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USING GOLD TO TREAT BRAIN CANCER
Havisha Garimella
Independent Research G/T
Mount Hebron High School
Dr. Hinkal(Staff in the Department of
Nanotechnology at NIH)
Dr. Kiehl
PREVIEW
Using nanomedicine to treat brain cancer
interests me because it allows for a faster and
more innovative way to deliver toxic drugs.
 This presentation will include background
information regarding my topic and paper, the
status of my project, and the goals for my
product.
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RESEARCH QUESTION AND HYPOTHESIS
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Research Question: How can gold nanoparticles
enhance and effect the target delivery of drugs to
tumors when bonded to tumor necrosis factor alpha and
thiolyated polyethylene glycol?
Hypothesis: If the gold nanoparticle is attached to the
tumor-killing agent, tumor necrosis factor alpha (TNF)
and the polymer thiolyated polyethylene glycol , then
high doses of it can be used for delivery because the
nanoparticle acts like a shield, preventing the leakage of
TNF into the bloodstream
BACKGROUND INFORMATION
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Thesis: High doses of TNF-alpha can be used for delivery
when the gold nanoparticle is attached to the tumorkilling agent and thiolyated polyethylene glycol.
Tumor nercosis factor alpha, or TNF-alpha, is one of the
drugs sometimes used to treat brain cancer
Since TNF-alpha is very toxic, its uses are very limited.
Gold nanoparticles are super small pieces of gold in a
fluid
Gold nanoparticle holds the drug, and acts like a shield,
preventing the drug from being released into the
bloodstream
…BACKGROUND INFORMATION
The main concern is that TNF is highly toxic, and if
released into the bloodstream, it can injure one’s
health.
 Thiolyated polyethylene glycol is a polymer
attached to the nanoparticle that takes the
particle directly to the site of the tumor. This
means that normal tissue would not be damaged
since the medicine is not given to the entire area
of the brain, but rather just the tumor.
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SYNTHESIS PAPER INFORMATION
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Paper exposes gold
nanoparticles and how
they can be a viable
option for treating brain
cancer. Readers will learn
about what gold
nanoparticles are their
uses, and some benefits
and drawbacks.
ASPECTS OF SYNTHESIS PAPER
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The gold nanoparticles, when bonded with a specific polymer
such as thiolyated polyethylene glycol, attracts to
giloblastoma. Giloblastoma is what is found in tumors
(Abner, 2011).
Once the gold nanoparticle reaches the tumor, light/heat is
placed at the area, causing it to melt. Medicine is released
once the gold shell has melted. The TNF-alpha, which rapidly
produces many cell deaths, reacts within the tumor. The
tumor than subsidizes (Pesic, 2004).
A benefit is that is does not damage healthy tissue
A drawback is that many nanoparticles will be needed since
they are very small (0.0000000001 size).
PROJECT
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Contacts of a list of doctors and scientists have been made
Emails have been sent out to them asking to be interviewed,
and if they would be willing to read my synthesis paper
Their responses and comments will be compiled into a chart
Data will analyzed by comparing the opinions of various
professionals, and seeing if they feel gold nanoparticles are
a viable option
Graphs/charts will be created comparing opinions of various
people ranging from professionals to ordinary people, who
do not now much regarding the topic
PRODUCT
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The product will be an informative pamphlet/packet that
talks about this new form of treatment. It will inform
readers of this new potential form of treatment that will
be implemented soon.
The charts and responses of what was said by the
professionals will be used to support why this form of
treatment is good or to point out its drawbacks.
The pamphlet/packet will be given to the staff at the
NIH Department of Cancer and Department of
Nanotechnology; they are my audience.
It is through my advisor that I will be able to distribute
the product since he works at NIH.
CONCLUSION
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Brain cancer is the second leading cause of
cancer-related death in children. Children
diagnosed with malignant brain tumors have
only a 60 percent survival rate. Of those who
do survive, they are diagnosed with disabilities
and serious, long-term health problems due to
the intensive brain surgeries and treatment. It
is important to minimize the potential for failure
and risk by first fixing the drug-delivery
technique we have now.
WORKS CITED
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Abner, A. (2011). Gold seeds: targeting cancer. Mount
Auburn Hospital Health Connection. Retrieved from
http://www.mountauburnhealthconnection.com
[Attacking cancer with drug carriers]. Retrieved from
http://www.ereleases.com/pic/Syracuse-gold-nano.jpg
[Gold nanoparticle]. Retrieved from
http://www.topnews.in/healthcare/content/-2652goldnanoparticles-may-carry-multiple-drugs-treat-cancer
Pesic, A. (2004). Syracuse team use gold nanoparticles to
deliver DOX anti-cancer drug . in-Pharma Technologist .
Retrieved from http://www.inpharmatechnologist.com/Materials Formulation/Syracuseteam-use-gold-nanoparticles-to-deliver-DOX-anti-cancer-drug