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GVN Virology: July 13-19, 2014 Confirmed Faculty Robert C. Gallo Prof. Robert Gallo is Founder and Director of the Institute of Human Virology (IHV) at the University of Maryland. Prior to this role, he spent 30 years at the National Institutes of Health's National Cancer Institute, where he was head of its Laboratory of Tumor Cell Biology. Dr. Gallo is renowned for his research on HIV, most notably his co-discovery in 1984 that HIV is the cause of AIDS. His research has been instrumental to the development of HIV blood tests and HIV therapies. In 1996, his discovery that a natural compound known as chemokines can block HIV and halt the progression of AIDS was hailed by Science magazine as one of that year’s most important scientific breakthroughs. Dr. Gallo’s current work at the IHV combines the disciplines of research, patient care, and prevention programs in a concerted effort to speed the pace of medical breakthroughs. Dr. Gallo has authored more than 1,200 scientific publications, as well as the book "Virus Hunting: AIDS, Cancer & the Human Retrovirus: A Story of Scientific Discovery." Dr. Gallo has been awarded 31 honorary doctorates and was twice a recipient of the Albert Lasker Clinical Medical Research Award (1982 and 1986). He is a member of the National Academy of Sciences and the Institute of Medicine. William Blattner William A. Blattner, MD is Co-Founder and Associate Director of the Institute of Human Virology (IHV) and Professor of Medicine and Chief, Division of Cancer Epidemiology at University of Maryland, School of Medicine. He is an internationally recognized authority on HIV/AIDS and has a long track record of domestic and global health leadership. He co-founded the Institute of Human Virology at the University of Maryland with Drs. Robert C. Gallo and Robert R. Redfield. He is a pioneer in research studies of the first human retrovirus, HTLV-1 and the AIDS virus, HIV-1. Blattner not only has substantial experience of direct relevance to HIV program management, he is also is an internationally recognized research scientist who has authored or co-authored over 350 peer reviewed papers, 70 book chapters and made numerous scientific presentations at national and international meetings. He has served in advisory capacity to NIH, CDC, US Military and to numerous pharmaceutical and biomedical industry leaders. From 2003 – 2012, he has served as a Mayoral appointee to the Baltimore Commission on HIV/AIDS and provided strategic guidance to the City and its Health Department on implementing well- coordinated and evidence-based programs. C. David Pauza Dr. Pauza received the PhD in 1981 from the University of California, Berkeley. From 1981-1985, he was a postdoctoral fellow and staff member of the Laboratory of Molecular Biology at the Medical Research Council, Cambridge, England. In 1985 Dr. Pauza moved to the Salk Institute for Biological Studies in La Jolla, California where he started the AIDS Research Program and guided its development until 1990 when he accepted an appointment at the University of Wisconsin-Madison. Dr. Pauza created the Immunology and Virology Division at the Wisconsin National Primate Center and established strong interdisciplinary programs in AIDS involving basic, clinical, and animal models research. After 10 years at the University of Wisconsin, Dr. Pauza moved to the Institute of Human Virology as Professor in the Basic Science Division and, since 2004, Assistant Director. In addition to 25 years in laboratory, animal model and clinical studies on HIV/AIDS, Dr. Pauza has an active program in tumor immunology with efforts to pioneer new approaches for clinical management of disease through immunotherapy. Dr. Pauza has authored over 160 original monographs and is actively funded by the National Institutes of Health, USA and by the Gates Foundation. Robert Redfield Dr. Robert R. Redfield has been actively engaged in clinical research and clinical care of chronic human viral infections and infectious diseases, especially HIV, for more than 30 years. He served as the founding director of the Department of Retroviral Research within the Military’s HIV Research Program and retired after 20 years of service in the US Army Medical Corp when he co-founded the University of Maryland’s Institute of Human Virology with Dr. William Blattner and Dr. Robert C. Gallo. He is currently a Professor of Medicine, Professor of Microbiology and Immunology, and serves as the IHV Associate Director and Director of the Division of Clinical Care and Research. Dr. Redfield made several important early contributions to our understanding of HIV, to include the demonstration of the importance of heterosexual transmission and the development of the Walter Reed staging system for HIV infection. Presently, Dr. Redfield oversees an extensive clinical program providing HIV care and treatment to more than 5,000 patients in the Baltimore/Washington DC community. He also leads extensive USG funded global care and treatment, and post-graduate medical education programs, which are currently active in 5 African and 2 Caribbean countries. Matthew Frieman Dr. Frieman is an Assistant Professor of Microbiology & Immunology in the University of Maryland School of Medicine in Baltimore. His laboratory focuses on coronavirus research including SARS and MERS. Yutaka Tagaya Dr. Tagaya is Head, T-cell Biology Lab, Division of Basic Sciences and Vaccine Research, Institute of Human Virology, at the University of Maryland School of Medicine. Dr. Tagaya received his M.D. and Ph.D. degrees from Kyoto University Medical School, and completed postdoctoral studies at the National Cancer Institute. While at the NCI, Dr. Tagaya made seminal discoveries in the field of cytokine biology. He has been recognized as one of the international leaders in this field. He has discovered a unique way IL-15 functions in vivo (trans-presentation paradigm) and generated animal models to study the biology of cytokines and, through his work, has demonstrated a direct correlation between cytokines and some illnesses such as leukemia and autoimmune diseases. Currently Dr. Tagaya's group at the IHV studies the molecular mechanism of CD8 T cell differentiation in special connection to a transcription factor IRF-8. Dr. Tagaya's group is also developing novel anti-cytokine drugs that may be used to treat autoimmune and inflammatory diseases using the animal models his group has generated in the past. His group also studies the leukemic mechanism associated with HTLV-1. His bibliography contains more than 60 publications in reputed journals in the field of cytokine biology, molecular and cellular immunology. David Thomas David L. Thomas, M.D., is a world-renowned expert on hepatitis C and has been a faculty member at The Johns Hopkins University School of Medicine since 1993. He has been Director of the School’s Division of Infectious Diseases since 2006. Dr. Thomas has focused most of his research efforts over the past two decades on liver infections, especially the causes and treatments for hepatitis C, the leading cause of liver disease in the United States and an infection that kills an estimated 10,000 to 12,000 Americans each year. He is author of hundreds of articles and many book chapters on various aspects of hepatitis, and has also investigated how co-infections with hepatic C viruses and HIV progress in intravenous drug users with weakened immune systems. Rohit Talwani Dr. Talwani is Medical Director of the Hepatitis Clinical Unit at the US Veterans Affairs Medical Center in Baltimore and an Assistant Professor at the University of Maryland Medical School. He is an infectious disease specialist, specializing in the treatment of chronic hepatitis infection. Dr. Talwani received his M.D. from the University of South Carolina in 1995. He completed an internship in internal medicine at Rush University Medical Center followed by a residency at the University of South Carolina. He completed his infectious diseases fellowship at Rush University Medical Center in 2000 and is currently board certified in infectious diseases and internal medicine. S. Diane Hayward Dr. Hayward is Professor of Oncology, Neurology, Pharmacology & Molecular Science at Johns Hopkins University. She is a recognized expert on Epstein-Barr virus (EBV) and Kaposi’s sarcoma associated herpesvirus (KSHV) - human herpesviruses that are associated with a variety of malignancies. She is a Director of the Herpesvirus Research Program at the Sidney Kimmel Comprehensive Cancer Center at Hopkins. Dr. Hayward’s research interests include EBV and KSHV, viral latency and tumorigenesis, mechanisms of virus induced proliferation, and herpesvirus proteomics. Her renowned research is well recognized in the cancer field, as she twice received the Merit Award from the National Cancer Institute, from 1988 to 1995 and more recently from 2002 to 2011. Konstantin Chumakov Dr. Konstantin Chumakov is an Associate Director for Research at the Office of Vaccines Research and Review at the US Food and Drugs Administration. He holds a PhD (1979) in molecular virology and Doctor of Sciences degree (1987) from Moscow State University. In 1973-1987 he was a Research Scientist at the Laboratory of Molecular Biology and Bioorganic Chemistry of Moscow State University. From 1987 to 1989, he was a Chief of the Laboratory of Bacterial Genetics at the Institute of Microbiology of the Soviet Academy of Sciences in Moscow. In 1989 he moved to the FDA Center for Biologics Evaluation and Research (CBER) in Bethesda, Maryland, and since 1997 heads the Laboratory of Method Development in the Division of Viral Products, CBER. His scientific interests are in molecular virology and bioinformatics, creation of molecular methods for evaluation and quality control of vaccines and other biological products as well as development of new approaches for control and elimination of viral diseases. He is an author of more than 150 scientific papers in scientific journals and book chapters. Diane Griffin Dr. Griffin is the Alfred and Jill Sommer Professor and Chair in Molecular Microbiology and Immunology at the Bloomberg School of Public Health at Johns Hopkins University. She is recognized as a world renowned expert in measles. Dr. Griffin has studied the host immune responses to viral infections since her early days at Johns Hopkins University. Her career has centered on two primary areas of research including the neurovirulence of Sindbis virus and immunosuppression induced by human measles virus. This knowledge has been critical to her latest vaccine efforts using Sindbis virus particles expressing the measles hemagglutinin protein. Her studies pinpoint the difficulty involved in clearing measles virus from the human body. Furthermore, her work may lead to a new vaccine that could be delivered to infants in developing countries where this virus is still a major public health problem. She is a member of the American Academy of Microbiology, US National Academy of Sciences, Institute of Medicine, the Maryland Women's Hall of Fame, and has received the Pioneer Award from the International Society for Neurovirology. Peter Palese Dr. Palese is Professor and Chair of the Department of Microbiology in the Icahn School of Medicine at Mount Sinai in New York. He is known worldwide for his expertise in the field of RVA viruses to include influenza, paramyxo and corona (SARS) viruses. His research group is interested in fundamental questions concerning the genetic make-up and the biology of viruses using molecular biological techniques to understand how viruses replicate and how they interact with cells to cause disease in their hosts. Dr. Palese is the author of multiple book chapters and more than 300 scientific publications. He is on the editorial board for Proceedings of the National Academy of Sciences and has been awarded multiple patents on viral vaccines and antivirals. Palese is a member of the US National Academy of Sciences, the Institute of Medicine, the Austrian Academy of Sciences, and the German Academy of Sciences Leopoldina. Among his honors are the Robert Koch Prize, the Charles C. Shepard Science Award, the European Virology Award, and the Sanofi-Institut Pasteur Award. Mike Levine Dr. Levine has been Director of the University of Maryland Center for Vaccine Development since its inception in 1974 and has created an academic vaccinology environment that is rich in intellectual ferment and stimulation. Dr. Levine is clinically trained in pediatrics and pediatric infectious diseases and is also trained in tropical public health and epidemiology. Dr. Levine has published over 460 peer reviewed journal articles, is an inventor or co-inventor on many issued patents and is Senior Editor of New Generation Vaccines, a textbook of research vaccinology. He was elected to the Institute of Medicine of the National Academy of Science, the Association of American Physicians, the American Society of Clinical Investigation and the Interurban Clinical Club. He is the recipient of the Albert B. Sabin Gold Medal Award for lifetime achievement in the area of vaccine development and implementation and has also received the Merck-Hilleman Award, the American Society for Microbiology’s premier award for major contributions to pathogenesis, vaccine discovery, vaccine development, and control of vaccine preventable diseases. Jose Esparza Dr. Esparza is an internationally recognized expert on global health, vaccinology and HIV/AIDS. From 2004 to 2014 he was with the Bill & Melinda Gates Foundation in Seattle WA, first as Senior Advisor on HIV Vaccines and subsequently as Senior Advisor on Global Health (Vaccines.) Now retired from the Gates Foundation and living in Reston VA, Dr. Esparza provides expert advice to different organizations. From 1974 to 1986 he worked at the Venezuelan Institute of Scientific Research, one of the most important research institutions in Latin America, where he became Professor of Virology and Chair of the Center for Microbiology and Cell Biology. He published seminal work in the field of rotaviruses, combining basic science with epidemiology and clinical work. From 1986 to 2004 Dr. Esparza worked with the World Health Organization (WHO) and the Joint United Nations Programme on HIV/AIDS (UNAIDS), in Geneva, Switzerland, where he became a global leader in the field of HIV vaccines. Dr. Esparza is author of over 180 publications, and has served in numerous advisory committees all over the world. He is a member of the Venezuelan Academy of Medicine and of the Royal Academy of Doctors of Spain. Barry Beaty Dr. Beaty is known internationally for his work and leadership in infectious diseases. His major research efforts have been in the epidemiology and control of vector-borne and rodent-borne diseases. His work to understand the epidemic and evolutionary potential of diseases, such as dengue, yellow fever, West Nile fever, LaCrosse encephalitis, and hantavirus pulmonary syndrome, and to control these dread diseases is and has been funded by the National Institutes of Health, the Centers for Disease Control, the World Health Organization, the MacArthur Foundation, the Gates Foundation and other agencies. Beaty is also known internationally for his research in mosquito vector biology, molecular biology, vector pathogen interactions, and vector control. Dr. Beaty is a Member of the National Academy of Sciences, a fellow of the American Academy of Microbiology, and a CSU University Distinguished Professor. At CSU, Dr. Beaty was the founder and former Director of the Arthropod-borne Infectious Diseases Laboratory, Director of the Rocky Mountain Regional Center of Excellence for Biodefense and Emerging Infectious Diseases, and Director of the Infectious Disease Supercluster and Chief Scientific Officer of MicroRx, the business arm of the ID SC. Connie Schmaljohn Dr. Schmaljohn is an internationally recognized expert on hantaviruses and hemorrhagic fever with renal syndrome. Following postdoctoral research, she joined the Virology Division at USAMRIID in 1983 and served as Chief of the Molecular Virology Branch from 1992-2006. Her current position is as the Army's Senior Research Scientist for Medical Defenses Against Infectious Diseases (ST). She is one of less than 40 Army senior professional scientists. Dr. Schmaljohn's research focuses on basic molecular virology research and on the design and testing of molecular vaccines for highly pathogenic viruses, to include Phase 1 clinical testing of DNA vaccines for hemorrhagic fever with renal syndrome and Venezuelan equine encephalitis virus. She is the author of more than 120 research publications, holds numerous patents and serves on several editorial boards. Dr. Schmaljohn was elected to the American Academy of Microbiology in 2007 and is currently the President of the International Society for Hantaviruses. Schmaljohn received a Ph.D. in Microbiology/Virology from Colorado State University in 1978. Lisa Hensley Lisa E. Hensley is the Associate Director of Science at the Office of the Chief Scientist, National Institute of Allergy and Infectious Disease Integrated Research Facility in Frederick, Maryland. She was previously a civilian microbiologist in the virology division of the United States Army Medical Research Institute of Infectious Diseases (USAMRIID). Hensley is one of the premier researchers of some of the world’s most dangerous infections, including Ebola hemorrhagic fever, Severe Acute Respiratory Syndrome (SARS), and smallpox. She has been involved in research uncovering critical mechanisms in the pathogenesis of hemorrhagic fever viruses, and has used those discoveries to develop candidate therapeutic drugs for their treatment. Hensley joined USAMRIID in 1998 as a research associate in the Pathology Division. She has co-authored over 56 publications in peer-reviewed scientific journals on a variety of infectious disease topics. Reed Shabman Dr. Reed Shabman is an Infectious Disease Investigator at the J. Craig Venter Institute (JCVI). The goal of Dr. Shabman’s current research is to understand the interplay between zoonotic viruses and their hosts. Specific areas of interest include defining the host immune response following infection, identifying unique mechanisms of viral gene expression, and discovering novel viral innate immune evasion strategies. Knowledge within these areas will aid in the development of successful vaccines and therapeutics to counteract virus infection. His most recent work is focused on the highly virulent filoviruses (Ebola and Marburg virus), which are classified as NIAID Category A Priority Pathogens and CDC Bioterrorism Agents. To accomplish these research goals, Dr. Shabman is actively integrating next generation sequencing technologies at JCVI. Dr. Shabman received his Ph.D. in 2008 from the Department of Microbiology and Immunology at the University of North Carolina at Chapel Hill. Sharon H. Hrynkow Dr. Sharon Hrynkow has worked in the global health arena for more than 20 years. In 2012, she was appointed as the first President of the Global Virus Network where she is responsible for managing GVN operations centrally and working with GVN Centers of Excellence worldwide to advance the GVN mission (www.gvn.org). Prior positions include leadership roles at the National Institutes of Health, where she was Deputy Director and Acting Director of the John E. Fogarty International Center (2000-2007) and Associate Director of the National Institute of Environmental Health Sciences. She has worked in partnership with more than 100 countries worldwide to build capacity and collaborations in biomedicine and global health, including on malaria, AIDS, emerging infectious diseases and brain disorders in developing countries. She developed critical NIH programs to train next generation researchers in global health in the United States and internationally. Early in her career, she served as the focal point on HIV/AIDS at the US Department of State, and was responsible for the State Department's first International Strategy on HIV/AIDS. Among her awards are the King of Norway's Order of Merit and the U.S. President's Rank Award for Meritorious Senior Executive. She is an elected member of the Council on Foreign Relations. ###