Download Myocardial infarction

Myocardial infarction
Definition
Myocardial infarction (MI) is a heart attack that occurs when oxygenated blood vessels become blocked. The portion of heart muscle
that was deprived of oxygen may die or become permanently damaged (Discovermi.org - SNM, 2011).
Role of molecular imaging
After a heart attack, heart function can be evaluated using either echocardiography or nuclear imaging. Molecular and functional
imaging procedures assess heart function and provide valuable information on specific biochemical and structural changes in heart
tissue, including (Discovermi.org - SNM, 2011):
 Extent of scarring
 Degree of coronary artery disease
 Left ventricle remodeling (changes in the size, shape, and function of the heart after injury)
 Development of congestive heart failure
Radiopharmaceutical
Manufacturer
Flourine-18
fluorodeoxyglucose
Various
MPI viability
Nitrogen-13 ammonia
Various
PET agent used for evaluation of
myocardial blood flow (perfusion)
Rubidim-82 chloride
Bracco Diagnostics
Technetium-99m
pyrophosphate
Covidien
Pharmalucence
Technetium-99m sestamibi
Cardinal Health
Covidien
DRAXIMAGE
Lantheus Medical
Imaging
Pharmalucence
Technetium-99m tetrofosmin
GE Healthcare
Trade names
Approved indications in adults
Cardiogen-82
PET myocardial perfusion agent that is useful in
distinguishing normal from abnormal
myocardium in patients with suspected
myocardial infarction
Technescan™ PYP™-
As a cardiac imaging agent used as an adjunct
in the diagnosis of acute myocardial infarction
As a blood pool imaging agent useful for: gated
blood pool imaging
®
®
Myocardial perfusion agent that is indicated for:
 Detecting coronary artery disease by
localizing myocardial ischemia
(reversible defects) and infarction (nonreversible defects)
 Evaluating myocardial function
 Developing information for use in
patient management decisions
Myoview™
Myocardial perfusion agent that is indicated for:
 Detecting coronary artery disease by
localizing myocardial ischemia
(reversible defects) and infarction (nonreversible defects)
 The assessment of left ventricular
function (left ventricular ejection
fraction and wall motion)
Cardiolite
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CARE are trademarks or registered trademarks of Cardinal Health. All other marks are the property of their
respective owners.
.
Radiopharmaceutical
Manufacturer
Trade names
Thallium-201 chloride
Covidien
GE Healthcare
Lantheus Medical
Imaging
Pharmacological stress
agents
Manufacturer
Trade names
Adenosine
Astellas
Adenoscan
Regadenoson
Astellas
Lexiscan
Dipyridamole
Various
Approved indications in adults
Useful in myocardial perfusion imaging for the
diagnosis and localization of myocardial
infarction
 As an adjunct in the diagnosis of
ischemic heart disease (atherosclerotic
coronary artery disease)
®
®
Approved indications in adults
Pharmacologic stress agent used in patients
with an intermediate-to-high pretest likelihood of
CAD who are unable to exercise
Pharmacologic stress agent indicated for
radionuclide MPI in patients unable to undergo
adequate exercise stress
IV injection is a coronary vasodilator
MSDS and package insert information
© 2015 Cardinal Health. All rights reserved. CARDINAL HEALTH, the Cardinal Health LOGO and ESSENTIAL TO
CARE are trademarks or registered trademarks of Cardinal Health. All other marks are the property of their
respective owners.
.