Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Sharon E. Oberfield, M.D. Professor of Pediatrics at CUMC Director, Division of Pediatric Endocrinology Diabetes and Metabolism Research Summary: Address: Division of Pediatric Endocrinology NewYork-Presbyterian Morgan Stanley Children's Hospital 622 West 168th Street PH-5E-522 New York, NY 10032 Phone: (212) 305-6559 Fax: (212) 305-4778 Email: [email protected] I am a Professor of Pediatrics and have been Division Director of Pediatric Endocrinology, Diabetes, and Metabolism at Columbia University Medical Center since 2004. Since 1998, I have been the Program Director of the Fellowship Training program in Pediatric Endocrinology and the PI of a T32 training grant in Pediatric Endocrinology from the NIH National Institute of Diabetes, Digestive and Kidney Diseases since 2005. I have been engaged in patient-oriented research for my entire career with a particular focus on disorders of adrenal hormone synthesis and adrenarche and PCOS. I have also conducted studies of body composition in children. I continue to be involved in multiple studies of childhood obesity. My expertise in clinical research will enable me to devise and assist in many of the proposed studies conducted at the New York Obesity Research Center. As a participant in their current grants I have interacted with both Drs. Gallagher and Ferrante. Further, since 1998, I have mentored 21 fellows and more than 30 pre-doctoral students including Endocrine Society, DERC, and Doris Duke summer fellows. I have the expertise, background, and training to serve as a mentor, responsible for pediatric training in endocrine metabolism, including studies related to obesity. Most importantly, my clinical research has centered around the developmental/pediatric endocrinology, specifically the HPA axis which intimately effects metabolic function, interacting with adiposity, including studies of body composition and adrenarche/PCOS areas of investigation by the NYORC. Selected Publications: 1. Adrenal Disorders. As a fellow in pediatric endocrinology at Cornell University Medical Center, I was awarded an NIH funded Research Service Award which resulted in the development of normative data for mineralocorticoid levels in childhood, as well as the determination of the responses of steroid hormones to short and long term infusion with ACTH in normal and patient populations with disorders of adrenal hormone synthesis. Pursuing these studies as the first NIH funded Clinical Research Fellow (CAP) of the Cornell Pediatric Clinical Research Center, I initiated protocols to define the pathophysiology of pseudohypoaldosteronism leading to the first description of multiple target organ insensitivity to mineralocorticoid hormones in this disorder. I investigated the role of adrenal steroid hormones in mineralocorticoid hypertension. a. Oberfield SE, Levine LS, Carey RM, Bejar R, New MI. Pseudohypoaldosteronism: multiple target organ unresponsiveness to mineralocorticoid hormones. J Clin Endocrinol Metab. 1979 Feb;48(2):228-34. PubMed PMID: 218983. b. Oberfield SE, Levine LS, Stoner E, Chow D, Rauh W, et al. Adrenal glomerulosa function in patients with dexamethasone-suppressible hyperaldosteronism. J Clin Endocrinol Metab. 1981 Jul;53(1):158-64. PubMed PMID: 7016891. c. Oberfield SE, Levine LS, Carey RM, Greig F, Ulick S, et al. Metabolic and blood pressure responses to hydrocortisone in the syndrome of apparent mineralocorticoid excess. J Clin Endocrinol Metab. 1983 Feb;56(2):332-9. PubMed PMID: 6296185. d. Oberfield SE, Mayes DM, Levine LS. Adrenal steroidogenic function in a black and Hispanic population with precocious pubarche. J Clin Endocrinol Metab. 1990 Jan;70(1):76-82. PubMed PMID: 2152934. 2. Endocrine Effects of Oncologic Disorders of Children. Post fellowship I spent a year at Memorial Sloan Kettering Cancer Center and began to describe deleterious effects of oncologic disease and their effects on the endocrine system. a. Oberfield SE, Allen JC, Pollack J, New MI, Levine LS. Long-term endocrine sequelae after treatment of medulloblastoma: prospective study of growth and thyroid function. J Pediatr. 1986 Feb;108(2):219-23. PubMed PMID: 3944706. b. Oberfield SE, Nino M, Riddick L, Pang S, Nagel M, et al. Combined bromocriptine and growth hormone (GH) treatment in GH-deficient children with macroprolactinoma in situ. J Clin Endocrinol Metab. 1992 Jul;75(1):87-90. PubMed PMID: 1619034. c. Oberfield SE, Nirenberg A, Allen JC, Cohen H, Donahue B, et al. Hypothalamic-pituitary-adrenal function following cranial irradiation. Horm Res. 1997;47(1):916. PubMed PMID: 9010712. d. Oberfield SE. Childhood cancer cures: the ongoing consequences of successful treatments. J Pediatr. 2007 Apr;150(4):332-4. PubMed PMID: 17382105. 3. Body Composition and Bone Mineral Density in Childhood and Adolescence. Initially in collaboration with Dr. Horlick, of the Pediatric Body Composition Lab, and later as site PI of NO1 HD 1 3332-08 (Bone Mineral Density in Childhood Study), I participated in new efforts to evaluate body composition in children with normal and altered growth and puberty. A seminal paper was published describing bone mineral content and density according to age, sex and race and the team continues to analyze the data although the study is complete. This work has been applied to ongoing studies in adrenarche, obesity, and the PCOS population. a. Kalkwarf HJ, Zemel BS, Gilsanz V, Lappe JM, Horlick M, et al. The bone mineral density in childhood study: bone mineral content and density according to age, sex, and race. J Clin Endocrinol Metab. 2007 Jun;92(6):208799. PubMed PMID: 17311856. b. Zemel BS, Leonard MB, Kelly A, Lappe JM, Gilsanz V, et al. Height adjustment in assessing dual energy x-ray absorptiometry measurements of bone mass and density in children. J Clin Endocrinol Metab. 2010 Mar;95(3):1265-73. PubMed PMID: 20103654; PubMed Central PMCID: PMC2841534. c. Kelly A, Winer KK, Kalkwarf H, Oberfield SE, Lappe J, et al. Age-based reference ranges for annual height velocity in US children. J Clin Endocrinol Metab. 2014 Jun;99(6):2104-12. PubMed PMID: 24601728; PubMed Central PMCID: PMC4037731. 4. Insulin Resistance and Metabolic Dysregulation in Children and Adolescents. I have continued to expand my studies of hyperandrogenic states including adrenarche and PCOS, and the interrelationship of insulin resistance, increased androgens, altered growth factors and lipid dysfunction. With my past fellows, we described the use of the fasting glucose to insulin ratio (FGIR) as a simple and useful measure of insulin resistance in at risk groups. With Dr. Accili, I've noted changes in proinsulin levels in a large population of young girls with premature adrenarche and obesity. I have demonstrated the presence of elevated free IGF-1 in prepubertal girls with premature adrenarche and described altered insulin sensitivity in boys with premature adrenarche. In a pilot study I determined altered intramyocellular lipids in leg muscle in prepubertal girls with premature adrenarche. Along with Dr. Sopher, I am currently assessing intrahepatic lipid content in the PCOS population in collaboration with the division of Functional Radiology and Dr. D. Gallagher. I have supported the activities of the Center for Adolescent Bariatric Surgery and with Drs. Fennoy, Jean, Korner, and fellows, we have has begun to explore alterations in androgen, lipids, and adipokines in patients following laparoscopic banding. a. Silfen ME, Manibo AM, McMahon DJ, Levine LS, Murphy AR, et al. Comparison of simple measures of insulin sensitivity in young girls with premature adrenarche: the fasting glucose to insulin ratio may be a simple and useful measure. J Clin Endocrinol Metab. 2001 Jun;86(6):2863-8. PubMed PMID: 11397901. b. Sopher AB, Thornton JC, Silfen ME, Manibo A, Oberfield SE, et al. Prepubertal girls with premature adrenarche have greater bone mineral content and density than controls. J Clin Endocrinol Metab. 2001 Nov;86(11):5269-72. PubMed PMID: 11701690. c. Silfen ME, Manibo AM, Ferin M, McMahon DJ, Levine LS, et al. Elevated free IGF-I levels in prepubertal Hispanic girls with premature adrenarche: relationship with hyperandrogenism and insulin sensitivity. J Clin Endocrinol Metab. 2002 Jan;87(1):398-403. PubMed PMID: 11788683. d. Chin D, Oberfield SE, Silfen ME, McMahon DJ, Manibo AM, et al. Proinsulin in girls: relationship to obesity, hyperinsulinemia, and puberty. J Clin Endocrinol Metab. 2002 Oct;87(10):4673-7. PubMed PMID: 12364457. 5. Endocrine Disruptors. I have spearheaded a collaboration with the investigators at the CCCEH at Columbia University Medical Center and we have begun to assess the effects of endocrine disruptors on pubertal development and thyroid dysfunction as a part of a longitudinal NIH/NIEHS funded study. a. Rundle A, Hoepner L, Hassoun A, Oberfield S, Freyer G, et al. Association of childhood obesity with maternal exposure to ambient air polycyclic aromatic hydrocarbons during pregnancy. Am J Epidemiol. 2012 Jun 1;175(11):1163-72. PubMed PMID: 22505764; PubMed Central PMCID: PMC3491973. b. Kahn LG, Liu X, Rajovic B, Popovac D, Oberfield S, et al. Blood lead concentration and thyroid function during pregnancy: results from the Yugoslavia Prospective Study of Environmental Lead Exposure. Environ Health Perspect. 2014 Oct;122(10):1134-40. PubMed PMID: 24866691; PubMed Central PMCID: PMC4181923. c. Mueller NT, Whyatt R, Hoepner L, Oberfield S, Dominguez-Bello MG, et al. Prenatal exposure to antibiotics, cesarean section and risk of childhood obesity. Int J Obes (Lond). 2014 Nov 11;PubMed PMID: 25298276. More about Sharon E. Oberfield, M.D.: Link to CV