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Peter Sykes ANZGOG 2013 Modest Contribution to International Gyn oncology Research International multicentre trials NZ multicentre trials Laboratory research Commercial research. ANZGOG trials Other International collaborative trials LACE (Univ of Queensland) (chch) Chorus(MRC) (chch) Novartis Phase 2 trial of dovitinib in metastatic endometrial cancer. This group of patients have progressed after one line of chemotherapy and stratifies according to FGFR2 mutational status. PI Peter Fong TRINOVA-2: Amgen sponsored Phase 3 trial of PLD vs PLD plus AMG386 in relapsed platinum resistant ovarian cancer. PI peter Fong NZ Publications 2011,2012. Over 40 publications Otago Univ from NZ researchers ADIS international Drug evaluation Auckland univ. Drug delivery(pro drugs), tumour biology, granulosa cell tumours. Aukland hospital. Vulval cancer. Cervical cancer. (DN WEL CHCH) tumour biology, Palliative care, epidemiology, inequality Victoria university, Tumour biology Massey university, epidemiology, inequality Waikato hospital HDR physics NZ HPV (GSK) study Women 18 years of age with ICC stage 1B or higher diagnosed between 2004 and 2010. paraffin embedded specimens where consent from the patient (or her next of kin if she was deceased) could be obtained. Demographic details were recorded. Cervical specimens underwent histopathological review and HPV DNA detection (DDL Diagnostic Laboratory, the Netherlands). PREVALENCE AND TYPE DISTRIBUTION OF HUMAN PAPILLOMAVIRUS (HPV) IN 242 NEW ZEALAND WOMEN WITH INVASIVE CERVICAL CANCER 100 Percentage of all confirmed ICC cases 90 80 70 60 50 40 30 20 10 0 <30 years N=14 30-39 years N=53 40-49 years N=55 50-60 years N=40 >60 years N=65 Among NZ women with confirmed ICC, 88.5% were infected with HPV. HPV-16 and HPV-18 were the most frequently detected HPV types Similar to international data, types 31, 45, 52 and 33 were frequently detected non-16/18 types We observed a negative association between stage II disease (and higher) and infection with HPV-16/18 or with HPV-18 compared to other HPV types. Minor variation of non-HPV16/18 prevalence was observed between Maori and non-Maori women . Ongoing NZ Collaborations NZGCG Sentinel nodes in PRINCESS endometrial cancer? Ongoing ANZGOG trials Predicting regression in CIN2, 9 centers Australia and NZ audit of sentinel node biopsy in vulval carcinoma. NZ highlights Anzgog participation Significant research interest in gynae cancer Cooperative studies achieved Promising future