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Cellular Respiration
9-1 Chemical Pathways
• A calorie is the amount of energy needed to
raise the temperature of 1 gram of water 1
Celsius degree.
• The Calorie (capital “C”) that is used on food
labels is a kilocalorie, or 1000 calories.
• We burn glucose when we release energy from
glucose through cellular respiration
• This process begins with a pathway called
glycolysis – the first step in releasing the
energy of glucose, in which a molecule of
glucose is broken into two molecules of pyruvic
acid
Overview of Cellular Respiration
• Where does photosynthesis take place?
– Chloroplast
• Where does glycolysis occur?
– Cytoplasm
• Where does cellular respiration take
place?
– mitochondria
Cellular Respiration
• Cellular respiration is the process that
releases energy by breaking down food
molecules in the presence of oxygen.
Glycolysis takes place in the cytoplasm. The Krebs
cycle and electron transport takes place inside the
mitochondria.
Glycolysis
• Glycolysis is the process in which one
molecule of glucose is broken in half,
producing two molecules of pyruvic acid, a
3-carbon compound.
Glycolysis
• Takes place in the Cytoplasm
• Does not require oxygen
• ATP and NADH – carrier molecules
– 2 ATP added to glucose
– Results in 2-3 carbon compounds
– They then become 2 pyruvic acids, when this
happens 4 ATP and 2 NADH are made
Glycolysis cont.
•
Glycolysis is an energy-releasing process
– the cell needs energy to start the glycolysis
process
•
•
•
2 ATP molecules are needed to get
glycolysis started
When glycolysis is complete, 4 ATP
molecules are produced.
The cell has a net gain of 2 ATP
molecules.
Honors Glycolysis cont.
• 4 ATP and 2 NADH are made
• During glycolysis 4 high-energy electrons are removed
and passed to an electron carrier called NAD+
• each NAD+ accepts a pair of high-energy electrons.
This molecule, known as NADH, holds the electrons
until they can be transferred to other molecules. By
doing this, NAD+ helps to pass energy from glucose to
other pathways in the cell.
• Besides speed, another advantage is that glycolysis
itself does not require oxygen. This means that
glycolysis can supply chemical energy to cells when
oxygen is not available.
• Electron Carrier – a compound that can
accept a pair of high energy electrons and
transfer them along with most of their
energy to another molecule.
• Example – frying pan, electrons were the
coals
Review
Fermentation
• Fermentation releases energy from food
molecules in the absence of oxygen.
• Anaerobic– “not in air” happens when oxygen
is not present (fermentation does not require
oxygen)
• NADH is converted to NAD+ by passing highenergy electrons back to pyruvic acid.
• This allows glycolysis to continue producing a
steady supply of ATP.
2 Types of Fermentation
•
•
•
The two main types of fermentation are
alcoholic fermentation and lactic acid
fermentation.
Yeasts and a few other microorganisms use
alcoholic fermentation, forming ethyl alcohol
and carbon dioxide as wastes.
Helps bread dough rise – yeast in the dough
runs out of oxygen, it begins to ferment, giving
off bubbles of CO2 which form the air spaces
you see in a slice of bread.
Lactic Acid Fermentation
Pyruvic acid accumulates = to make lactic acid
• In many cells, the pyruvic acid that accumulates
as a result of glycolysis can be converted to
lactic acid.
• Lactic acid made during rapid exercise, when
oxygen is not available to the muscles
• Results in painful, burning sensation, causes
sore muscles
9-2
The Krebs Cycle and Electron
Transport
• At the end of glycolysis, about 90 percent
of the chemical energy that was available
in glucose is still unused
• Because the pathways of cellular
respiration require oxygen, they are said to
be aerobic.
The Kreb Cycle
• In the presence of oxygen, pyruvic acid
produced in glycolysis passes to the second
stage of cellular respiration, the Krebs cycle.
• During the Krebs cycle, pyruvic acid is broken
down into carbon dioxide in a series of energyextracting reactions.
• Because citric acid is the first compound formed
in this series of reactions, the Krebs cycle is
also known as the citric acid cycle.
Honors Electron Transport
• electron transport chain is a series of
proteins in which the high-energy
electrons from the Krebs cycle are
used to convert ADP into ATP
The Totals
• The complete
breakdown of
glucose through
cellular
respiration,
including
glycolysis, results
in the production
of 36 molecules of
ATP.
Totals
• Recall that glycolysis produces just 2 ATP
molecules per glucose. In the absence of
oxygen, that is all the energy that a cell
can extract from each molecule of
glucose.
• What happens to the remaining 62
percent?
– It is released as heat, which is one of the
reasons your body feels warmer after
vigorous exercise, and you do not freeze
in winter.
Energy and Exercise
•
•
•
•
•
To obtain energy, the body uses
1. ATP already in muscles
2. new ATP made by lactic acid fermentation
3. new ATP made by cellular respiration.
(Cells normally contain small amounts of ATP
produced during glycolysis and cellular
respiration. These sources can usually supply
enough ATP to last about 90 seconds. )
Energy and Exercise cont.
• The only way to get rid of lactic acid is in a chemical
pathway that requires extra oxygen
• For exercise longer than about 90 seconds, cellular
respiration is the only way to generate a continuing
supply of ATP.
• These stores of glycogen are usually enough to last
for 15 or 20 minutes of activity. After that, your body
begins to break down other stored molecules,
including fats, for energy. This is one reason why
aerobic forms of exercise such as running, dancing,
and swimming are so beneficial for weight control.
Comparing Photosynthesis and
Cellular Respiration
• Photosynthesis is the process that
“deposits” energy. Cellular respiration is
the process that “withdraws” energy.