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General Psychology Scripture • Matthew 5:5 "Blessed are the meek, for they will inherit the earth. Happy are the meek - They that hold all their passions and affections evenly balanced. They shall inherit the earth - They shall have all things really necessary for life and godliness. The Endocrine System The endocrine system refers to a set of glands that produce chemical messengers called hormones. The Body’s “Slow but Sure” Endocrine Message System The endocrine system sends molecules as messages, just like the nervous system, but it sends them through the bloodstream instead of across synapses. These molecules, called hormones, are produced in various glands around the body. The messages go to the brain and other tissues. Adrenal Glands produce hormones such as adrenaline/epinephrine, noradrenaline/norepinephrine, and cortisol. Adrenal Glands Pancreas 1. The sympathetic “fight or flight” nervous system responds to stress by sending a message to adrenal glands to release the hormones listed above. 2. Effect: increased heart rate, blood pressure, and blood sugar. These provide ENERGY for the fight or flight! The Pituitary Gland The pituitary gland is the “master gland” of the endocrine system. It is controlled through the nervous system by the nearby brain area--the hypothalamus. The pituitary gland produces hormones that regulate other glands such as the thyroid. It also produces growth hormone (especially during sleep) and oxytocin, the “bonding” hormone. Pituitary gland Investigating the Brain and Mind: How did we move beyond phrenology? How did we get inside the skull and under the “bumps”? by finding what happens when part of the brain is damaged or otherwise unable to work properly by looking at the structure and activity of the brain: CAT, MRI, fMRI, and PET scans Strategies for finding out what is different about the mind when part of the brain isn’t working normally: case studies of accidents (e.g. Phineas Gage) case studies of split-brain patients (corpus callosum cut to stop seizures) lesioning brain parts in animals to find out what happens chemically numbing, magnetically deactivating, or electrically stimulating parts of the brain Studying cases of brain damage When a stroke or injury damages part of the brain, we have a chance to see the impact on the mind. “He was no longer Gage…” Before • – efficient foreman • – well-balanced mind • – shrewd smart business man After • – Fitful • – Irreverent, and grossly profane • – Little deference for his fellows • – Impatient and obstinate, yet capricious and • vacillating • – Poor planning There is a Phineas Gage display in the Warren Medical Museum at Harvard University • This is what went through his brain… Intentional brain damage: Lesions (surgical destruction of brain tissue) performed on animals has yielded some insights, especially about less complex brain structures no longer necessary, as we now can chemically or magnetically deactivate brain areas to get similar information 12 Clinical Observation Clinical observations have shed light on a number of brain disorders. Alterations in brain morphology due to neurological and psychiatric diseases are now being catalogued. Tom Landers/ Boston Globe Split-Brain Patients “Split” = surgery in which the connection between the brain hemispheres is cut in order to end severe full-brain seizures Study of split-brain patients has yielded insights discussed at the end of the chapter Images of Brain Activity Normal Child Institutionalized Romanian Orphan Dark tones show brain areas such as the temporal lobes, which oversee emotion among other functions, are practically inactive in the Romanian child compared to the healthy child. We can stimulate parts of the brain to see what happens Parts of the brain, and even neurons, can be stimulated electrically, chemically, or magnetically. This can result in behaviors such as giggling, head turning, or simulated vivid recall. Researchers can see which neurons or neural networks fire in conjunction with certain mental experiences, and even specific concepts. Monitoring activity in the brain Tools to read electrical, metabolic, and magnetic activity in the brain: EEG: electroencephalogram PET: positron emission tomography MRI: magnetic resonance imaging fMRI: functional MRI EEG: electroencephalogram An EEG (electroencephalogram) is a recording of the electrical waves sweeping across the brain’s surface. An EEG is useful in studying seizures and sleep. 19 PET: positron emission tomography The PET scan allows us to see what part of the brain is active by tracing where a radioactive form of glucose goes while the brain performs a given task. MRI: magnetic resonance imaging MRI (magnetic resonance imaging) makes images from signals produced by brain tissue after magnets align the spin of atoms. The arrows below show ventricular enlargement in a schizophrenic patient (right). fMRI: functional MRI Functional MRI reveals brain activity and function rather than structures. Functional MRI compares successive MRI images taken a split second apart, and shows changes in the level of oxygen in bloodflow in the brain. 21 Areas of the brain and their functions The brainstem and cerebellum: The limbic (border) system: The cortex (the outer covering): • coordinates the body • manages emotions, and connects thought to body • integrates information The Brainstem: Pons and Medulla The Base of the Brainstem: The Medulla The medulla controls the most basic functions such as heartbeat and breathing. Someone with total brain damage above the medulla could still breathe independently, but someone with damage in this area could not. The Brainstem: The Pons The pons helps coordinate automatic and unconscious movements. The Thalamus (“Inner Chamber”) The thalamus is the “sensory switchboard” or “router.” All sensory messages, except smell, are routed through the thalamus on the way to the cortex (higher, outer brain). The thalamus also sends messages from the cortex to the medulla and cerebellum. Reticular (“Netlike”) Formation The reticular formation is a nerve network in the brainstem. It enables alertness, (arousal) from coma to wide awake (as demonstrated in the cat experiments). It also filters incoming sensory information. Cerebellum (“little brain”) The cerebellum helps coordinate voluntary movement such as playing a sport. The cerebellum has many other functions, including enabling nonverbal learning and memory. The Limbic (“Border”) System The limbic system coordinates: emotions such as fear and aggression. basic drives such as hunger and sex. the formation of episodic memories. The hippocampus (“seahorse”) processes conscious, episodic memories. works with the amygdala to form emotionally charged memories. The Amygdala (“almond”) consists of two lima beansized neural clusters. helps process emotions, especially fear and aggression. The Amygdala Electrical stimulation of a cat’s amygdala provokes aggressive reactions. If you move the electrode very slightly and cage the cat with a mouse, the cat will cower in terror. The Hypothalamus: lies below (“hypo”) the thalamus. regulates body temperature and ensures adequate food and water intake (homeostasis), and is involved in sex drive. directs the endocrine system via messages to the pituitary gland. Thalamus The Hypothalamus as a Reward Center Riddle: Why did the rat cross the grid? Why did the rat want to get to the other side? Pushing the pedal that stimulated the electrode placed in the hypothalamus was much more rewarding than food pellets. Review of Brain Structures Caution • One should be wary of using pictures of brain “hot spots” to create a new phrenology that locates complex functions in precise brain areas (Uttal, 2001). • Mental functions don’t reside in any one place. Memory, language, and attention result from the synchronized activity among distinct brain areas (Knight, 2007). Aoccdrnig to a rseearch sduty at Cmabrigde Uinervtisy, it deosn't mttaer in waht oredr the ltteers in a wrod are, the olny iprmoetnt tihng is taht the frist and lsat ltteer be at the rghit pclae. The rset can be a total mses and you can sitll raed it wouthit a porbelm.Tihs is bcuseae the huamn mnid deos not raed ervey lteter by istlef, but the wrod as a wlohe. What Do You See ? THE END……DNE EHT