Download Coronary artery disease

Coronary artery disease
Definition
Coronary artery disease (CAD) is a common disease that causes the restricting of the artery passages that supply blood and oxygen to
the heart. An accumulation of plaque in the arteries results in restriction of blood and oxygen to the heart (Discovermi.org - SNM, 2011).
In 2009, the National Vital Statistics Reports claimed that diseases of the heart were the top leading cause of death in the United States
for both men and women (by Kenneth D. Kochanek, Jiaquan Xu, Sherry L. Murphy, M.P.H., & and Hsiang-Ching Kung, 2011).
Role of molecular imaging
Myocardial perfusion imaging (MPI) and positron emission tomography (PET) imaging studies help:
 Diagnose and provide a prognosis of CAD.
 Evaluate a patient’s response to CAD treatment.
 Identify patients who may benefit from revascularization, or coronary bypass surgery. (Discovermi.org - SNM, 2011)
Radiopharmaceutical
Manufacturer
Flourine-18
fluorodeoxyglucose
Various
MPI viability
Nitrogen-13 ammonia
Various
PET agent used for evaluation of
myocardial blood flow (perfusion)
Rubidim-82 chloride
Bracco Diagnostics
Technetium-99m sestamibi
Cardinal Health
Covidien
DRAXIMAGE
Lantheus Medical
Imaging
Pharmalucence
Technetium-99m tetrofosmin
GE Healthcare
Thallium-201 chloride
Covidien
GE Healthcare
Lantheus Medical
Imaging
Trade names
®
Cardiogen-82
Approved indications in adults
PET myocardial perfusion agent that is useful in
distinguishing normal from abnormal
myocardium in patients with suspected
myocardial infarction
®
Myocardial perfusion agent that is indicated for:
 Detecting coronary artery disease by
localizing myocardial ischemia
(reversible defects) and infarction (nonreversible defects)
 Evaluating myocardial function
 Developing information for use in
patient management decisions
Myoview™
Myocardial perfusion agent that is indicated for:
 Detecting coronary artery disease by
localizing myocardial ischemia
(reversible defects) and infarction (nonreversible defects)
 The assessment of left ventricular
function (left ventricular ejection
fraction and wall motion)
Cardiolite
Useful in myocardial perfusion imaging for the
diagnosis and localization of myocardial
infarction
 As an adjunct in the diagnosis of
ischemic heart disease (atherosclerotic
coronary artery disease)
© 2015 Cardinal Health. All rights reserved. CARDINAL HEALTH, the Cardinal Health LOGO and ESSENTIAL TO
CARE are trademarks or registered trademarks of Cardinal Health. All other marks are the property of their
respective owners.
.
Pharmacological stress
agents
Manufacturer
Trade names
Adenosine
Astellas
Adenoscan
Regadenoson
Astellas
Lexiscan
Dipyridamole
Various
®
®
Approved indications in adults
Pharmacologic stress agent used in patients
with an intermediate-to-high pretest likelihood of
CAD who are unable to exercise
Pharmacologic stress agent indicated for
radionuclide MPI in patients unable to undergo
adequate exercise stress
IV injection is a coronary vasodilator
MSDS and package insert information
© 2015 Cardinal Health. All rights reserved. CARDINAL HEALTH, the Cardinal Health LOGO and ESSENTIAL TO
CARE are trademarks or registered trademarks of Cardinal Health. All other marks are the property of their
respective owners.
.