINANCIAL AND STAFFING DATA SHEET Course or Program____CHEM 210______________________________ Include a Financial and Staffing Data Sheet with any proposal for a new course, new program, or revised program. Please answer the following questions completely. Provide supporting data. 1. Would this course or program be taught with existing staff or with new or additional staff? If this course would be taught by adjunct faculty, include a rationale. Existing staff would teach this course. This course will be offered instead of CHEM 208 and CHEM 209. 2. What impact would approval of this course/program have on current course offerings? Please discuss number of sections of current offerings, dropping of courses, etc. The chemistry department would plan to offer 5-7 lab sections of this course divided among 2-3 lecture sections each semester. We currently offer 7 sections each of 208 (fall) and 209 (spring). 3. What effect would approval of this course/program have on the department supplies? Include data to support expenditures for staffing, equipment, supplies, instructional resources, etc. None – this will be offered in place of existing courses.