Download Origins of neural crest cells and cranial placodes at the edge of the

Origins of neural crest cells and cranial
placodes at the edge of the neural plate
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Gilbert6
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neural crest migration
In ovo time-lapse analysis of chick hindbrain neural crest cell migration shows cell interactions during migratio
the branchial arches
Paul M. Kulesa and Scott E. Fraser
Thursday, April 24, 14
neural crest migration
In ovo time-lapse analysis of chick hindbrain neural crest cell migration shows cell interactions during migratio
the branchial arches
Paul M. Kulesa and Scott E. Fraser
Thursday, April 24, 14
Thursday, April 24, 14
Thursday, April 24, 14
Trunk neural crest migration pathways
Gilbert6
Thursday, April 24, 14
Neural crest migrates
over and through the
anterior sclerotome (of
the somite), but not
the posterior, due to
repulsion from the
posterior sclerotome.
Gilbert6
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Mutant in neuropilin shows a loss of segmentation
Guidance of trunk neural crest migration requires neuropilin 2/semaphorin 3F signaling.
Gammill LS, Gonzalez C, Gu C, Bronner-Fraser M.
Development. 2006 Jan;133(1):99-106. Epub 2005 Nov 30.
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Semaphorin is expressed
on the posterior somite
Guidance of trunk neural crest migration requires neuropilin 2/
semaphorin 3F signaling.
Gammill LS, Gonzalez C, Gu C, Bronner-Fraser M.
Development. 2006 Jan;133(1):99-106. Epub 2005 Nov 30.
8
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Lineage tracing shows that neural crest
cells are not committed to specific fates
as they emigrate from the neural tube
Gilbert6
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Neural crest
migration
pathways and
derivatives
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Trunk neural crest cells:
Sensory neurons of
dorsal root ganglia,
Sympathetic neurons
and ganglia
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Melanocytes from neural crest cells
Gilbert6
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cells that
migrate past
the BMP
producing
aorta, are
induced to
become
neurons (of
the
sympathetic
ganglia)
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Patterning of the hindbrain
from Kiecker and Lumsden, 2005
The midbrain-hindbrain boundary acts
as an “isthmic organizer
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The Hox code of rhombomeres r1-r8
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Rhombomeres: repeating branchiomo
bomere-spe
morphological and
genic line i
organizational units of the gene regula
hindbrain (here in the zebrafish)
Fig. 3. Cranial neuroanatomy reflects the segmental organization of
the zebrafish hindbrain. A: The individually identified reticulospinal neurons are organized in a ladder-like array along the anterior-posterior
extent of the hindbrain (anterior to the top). Note the large bilateral
Mauthner neurons with contralateral projections in r4 (arrow). B: The
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fromeven-numbered
Moens andrhombomeres,
Prince,2002
ilarly exit from
where
neuronal differentiation is similarly delayed in oddnumbered rhombomeres (Bally-Cuif et al., 1998; Higashijima et al., 2000) and where cranial neural crest
similarly migrates from even-numbered rhombomeres
the Hox
ment ide
PATTE
AX
fig.7 of Moens
and Prince,2002
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Compartments (intrinsic segmentation) in the hindbrain
Lumsden A, 2004
Rhombomeres (in the chick) are visible as local “bumps” of
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increased proliferation, and as units of axonal projection
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Compartments (intrinsic segmentation) in the hindbrain
Lumsden A, 2004
Rhombomeres become lineage restriction units, at about the ten somite
stage (stage X)
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Cranial neural crest, rhombomeres, and
branchial arches
Gilbert6
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Cranial placodes and their
derivatives, from Streit, 2008
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The lens placode and lens
development
an example of reciprocal interaction between optic cup and epithelium
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Separation of the eye fields requires
hedgehog signaling
Text
Text
see also Gilbert6
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