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Together we’re creating a future without breast cancer Report to the community 2014 highlights An unwavering vision A message from our National Board Chair Canadian Breast Cancer Foundation made a commitment more than 28 years ago to drive positive change by funding high-impact breast cancer research, education, and advocacy programs. Today we are proud to be the largest non-government funder of breast cancer research, with more than $300 million invested in grants and fellowships. In fiscal 2014, CBCF invested $27 million to fund projects and programs focused on advancing our mission. A significant portion – $17.5 million – was directed to breast cancer research and training grants; health promotion and education initiatives accounted for $5 million and the remainder was allocated to community development and other cause programs. Thanks to our generous donors and volunteers, we have the means to support the best and brightest researchers from across the country. They are working diligently to develop improved ways to diagnose and treat breast cancer, with fewer side effects, and minimize negative impact on quality of life. Recognizing the power of many, CBCF frequently collaborates with other groups. For example, this year we partnered with the Canadian Institutes of Health Research - Institute of Cancer Research (CIHR-ICR) to fund a research program specifically focused on breast cancer in young women, involving 62 researchers and clinicians at 44 institutions and clinics across the country. By staying true to the commitment we made almost three decades ago, CBCF is helping to advance the vision of a future without breast cancer – a vision we share with our supporters and with our partners in research, education and advocacy. We will continue to drive this vision today, tomorrow, for as long as it takes. Susan Ewanick Chair, National Board of Directors 2 Driving progress A message from our CEO and Ontario Board Chair In 2014, thanks to your generous support, we awarded $7.9 million in grants to fund 17 new breast cancer research projects and 10 new training fellowships in Ontario. The research projects range in focus from studying ways to prevent breast cancer to a two-step vaccine that would not only kill tumours but also help prevent them from coming back. With the remarkable support of CIBC and Shoppers Drug Mart, the Pink Tour visited more than 360 Ontario communities and connected with over 56,500 people in the last two years, providing valuable information about breast health and breast cancer screening. We also continued to advocate for and with the breast cancer community. The launch of ‘My Breast My Test’, a Facebook-based social site helped to raise awareness and reduce the confusion around the benefits and limitations of breast cancer screening and share valuable evidence-based information. We are making progress! Over the last 30 years there have been 43% fewer breast cancer deaths. Women are receiving more targeted and less invasive treatments with fewer side effects and better outcomes. But we can’t stop now. Breast cancer is a complex disease and we need to continue to invest so that fewer women experience a breast cancer diagnosis and those diagnosed can live long and healthy lives. Thank you for your commitment and generosity. Together we can create a future without breast cancer. Sandra Palmaro CEO, Ontario Region Christy Teasdale Chair, Ontario Region Board of Directors 3 Research Highlights See how far we’ve come From engineering cancer-killing designer viruses and harnessing the power of the immune system, to testing a safe and existing drug for a new use in breast cancer treatment, every breakthrough in research brings us closer to our goal of a future without this disease. Prevention Screening Treatment Quality of Life Enhancing results with early detection and screening 4 What today’s treatment innovations hold for the future Improving quality of life after breast cancer Visit our website for more videos and stories www.cbcf.org/oncommunityreport New discoveries in genetic markers Dr. Kristan Aronson Professor, Queen’s University & Member, Division of Cancer Care & Epidemiology, Cancer Research Institute 5 PREVENTION Innovative drugs could cool hot flashes without increasing risk of breast cancer SCREENING Computer taught to identify breast cancer can improve early detection and reduce false positives “We are taking thousands of archived images from diagnosed breast cancer cases and putting them through algorithms that will basically allow the computer to learn the particular features of breast cancer,” explains Dr. Anne Martel, the senior scientist leading the project. “So when it sees a new sample, it can predict the probability of breast cancer based on what it learned from the previous images.” 6 CBCF-funded researchers in Ottawa are developing drugs that can help women struggling with menopause symptoms without increasing their risk of breast cancer. Dr. James Wright at Carleton University and Drs. Christine Pratt and Tony Durst at the University of Ottawa have produced drug compounds that mimic natural estrogen to reduce hot flashes without activating the estrogen receptors believed to cause breast cancer. QUALITY OF LIFE Mindfulness program could ease nerve-related pain for women living with breast cancer Chronic pain from a damaged nervous system affects half of all breast cancer patients. University of Ottawa researchers are studying the effect of mindfulness based stress reduction on qualify of life, mood and physical function. (Dr. Patricia Poulin) TREATMENT Canadian-led study looks at diabetes drug as breast cancer treatment The $20-million global study could soon give women with breast cancer access to metformin, a low-cost drug with few side effects that can improve their chances of survival. (Dr. Wendy Parulekar) 7 SCREENING SCREENING Imaging markers Imaging markerscan savesave moremore lives by can lives making cancer cells by making cancer easy to spot cells easy to spot Led by by Dr. Dr. Francois Francois Bénard Bénard at at the the Led B.C. Cancer Agency in Vancouver, B.C. Cancer Agency in Vancouver, this research research group group is is focusing focusing on on this next-generation imaging markers next-generation imaging markers –– also known known as as radiotracers radiotracers –– that that also target somatostatin receptors target somatostatin receptors present in in almost almost all all breast breast cancers. present The markers bind to the receptors, cancers. The markers bind to the essentially labelling them so they’re receptors, essentially labelling them visible on avisible scan.on a scan. so they’re QUALITY OF LIFE Study of memory functions aims to improve life after breast cancer CBCF-funded researchers have found that women with breast cancer were five times more likely than healthy women to have problems remembering future tasks. The researchers have launched a new study to determine a possible connection between chemotherapy, impaired prospective memory and fatigue. (Dr. Lise Paquet) 8 TREATMENT Engineered white blood cells could boost survival rates for women with metastatic breast cancer Dr. Jonathan Bramson has embarked on research into white blood cells engineered to detect and attack breast cancer cells. This innovative approach involves taking white blood cells from the patient and equipping the cells with feelers that can recognize breast cancer. These engineered cells are then injected back into the patient. TREATMENT Viral vaccine could halt the return of breast cancer cells Dr. Brian Lichty and his team began their work with the Maraba virus, a powerful fighter of tumour cells. Adding a second virus resulted in a mix that could also train the immune system to identify and attack cancer cells, preventing a relapse. 9 Living and giving for a future without breast cancer Olga Weatherdon Providing Inspiration There seems to be no stopping this 71-year-old. With help from her husband and friends, Olga is busy handmaking knitted items, baked goods and lemonade so she can sell them and raise funds for breast cancer research. What keeps Olga going? She was diagnosed with breast cancer in 2010 and has spent the last four years celebrating life in remission. Olga: Middle Alicia Tait Personal Insights for a Big Vision At the age of 26 - just three years after she learned she had cancer, Alicia shared her experience with a group of funders and researchers taking part in a Breast Cancer in Young Women workshop, hosted by CBCF and the CIHRICR. The insights from the workshop led to a $5.7-million cross-Canada program that brings together researchers from different disciplines to study breast cancer in women 40 years and under. Alicia: Middle 10 Winnie Go A Role Model When the doctor confirmed she had breast cancer and that it had spread to her lymph nodes, friends and family naturally expected Winnie to focus on her personal care and treatment. But Winnie decided that while she needed to take care of herself, it was equally important for her to do as much as she could for others facing a similar battle. Bolstered by this conviction, Winnie threw a party and cut off her hair, donating it to children with cancer. She also raised over $8,000 for the Wig Salon. 11 Denise Deacey Best Friend Ever Denise Deacey is a power fundraiser for the Canadian Breast Cancer Foundation CIBC Run for the Cure. But Denise has not been diagnosed with the disease and does not know of relatives with breast cancer. So why is she doing so much in the name of breast cancer research? “Two of my girlfriends were diagnosed with breast cancer five weeks apart,” says Denise, who launched a Circle of Friends Golf Tournament for her friends. To celebrate her 10-year milestone as a supporter and power fundraiser for breast cancer research, Denise has set a goal of raising her fundraising total to $200,000 in 2015. Denise: Right 12 Jackie Barr Determined Spirit Diagnosed in 1997 with breast cancer, and again in 2006, Jackie is now living with Stage 4 cancer. Despite the diagnosis, none of this has stopped Jackie from being Jackie. Those who know Jackie and her determined spirit would not be surprised to learn that she decided to participate in the Canadian Breast Cancer Foundation CIBC Run for the Cure the same year she received her first diagnosis. In the 17 years that Jackie has been living with the disease, she has raised over $60,000 for breast cancer research. Jackie: Right 13 Taking steps toward a future without breast cancer On October 6, 2013, more than 57,000 Ontarians from 30 communities across the province came together to walk or run for a hopeful future – a future without breast cancer. The result: $12.1 million raised in Ontario and $27 million nationwide for breast cancer research. With every step, stride and sprint, we’re moving closer to a future without breast cancer. “Let’s not stop now,” says Christina Kramer, Executive Vice President, CIBC and the bank’s Executive Run Sponsor. “While progress has been made, breast cancer continues to be the most common diagnosis for Canadian women.” 14 Education & Advocacy Sharing the knowledge The more you know about breast cancer, the easier it is to make informed decisions that affect your health and the wellbeing of your family. As Canada’s largest non-government funder of breast cancer research, Canadian Breast Cancer Foundation is always tapped into the latest findings – from reducing the risks for breast cancer to early detection and treatment options. We share these important findings with Canadian women and health care providers through educational materials and programs that address key focus areas. The Pink Tour Breast cancer education hit the road in the summer of 2012 and 2013, when the 46-foot Pink Tour bus pulled up at 360 stops in communities across Ontario and connected with more than 56,000 residents. Breast Health Did you know that one-third of breast cancers are preventable? To help Canadian women maintain healthy breasts and make lifestyle changes and decisions that reduce the risk of breast cancer, CBCF launched a Breast Health Program in January 2013. By its second year, the Breast Health Program had built a community of more than 15,000 social media followers, and boasted over 22,000 visits to its inspiring cbcf.org/onenewthing website. My Breast My Test Canadian Breast Cancer Foundation launched My Breast My Test, a Facebook-based advocacy program that gives women access to accurate, evidence-based information about the benefits and limitations of breast screening so they can make informed decisions. This site also lets them share their questions, concerns and experiences with other women. In just over a month since it went live in April 2014, My Breast My Test received more than 2,200 likes and hundreds of testimonials from women about their experiences surrounding screening. 15 Fellowships Funding specialized training to build strong teams To build strong teams focused on improving breast cancer treatment and care, we need to support specialized training for researchers and health care professionals. Canadian Breast Cancer Foundation held a fellowship competition in partnership with TELUS, which provided $400,000 to fund five fellowships in 2013. Congratulations to the TELUS-Canadian Breast Cancer Foundation National Fellowship recipients! Dr. Julie Arsenault, McMaster University, Hamilton: Evaluating a robotic radiosurgery device for use in breast-conserving surgery Dr. Julie Arsenault was among the five fellows who received funding for research ranging from examining the rehabilitation needs of women with breast cancer to understanding the role of microenvironments in targeted therapies. A radiation oncologist from Hamilton, Dr. Arsenault will study a robotic radiosurgery device called Cyberknife, to see if it’s safe and effective for surgery to treat early-stage breast cancer. Dr. Ling-l Olivia Tseng, BC Cancer Agency, Vancouver: Investigating how interactions with family physicians can improve care for people with breast cancer Karen Dobbin, Cancer Care Manitoba/University of Manitoba, Winnipeg: Examining the rehabilitation needs of women with breast cancer Dr. Saima Hassan, Dr. Sami Benzina, Centre hospitalier de l’Université de Montreal, Montreal: Understanding the molecular signatures that can help predict treatment outcomes based on cancer subtype 16 University of Moncton, Moncton: Studying the role of a gene that could affect the spread of breast cancer Financial Summary* Year ended March 31, 2014 Sources of funding CBCF CIBC Run for the Cure 66% Corporate Partnerships 12% Community Events 7% Individual Donors 4% Direct Marketing 4% Special Events 1% Government Partnerships 2% Other 4% How funds are spent Grants ** 69% Health Promotion & Education 26% Grant Review & Administration 3% Volunteer Development 2% * These statements reflect an unaudited financial summary of Ontario Region only. The Canadian Breast Cancer Foundation (CBCF) is audited on a national basis. For audited national financial statements please visit www.cbcf.org ** Grants are presented net of returned funds from previous years’ grants 17 We can’t stop now Thank you You make it all possible Canadian Breast Cancer Foundation Ontario Region 20 Victoria Street, 6th Floor Toronto, ON M5C 2N8 Visit our website: www.cbcf.org/ontario See us on YouTube: youtube.com/cbcfontario Friend us on Facebook: facebook.com/cbcfontario Follow us on Twitter: @CBCF_Ontario On the cover: Kathy Phillips got involved with Canadian Breast Cancer Foundation in 2011 when she participated in the Canadian Breast Cancer Foundation CIBC Run for the Cure on behalf of her aunt. Just six months later, Kathy was diagnosed with breast cancer. Thanks to the most innovative care and treatment, Kathy is thriving. ™ Trademark of the Canadian Breast Cancer Foundation, used under license.