Download deCODE PrOstatECanCEr™ Genetic Risk

for patients
About Prostate Cancer
deCODE
ProstateCancer™
Prostate cancer is the most common non-skin
cancer in the United States and the second
leading cause of cancer death in men.
Early diagnosis is critical. When diagnosed and
treated early, over 90 percent of prostate cancer
can be cured.
Genetic Risk Assessment Test
ARUP Is a nonprofit enterprise of the University of Utah and its Department of Pathology.
If you are age 40 or over, consider having regular
PSA screening prior to a complete risk assessment.
A complete risk assessment includes a prostate
exam, PSA blood test, evaluation of family history,
and a prostate ultrasound and/or biopsy when
indicated.
See the American Urological Association (AUA)
website for additional recommendations.
www.aruplab.com
ARUP LABORATORIES
500 Chipeta Way
Salt Lake City, UT 84108-1221
Phone: (800) 522-2787
Fax: (801) 583-2712
May 2012
© 2012 ARUP Laboratories
National Reference Laboratory
deCODE ProstateCancer™ | Genetic Risk Assessment Test
what you need to know
About the Test
I am African American, Hispanic, or Asian. Can my
doctor order this test for me?
Do I need to take the deCODE ProstateCancer Genetic
Risk Assessment test periodically, like PSA?
What is the intended purpose of the deCODE
ProstateCancer™ Genetic Risk Assessment test?
No. The test is only valid for white (Caucasian) men of
European descent at this time. The genetic markers used in
the test have not yet been thoroughly tested in other ethnic
groups.
No. Your genetic risk does not change over time.
This genetic test helps determine a man’s chances of
developing prostate cancer (women are not at risk for
prostate cancer as they do not have prostate glands). The
average risk for a Caucasian man in the United States to
develop prostate cancer during his lifetime is 16 percent.
Many factors, including family history of prostate cancer,
ethnicity, age, and genetic susceptibility, mean some men
have a higher or lower than average risk.
Can this test tell me if I have prostate cancer or will
develop prostate cancer?
No. This test cannot diagnose or confirm prostate cancer. This
test estimates your chances of developing prostate cancer
based on 27 DNA markers. A high risk result does not mean
you currently have, or will develop, prostate cancer. A low risk
result does not mean you will never develop prostate cancer.
Other risk factors not included in this test (e.g., age, family
history, etc.), may further increase or decrease your risk for
prostate cancer.
Can I directly order this test?
No. Your doctor must order the test, and you will receive your
results through your doctor. The benefits and limitations of the
test and the interpretation of test results are best explained
through counseling with your doctor, a certified genetic
counselor, or other qualified healthcare professional.
What does the test measure?
The test measures 27 common DNA markers (SNPs) and their
associated risk for prostate cancer. Additional genetic risk
factors for prostate cancer may be identified in the future
and are not currently included in this test; however, this test
examines many common DNA markers now known to be
associated with risk for prostate cancer.
This test assesses genetic risk for prostate cancer only and has
no relationship to the deCODEme™ genetic scan products
offered by deCODE Genetics that assess genetic contribution
for multiple disorders/traits.
Will I need to have my blood drawn for this test?
Your genetic risk for prostate cancer is determined using the
27 identified markers. It is possible, however, that additional
risk markers for prostate cancer may be identified in the
future. Discovery of additional relevant markers could
potentially increase or decrease your genetic risk.
Know Your Risk and Adhere to Your
Doctor’s Screening Recommendations
Risk Factors:
• Age: Prostate cancer is rare before the age of 45, with 65
percent of cases diagnosed after the age of 65.
• Family history: Having a father or a brother with earlyonset prostate cancer (before age 65) doubles your risk,
and having two or more close relatives with early-onset
prostate cancer quadruples your risk.
No. This test is performed using DNA taken from cells gathered
by a swab of your cheek. The cheek cells are collected using
special brushes that gently scrape the inside the mouth.
• Ethnicity: African-American men are 1.6 times more likely
to develop prostate cancer than Caucasian (white)
males.
How long will it take to get results?
• Increased risk: Men with increased risk may benefit from
earlier and more frequent screening, including further PSA
testing and an ultrasound and/or biopsy when indicated.
Test results are usually available within three weeks after the
test is ordered.
How will the results of this test be used?
Your physician may use your test results (personalized genetic
information) to help determine the frequency and type of
medical screening for prostate cancer that will be most
beneficial for you.