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5th SYMPOSIUM ON THE NEUROVIROLOGY AND NEUROIMMUNOLOGY OF SCHIZOPHRENIA AND BIPOLAR DISORDER NOVEMBER 4-6, 1999 RETROVIRAL SEQUENCES IDENTIFIED IN THE CEREBROSPINAL FLUIDS OF INDIVIDUALS WITH RECENT ONSET SCHIZOPHRENIA Håkan Karlsson, Department of Neuroscience, Karolinska Institute, Sweden II. IN VITRO ANALYSIS OF CEREBROSPINAL FLUIDS FROM CASES OF FIRST-BREAK PSYCHOSES Lorraine Jones- Brando, Johns Hopkins University, Stanley Division of Developmental Neurovirology, Baltimore, MD DIFFERENTIAL RNA EXPRESION IN A CELL LINE COCULTURED WITH CSF OF A SCHIZOPHRENIC PATIENT Dunja Hinze-Selch, Johns Hopkins University, Stanley Division of Developmental Neurovirology, Baltimore, MD REVERSE TRANSCRIPTASE (RT) ACTIVITY IN CLNICAL AND POSTMORTEM SAMPLES OBTAINED FROM INDIVIDUALS WITH SCHIZOPHRENIA Frances Yee, Johns Hopkins University, Stanley Division of Developmental Neurovirology, Baltimore, MD PROPERTIES OF LINE-1 ELEMENTS IN GENOMIC DNA FROM DIFFERENT REGIONS OF THE HUMAN BRAIN Christine Miller, Johns Hopkins University, Stanley Division of Developmental Neurovirology, Baltimore, MD ALTERATIONS IN THE EXPRESSION OF PHOSPHORYLATED GLIAL FIBRILLARY ACIDIC PROTEINS IN THE FRONTAL CORTEX OF INDIVIDUALS WITH SCHIZOPHRENIA, BIPOLAR DISORDER AND DEPRESSION Maree Webster, Stanley Laboratory of Brain Research, Bethesda, MD IMMUNOLOGIC AND GLUTAMATERIGIC-CHOLINERGIC CHARACTERISTICS OF THE LATERAL CEREBELLUM IN SCHIZOPHRENIA PATIENTS Linda D. Bobo, Johns Hopkins University, Stanley Division of Developmental Neurovirology, Baltimore, MD UPDATE ON THE STANLEY FOUNDATION NEUROPATHOLOGY CONSORTIUM: FOCUS ON THE PREFRONTAL CORTEX Michael B. Knable, Stanley Foundation, Bethesda, MD MATERNAL INFECTIONS AND SUBSEQUENT PSYCHOSES AMONG OFFSPRINGS: A FORTY YEAR PROSPECTIVE STUDY Stephen Buka, Harvard University School of Public Health, Boston, MA PATHWAYS TO ADULTHOOD: A THIRTY-YEAR, INTERGENERATIONAL STUDY OF CHILDREN BORN TO INNER-CITY MOTHERS Janet B. Hardy, Johns Hopkins University, Baltimore, MD A LONGITUDINAL STUDY OF BIRTH RISKS, MOTHER’S BEHAVIORS TOWARD THE INFANT AT 4 & 8 MONTHS, AND MENTAL CONDITIONS IN ADULTHOOD Angela Fan, Johns Hopkins University, Baltimore, MD PRENATAL RUBELLA, PREMORBID I.Q., AND ADULT SCHIZOPHRENIA SPECTRUM DISORDERS Alan S. Brown, Columbia University, New York, NY POLYCHLORINATED BIPHENYL EXPOSURE IN UTERO AND SUBSEQUENT NEURODEVELOPMENT: EXPERIENCE FROM THE COLLABORATIVE PERINATAL PROJECT (CPP) Matthew P. Longnecker, NIEHS, Epidemiology Branch, Research Triangle Park, NC IMPACT OF HERPES SIMPLEX VIRUSES (HSV) ON THE FETAL AND NEONATAL BRAIN Andre Nahmias, Emory University School of Medicine, Atlanta, GA PRELIMINARY EVALUATION OF VIRUSES AND INTRACELLULAR BACTERIA STATUS IN URBAN CATS AND THEIR RELATIONSHIP WITH DEVELOPMENT OF SCHIZOPHRENIA IN HUMAN Reza Firouzi, Stanley Foundation (Deficits Immunitaire), France VITERIA: ANIMAL VIRUSES WITH INCORPORATED BACTERIAL GENETIC SEQUENCES W. John Martin, Center for Complex Infectious Diseases, Rosemead, CA DO BACTERIA AND PARASITES CAUSE MENTAL ILLNESS? Robert Bransfield, Red Bank, NJ DISCOVERY OF POTENTIAL BIOMARKERS FOR SCHIZOPHRENIA USING SELDI PROTEINCHIP TECHNOLOGY Joseph J. Breen, Ciphergen Biosystems, Inc., Rockville, MD CORPUS CALLOSUM CHANGES AND DURATION OF UNTREATED PSYCHOSIS IN FIRST-EPISODE SCHIZOPHRENIC PATIENTS Silke Bachman, University of Heidelberg, Germany CEREBELLAR VOLUME CHANGES AND DURATION OF UNTREATD PSYCHOSIS IS FIRST-EPISODE SCHIZOPHRENIC PATIENTS Silke Bachman, University of Heidelberg, Germany ISOLATION OF DIFFERENTIALLY EXPRESSED GENES IN SCHIZOPHRENIA Maja Schramm, Bonn Medical Center, Germany ANTIBODIES AGAINST HIV-1 INDUCE NEURONAL APOPTOSIS: A POSSIBLE MECHANISM FOR PATHOGENESIS OF AIDS DEMENTIA COMPLEX Nathalie Goletiani, Harvard University, Boston, MA RETROELEMENTS AS POTENTIAL PATHOGENS IN NEUROPSYCHIATRIC DISEASES Heui-Soo Kim, Pusan National University, Korea HUMAN CORONAVIRUS 229E PRODUCTIVELY INFECTS PERIPHERAL BLOOD-DERIVED MNOCYTE/MACROPHAGES AND INDUCES APOPTOSIS Arlene Collins, State University of New York at Buffalo, Buffalo, NY ACTIVATION OF HHV-6 AND UP-REGULATION OF 2’5’-A-BINDING PROTEINS IN PATIENTS WITH MULTIPLE SCLEROSIS Dharam V. Ablashi, Advanced Biotechnologies Inc., Columbia, MD ABSENCE OF SPIROPLASMA OR OTHER BACTERIAL DNA IN SUFFICIENT TO ACCOUNT FOR THE HIGH LEVELS OF INFECTIVITY IN HAMSTER BRAINS INFECTED WITH THE 263K STRAIN OF SCRAPIE Irina Alexeeva, Baltimore Research and Education Foundation, Baltimore, MD THE THALAMIC MIDLINE NUCLEI: A NEGLECTED LIMBIC RELAY Marina Bentivoglio, University of Verona, Italy QUINOLINIC ACID AND NEOPTERIN IN CHILDREN WITH AUTISM: AN ANALYSIS OF CEROBROSPINAL FLUID Andrew W. Zimmerman, Kennedy Krieger Institute, Baltimore, MD MOLECULAR HINTS FOR A TWO-HIT MODEL OF SCHIZOPHRENIA Thomas Bayer, University Bonn Medical Center, Germany ANALYSIS OF GENE EXPRESSION IN HUMAN BRAINS USING HIGH DENSITY cDNA MICROARRAY Jonathan Pevsner, Kennedy Krieger Institute, Baltimore, MD NEUROTROPHIC AND NEUROPROTECTIVE EFFECTS OF MOOD STABILIZING AGENTS: IMPLICATIONS FOR THE LONG TERM TREATMENT OF MANIC-DEPRESSIVE ILLNESS Husseini K. Manji, Wayne State University School of Medicine, Detroit, MI FRAGILE SITES—FRAGILE MINDS Cassandra Smith, Boston University, Boston, MA THE STATUS OF LINKAGE TO CHROMOSOMAL DNA SEQUENCES IN PSYCHOSIS AND ALTERNATIVE MECHANISMS FOR THE INHERITANCE OF SCHIZOPHRENIA Lynn E. DeLisi, Department of Psychiatry, Stony Brook, NY AETIOLOGY OF SCHIZOPHRENIA AS EPIGENETIC RATHER THAN GENETIC Timothy J. Crow, University Dept of Psychiatry, Warneford Hospital, UK INCREASED GFAP-IMMUNOREACTIVITY AND ASTROGLIOSIS IN CORTEX AND HIPPOCAMPUS OF DEVELOPING MICE FOLLOWING HUMAN INFLUENZA VIRAL INFECTION IN UTERO S. H. Fatemi, University of Minnesota Medical School, Minneapolis, MN SEROLOGIC EVIDENCE FOR A RETROVIRUS/HSV-2 ASSOCIATION WITH SCHIZOPHRENIA Erik Lillehoj, Roveko Ltd, Gaithersburg, MD EVOLUTION OF LIVE-ATTENUATED HIV-1 VACCINES Ben Berkhout, University of Amsterdam, The Netherlands I1-1B AND TNFa DECREASE EMBRYONIC CORTICAL NEURON SURVIVAL John Gilmore, UNC School of Medicine, Chapel Hill, NC OLIGOCLONAL T CELLS ARE PRESENT IN THE CSF OF A PATIENT WITH MS-DEMYELINATING DISEASE FOLLOWING HEPATITIS A INFECTION Emilia Oleszak, Temple University School of Medicine, Philadelphia, PA TOWARDS AN ANIMAL MODEL FOR THE AUTOIMMUNE THEORY OF MENTAL DISORDERS Boris Sakic, McMaster University, Ontario, Canada INTERLEUKIN-2 STIMULATES EXPLORATORY ACTIVITY AND INCREASES SENSITIVITY TO THE STIMULATORY EFFECTS OF A SELECTIVE DOPAMINE UPTAKE INHIBITOR Steve Zalcman, UMD-New Jersey Medical School, Newark, NJ INTERFERON-GAMMA RECEPTORS IN THE RAT NERVOUS SYSTEM:TOPOGRAPHIC DISTRIBUTION AND EFFECTS OF ACTIVATION Krister Kristensson, Karolinska Institutet, Stockholm, Sweden DIFFERENT IMMUNE PATTERNS IN MELANCHOLIC AND NONMELANCHOLIC MAJOR DEPRESSION Mathias Rothermundt, University of Muenster, Germany BORNA DISEASE VIRUS AND HUMAN DISEASE: THE CONUNDRUM Kathryn M. Carbone, DVP.OVER/CBER/FDA, Bethesda, MD THERAPY RESISTANT, PROBABLY BORNA-DISEAES-VIRUSENCEPHALITIS-RELATED, PSYCHOSES IMPROVED BY CEREBROSPINAL FLUID FILTRATION Karl Bechter, University of Ulm, Germany NEONATAL BORNA VIRUS INFECTIN OF THE RAT BRAIN IS A NEW ANIMAL MODEL FOR DEVELOPMENTAL BEHAVIRORAL DISORDER M. Pletnikov AN INFECTION-BASED MODEL OF NEURODEVELOPMENTAL DAMAGE M. Hornig DURATION OF UNTREATED PSYCHOSIS AND TREATMENT RESPONSE IN FIRST-EPISODE SCHIZOPHRENIC PATIENTS Silke Bachmann, University of Heidelberg, Germany WHAT ARE THE CAUSES OF URBAN-RURAL DIFFERENCES IN SCHIZOPHRENIA RISK? Preban Bo Mortensen, European Stanley Research Center, Denmark