Download Faculty Profile - New York Obesity Nutrition Research Center

Sharon E. Oberfield, M.D.
Professor of Pediatrics at CUMC
Director, Division of Pediatric Endocrinology Diabetes and
Metabolism
Research Summary:
Address:
Division of Pediatric
Endocrinology
NewYork-Presbyterian Morgan
Stanley Children's Hospital
622 West 168th Street
PH-5E-522
New York, NY 10032
Phone: (212) 305-6559
Fax: (212) 305-4778
Email: [email protected]
I am a Professor of Pediatrics and have been Division Director of
Pediatric Endocrinology, Diabetes, and Metabolism at Columbia
University Medical Center since 2004. Since 1998, I have been
the Program Director of the Fellowship Training program in
Pediatric Endocrinology and the PI of a T32 training grant in
Pediatric Endocrinology from the NIH National Institute of
Diabetes, Digestive and Kidney Diseases since 2005. I have been
engaged in patient-oriented research for my entire career with
a particular focus on disorders of adrenal hormone synthesis
and adrenarche and PCOS. I have also conducted studies of
body composition in children. I continue to be involved in
multiple studies of childhood obesity. My expertise in clinical
research will enable me to devise and assist in many of the
proposed studies conducted at the New York Obesity Research
Center. As a participant in their current grants I have interacted
with both Drs. Gallagher and Ferrante. Further, since 1998, I
have mentored 21 fellows and more than 30 pre-doctoral
students including Endocrine Society, DERC, and Doris Duke
summer fellows. I have the expertise, background, and training
to serve as a mentor, responsible for pediatric training in
endocrine metabolism, including studies related to obesity.
Most importantly, my clinical research has centered around the
developmental/pediatric endocrinology, specifically the HPA
axis which intimately effects metabolic function, interacting
with adiposity, including studies of body composition and
adrenarche/PCOS areas of investigation by the NYORC.
Selected Publications:
1. Adrenal Disorders. As a fellow in pediatric endocrinology at
Cornell University Medical Center, I was awarded an NIH
funded Research Service Award which resulted in the
development of normative data for mineralocorticoid levels in
childhood, as well as the determination of the responses of
steroid hormones to short and long term infusion with ACTH in
normal and patient populations with disorders of adrenal
hormone synthesis. Pursuing these studies as the first NIH
funded Clinical Research Fellow (CAP) of the Cornell Pediatric
Clinical Research Center, I initiated protocols to define the
pathophysiology of pseudohypoaldosteronism leading to the
first description of multiple target organ insensitivity to
mineralocorticoid hormones in this disorder. I investigated the
role of adrenal steroid hormones in mineralocorticoid
hypertension.
a. Oberfield SE, Levine LS, Carey RM, Bejar R, New MI.
Pseudohypoaldosteronism: multiple target organ
unresponsiveness to mineralocorticoid hormones. J Clin
Endocrinol Metab. 1979 Feb;48(2):228-34. PubMed
PMID: 218983.
b. Oberfield SE, Levine LS, Stoner E, Chow D, Rauh W, et
al. Adrenal glomerulosa function in patients with
dexamethasone-suppressible hyperaldosteronism. J
Clin Endocrinol Metab. 1981 Jul;53(1):158-64. PubMed
PMID: 7016891.
c. Oberfield SE, Levine LS, Carey RM, Greig F, Ulick S, et al.
Metabolic and blood pressure responses to
hydrocortisone in the syndrome of apparent
mineralocorticoid excess. J Clin Endocrinol Metab. 1983
Feb;56(2):332-9. PubMed PMID: 6296185.
d. Oberfield SE, Mayes DM, Levine LS. Adrenal
steroidogenic function in a black and Hispanic
population with precocious pubarche. J Clin Endocrinol
Metab. 1990 Jan;70(1):76-82. PubMed PMID: 2152934.
2. Endocrine Effects of Oncologic Disorders of Children. Post
fellowship I spent a year at Memorial Sloan Kettering
Cancer Center and began to describe deleterious effects of
oncologic disease and their effects on the endocrine
system.
a. Oberfield SE, Allen JC, Pollack J, New MI, Levine LS.
Long-term endocrine sequelae after treatment of
medulloblastoma: prospective study of growth and
thyroid function. J Pediatr. 1986 Feb;108(2):219-23.
PubMed PMID: 3944706.
b. Oberfield SE, Nino M, Riddick L, Pang S, Nagel M, et al.
Combined bromocriptine and growth hormone (GH)
treatment in GH-deficient children with
macroprolactinoma in situ. J Clin Endocrinol Metab.
1992 Jul;75(1):87-90. PubMed PMID: 1619034.
c. Oberfield SE, Nirenberg A, Allen JC, Cohen H, Donahue
B, et al. Hypothalamic-pituitary-adrenal function
following cranial irradiation. Horm Res. 1997;47(1):916. PubMed PMID: 9010712.
d. Oberfield SE. Childhood cancer cures: the ongoing
consequences of successful treatments. J Pediatr. 2007
Apr;150(4):332-4. PubMed PMID: 17382105.
3. Body Composition and Bone Mineral Density in Childhood
and Adolescence. Initially in collaboration with Dr. Horlick,
of the Pediatric Body Composition Lab, and later as site PI
of NO1 HD 1 3332-08 (Bone Mineral Density in Childhood
Study), I participated in new efforts to evaluate body
composition in children with normal and altered growth
and puberty. A seminal paper was published describing
bone mineral content and density according to age, sex and
race and the team continues to analyze the data although
the study is complete. This work has been applied to
ongoing studies in adrenarche, obesity, and the PCOS
population.
a. Kalkwarf HJ, Zemel BS, Gilsanz V, Lappe JM, Horlick M,
et al. The bone mineral density in childhood study:
bone mineral content and density according to age, sex,
and race. J Clin Endocrinol Metab. 2007 Jun;92(6):208799. PubMed PMID: 17311856.
b. Zemel BS, Leonard MB, Kelly A, Lappe JM, Gilsanz V, et
al. Height adjustment in assessing dual energy x-ray
absorptiometry measurements of bone mass and
density in children. J Clin Endocrinol Metab. 2010
Mar;95(3):1265-73. PubMed PMID: 20103654; PubMed
Central PMCID: PMC2841534.
c. Kelly A, Winer KK, Kalkwarf H, Oberfield SE, Lappe J, et
al. Age-based reference ranges for annual height
velocity in US children. J Clin Endocrinol Metab. 2014
Jun;99(6):2104-12. PubMed PMID: 24601728; PubMed
Central PMCID: PMC4037731.
4. Insulin Resistance and Metabolic Dysregulation in Children
and Adolescents. I have continued to expand my studies of
hyperandrogenic states including adrenarche and PCOS,
and the interrelationship of insulin resistance, increased
androgens, altered growth factors and lipid dysfunction.
With my past fellows, we described the use of the fasting
glucose to insulin ratio (FGIR) as a simple and useful
measure of insulin resistance in at risk groups. With Dr.
Accili, I've noted changes in proinsulin levels in a large
population of young girls with premature adrenarche and
obesity. I have demonstrated the presence of elevated free
IGF-1 in prepubertal girls with premature adrenarche and
described altered insulin sensitivity in boys with premature
adrenarche. In a pilot study I determined altered
intramyocellular lipids in leg muscle in prepubertal girls
with premature adrenarche. Along with Dr. Sopher, I am
currently assessing intrahepatic lipid content in the PCOS
population in collaboration with the division of Functional
Radiology and Dr. D. Gallagher. I have supported the
activities of the Center for Adolescent Bariatric Surgery and
with Drs. Fennoy, Jean, Korner, and fellows, we have has
begun to explore alterations in androgen, lipids, and
adipokines in patients following laparoscopic banding.
a. Silfen ME, Manibo AM, McMahon DJ, Levine LS,
Murphy AR, et al. Comparison of simple measures of
insulin sensitivity in young girls with premature
adrenarche: the fasting glucose to insulin ratio may be
a simple and useful measure. J Clin Endocrinol Metab.
2001 Jun;86(6):2863-8. PubMed PMID: 11397901.
b. Sopher AB, Thornton JC, Silfen ME, Manibo A, Oberfield
SE, et al. Prepubertal girls with premature adrenarche
have greater bone mineral content and density than
controls. J Clin Endocrinol Metab. 2001
Nov;86(11):5269-72. PubMed PMID: 11701690.
c. Silfen ME, Manibo AM, Ferin M, McMahon DJ, Levine
LS, et al. Elevated free IGF-I levels in prepubertal
Hispanic girls with premature adrenarche: relationship
with hyperandrogenism and insulin sensitivity. J Clin
Endocrinol Metab. 2002 Jan;87(1):398-403. PubMed
PMID: 11788683.
d. Chin D, Oberfield SE, Silfen ME, McMahon DJ, Manibo
AM, et al. Proinsulin in girls: relationship to obesity,
hyperinsulinemia, and puberty. J Clin Endocrinol Metab.
2002 Oct;87(10):4673-7. PubMed PMID: 12364457.
5. Endocrine Disruptors. I have spearheaded a collaboration
with the investigators at the CCCEH at Columbia University
Medical Center and we have begun to assess the effects of
endocrine disruptors on pubertal development and thyroid
dysfunction as a part of a longitudinal NIH/NIEHS funded
study.
a. Rundle A, Hoepner L, Hassoun A, Oberfield S, Freyer G,
et al. Association of childhood obesity with maternal
exposure to ambient air polycyclic aromatic
hydrocarbons during pregnancy. Am J Epidemiol. 2012
Jun 1;175(11):1163-72. PubMed PMID: 22505764;
PubMed Central PMCID: PMC3491973.
b. Kahn LG, Liu X, Rajovic B, Popovac D, Oberfield S, et al.
Blood lead concentration and thyroid function during
pregnancy: results from the Yugoslavia Prospective
Study of Environmental Lead Exposure. Environ Health
Perspect. 2014 Oct;122(10):1134-40. PubMed PMID:
24866691; PubMed Central PMCID: PMC4181923.
c. Mueller NT, Whyatt R, Hoepner L, Oberfield S,
Dominguez-Bello MG, et al. Prenatal exposure to
antibiotics, cesarean section and risk of childhood
obesity. Int J Obes (Lond). 2014 Nov 11;PubMed PMID:
25298276.
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