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The Respiratory System Major Function of the Respiratory System: To supply the body with O2 and dispose of CO2 Processes involved in respiration Ventilation-movement of air into and out of the lungs External respiration- gas exchange between the blood (pulmonary capillaries) and the airsacs (alveoli) in the lungs Transport of respiratory gases- movement of O2 and CO2 between the lungs and the tissues Internal respiration- gas exchange between the blood (tissue capillaries) and tissue cells * cellular respiration- utilization of O2 by cells for energy (ATP) production via oxidative phosphorylation Basic Anatomy of the Respiratory System Figure 22.1 Basic Anatomy of the Respiratory System Upper Respiratory Tract Organs nasal cavity, pharynx, larynx Accessory structures: oral cavity, sinuses Lower Respiratory Tract Organs trachea, bronchi, bronchioles, alveoli Basic Anatomy of the Respiratory System Figure 22.1 Respiratory Mucosa mucous membrane lining the respiratory tract from the nasal cavity (and sinuses) to the bronchioles epithelial layer is comprised predominantly of ciliated, simple columnar epithelial cells, with mucous-secreting goblet cells interspersed No cilia or goblet cells in smallest bronchioles or alveoli Respiratory Mucosa Conducting Zone- structures from the nasal cavity up to and including the terminal bronchioles Respiratory Zone- respiratory bronchioles (with attached alveoli) through the alveolar sacs up to nasal cavity Fig 22.7 Alveoli Microscopic sacs where gas (O2/Co2) exchange occurs; lined with simple squamous epithelium (called type I cells or Type I pneumocytes) Alveoli Figure 22.9c (not required) Alveoli, together with the pulmonary capillary endothelium→form the respiratory membrane Alveoli Microscopic sacs where gas (O2/Co2) exchange occurs; lined with simple squamous epithelium (called Type I cells or Type 1 pneumocytes) Alveoli, together with the pulmonary capillary endothelium→form the respiratory membrane (also called the alveolar-capillary membrane). Site of external respiration. The thinness of the squamous alveolar cells and the pulmonary capillary endothelial cells makes the respiratory membrane very thin to allow efficient O2/CO2 exchange Pleurae- serous membranes covering the lungs; contain pleural fluid protect and lubricate the lungs Pleurae- serous membranes covering the lungs; contain pleural fluid protect and lubricate the lungs The two pleurae are separate sacs