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THE CANCER COUNCIL VIC Fellowships Carden Fellowship D Metcalf Walter and Eliza Hall Institute of Medical Research Regulatory control of normal and leukaemic cells $200,000 Colebatch Fellowship K Phillips Peter MacCallum Cancer Centre Reducing the burden of breast cancer $144,500 Dunlop Fellowship G McArthur Peter MacCallum Cancer Centre Development of targeted therapies for cancer $144,500 Lions Fellowship B Anderson Walter and Eliza Hall Institute of Medical Research Coeliac disease and increased risk of cancer – novel therapeutic approaches $20,000 (approx) Early Career Clinical Research Fellowship K Herbert Peter MacCallum Cancer Centre The use of novel therapies in haematopoietic stem cell transplantation in cancer $50,000 Total fellowships $559,000 Research grants R Anderson, I Haviv, J George Peter MacCallum Cancer Centre Functional genomic screen for metastasis suppressor genes controlling breast cancer metastasis to bone and lung $100,000 Y Antill, I Winship, M Jenkins Peter MacCallum Cancer Centre Studies into gynaecological cancers associated with the syndrome: Hereditary Nonpolyposis Colon Cancer $55,025 L Bach, G Rice Monash University Insulin-like growth factor (IGF)-dependent and -independent actions of IGF binding protein-6 $70,000 O Bernard St Vincent's Institute of Medical Research The role of LIM kinase 2 (LIMK2) in cancer metastasis $93,500 P Bouillet, G Belz Walter and Eliza Hall Institute Mouse models to study the function of the BH3-only members of the Bcl-2 family $100,000 W Chen Ludwig Institute for Cancer Research Study immunodominance of natural and induced anti-NY-ESO-1 T cell responses to optimize future cancer vaccine strategies $70,000 C Christophi, P Angus, V Muralidharan The University of Melbourne The Renin Angiotensin System and colorectal liver metastases $66,875 P Darcy, M Kershaw, J Trapani Peter MacCallum Cancer Centre Immunotherapy of Lewis Y+ malignancy using genetically engineered T cells $70,000 L Ebert Ludwig Institute for Cancer Research The role of regulatory T cells in suppression of immune responses in cancer vaccine recipients $65,000 W Fairlie, D Huang Walter and Eliza Hall Institute Understanding apoptosis through selective targeting of pro-survival proteins $70,000 G Fogarty (NSW), B Burmeister (QLD), K Drummond (VIC), A Nowak (WA), A Rezo (ACT), J Thompson (NSW), J Simes (NSW) Whole brain radiotherapy following local treatment of intracranial metastases of melanoma – a randomised phase III trial M Friedlander (NSW), P Grimison (NSW), M Stockler (NSW), G Toner (VIC), D Thomson (QLD), N Singhal (SA) Accelerated first line chemotherapy for advanced germ cell tumours $11,250 P Fuller Prince Henry's Institute of Medical Research Characterisation of the molecular pathogenesis of ovarian granulosa cell tumours $70,000 C Gargett Monash University Identifying markers of stem/progenitor cells in normal and malignant endometrium $100,000 M Gillespie St Vincent's Institute of Medical Research Role of parathyroid hormone-related protein in DNA repair and breast cancer susceptibility to TRAIL-mediated apoptosis $100,000 C Hawkins, D Ashley & H Friedman Murdoch Childrens Institute Factors influencing TRAIL sensitivity in ex vivo malignant glioma $70,000 P Humbert Peter MacCallum Cancer Centre The role of scribble in mammalian tumour development $68,652 B Jenkins, A Mansell, R Ferrero Monash University Cross-talk between cytokine and pathogen recognition receptor networks in the pathogenesis of gastric cancer $98,900 $8,500 R Johnstone Peter MacCallum Cancer Centre Mechanisms of action of histone deacetylase inhibitors: novel anti-cancer drugs $70,000 A Kneebone (NSW), S Williams (VIC), G Duchesne (VIC), R Fisher (VIC), M Frydenberg (VIC) A phase III trial comparing adjuvant versus salvage radiotherapy for high risk patients post radical prostatectomy G Lindeman (Vic), G Mitchell (Vic), A Stapleton (SA) The University of Melbourne Identification of men with a genetic predisposition to prostate cancer and their clinical treatment – The IMPACT Study $63,300 J McCluskey, Dr J Rossjohn University of Melbourne The structural and functional basis of tumour recognition by NKT cells $70,000 M McKay, H Xu Peter MacCallum Cancer Centre Cohesin-mediated modulation of mammalian radiosensitivity E Nice, P Gibbs, L Lipton Ludwig Institute for Cancer Research Development of validated biomarker assays for the early detection and surveillance of colon cancer R Pearson Peter MacCallum Cancer Centre Mechanisms of AKT3 driven malignant transformation G Pietersz Macfarlane Burnet Institute for Medical Research and Public Health Cell penetrating peptide-mediated delivery of multiple CD8 and CD4 T cell Epitopes for breast cancer vaccines $100,000 $100,000 $70,000 $100,000 $92,346 T Price (SA), J Harvey (QLD), N Tebbutt (VIC), Preop chemoradiotherapy&postop chemo with capecitabine & oxaliplatin G Hruby (NSW), S Bydder (WA), vs capecitabine alone in locally advanced rectal cancer R Simes (NSW), J Zalcberg (VIC) $24,500 R Ramsay, I Bertoncello, E Stanley Peter MacCallum Cancer Centre CSF-1 is an essential intestinal epithelial cell mitogen $70,000 G Risbridger, S McPherson Monash Institute of Medical Research Early origins of prostate cancer $66,000 S Russell, H Richardson Peter MacCallum Cancer Centre A new role for polarity proteins in leukemia/lymphoma $70,000 B Sarcevic St Vincent's Institute of Medical Research Identification of SAP180 and RBP1 as novel CDK substrates important for regulation of the pRb tumour suppressor $100,000 A Shulkes, J Ischia, G Baldwin, D Bolton University of Melbourne ProGRP as a biomarker for prostate cancer $100,000 M Smyth Peter MacCallum Cancer Centre Combined chemo-immunotherapies that eradicate established tumors $100,000 M Southey University of Melbourne New gene for BRCA1-like early-onset breast cancer $97,500 D Thomas, P Simmons Peter MacCallum Cancer Centre Role of WIF1 in bone development and oncogenesis $70,000 P Thompson, B Vogelstein Monash University Towards selective inhibition of oncogenic forms of PI3K – a chemical biology approach $66,750 E Thompson, A Dobrovic, P Choong, P Hill, M Henderson, K Pantel University of Melbourne Epithelial – mesenchymal interconversions in the breast cancer metastatic cascade $95,100 T Tiganis Monash University Regulation of the Src proto-oncogene $70,000 P Vasey (NSW), M Quinn (Vic), J Simes (NSW), M Friedlander (NSW), M Buck (Qld), B Koczwara (SA) Royal Women's Hospital Carboplatin flat dosing versus intrapatient dose escalation in first line chemotherapy of ovarian cancer $38,000 N Wetzig (Qld), G Gill (SA), O Ung (NSW), J Collins (Vic), D Oliver (WA) Royal Melbourne Hospital SNAC2: A randomised trial of extending sentinel node based management to women with larger or multifocal breast cancers $30,000 E Williams, K Opeskin, C Temelcos Monash Institute of Medical Research Mechanisms underlying prostate cancer lymph node metastasis $70,000 L Wu Walter and Eliza Hall Institute Development and functional analysis of human dendritic cell subsets $70,000 Total reseach grants $3,091,198 Venture grants The Venture Grants Scheme is an initiative designed to fund projects that push the conventional boundaries. Successful projects were selected via a competitive application process and their continued funding is dependent on key milestones being met. The Cancer Council Victoria provided seed funding and funding for future milestones is still being sought. W Alexander, B Kile, A Strasser Walter and Eliza Hall Institute Scanning the genome for new drug targets in cancer $159,562 A Brumby, P Humbert, H Richardson, I Street Drosophila as a novel tool for anti-cancer drug discovery University of Melbourne $44,747 R Johnstone, R Hannan, G McArthur, R Pearson Peter MacCallum Cancer Centre Identification of novel breast cancer suppressor and chemotherapeutic drug sensitivity genes using shRNA-mediated functional genomics screens $317,000 P Rogers, R Lewis, I Svalbe, B Williams, D Blakey Monash University The biological effects of synchrotron microbeam radiation therapy on normal and tumour tissues $129,125 J Visvader, I Street, G Lindeman, K Watson, M Asselin-Labat Walter and Eliza Hall Institute Developing lead compounds to target breast cancer by specific inhibition of the LMO4-oncogene Total venture grants $35,187 $685,621 Postdoctoral research fellowships E Lee, Walter & Eliza Hall Institute of Medical Research $63,500 M Moeller, Peter MacCallum Cancer Centre $63,500 P Kelly, Walter & Eliza Hall Institute of Medical Research $31,750 M van Delft, Walter & Eliza Hall Institute of Medical Research $31,750 Two fellowships to be appointed mid-year $64,750 Total postdoctoral research fellowships $255,250 Postgraduate research scholarships S Amos, Peter MacCallum Cancer Centre F Barnett, Ludwig Institute for Cancer Research $23,558 $2396 I Elsum, Peter MacCallum Cancer Centre $23,150 C Fedele, Monash University $11,987 Y Jayasinghe, Murdoch Children's Research Institute $28,250 D Kethesparan, Monash University $23,150 S Lee, Ludwig Institute for Cancer Research $28,250 E Naik, Walter & Eliza Hall Institute of Medical Research $9989 N Thomas, Monash University $23,558 Four postgraduate scholarships to commence January 2008 $96,000 Total postgraduate research fellowship $270,288 Vacation studentships 25 six week summer Vacation Studentships were awarded Support for medical and scientific activities $35,300 $309,000 Clinical research The Cancer Council also supports clinical research via the Centre for Clinical Research in Cancer. The centre conducts state, national and international clinical trials initiated by and endorsed by the Victorian Cooperative Oncology Group. The Centre also administers the Cancer Trials Management Scheme, awarding grants totalling $800,000 to 20 hospital cancer clinics to assist clinicians to enrol patients in clinical trials. $1,765,000 Cancer Control Research Institute programs Cancer Epidemiology Centre $3,195,000 Victorian Cancer Registry $3,869,000 The Melbourne Collaborative Cohort Study (Health 2000) $2,977,000 Centre for Behavioural Research in Cancer $2,923,000 VicHealth Centre for Tobacco Control (Cancer Council Victoria contribution to VicHealth Centre) $2,192,000 Total Cancer Control Research Institute programs $15,156,000 TOTAL RESEARCH FUNDED $22,126,657