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Syllabus
neurobiology of feeding - 71162
Last update 03-07-2016
HU Credits: 2
Degree/Cycle: 2nd degree (Master)
Responsible Department: nutrition sciences
Academic year: 0
Semester: 2nd Semester
Teaching Languages: Hebrew
Campus: Rehovot
Course/Module Coordinator: Prof Oren Froy
Coordinator Email: [email protected]
Coordinator Office Hours: by email
Teaching Staff:
Prof Oren Froy
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Course/Module description:
The Organization of the Nervous System, The Cellular Components of the Nervous
System, Nerve Cells, Neuroglial Cells, Neural Circuits, The Subdivisions of the
Central Nervous System, The External Anatomy of the Brain: Some General Points,
The Lateral Surface of the Brain, The Dorsal and Ventral Surfaces of the Brain, The
Internal Anatomy of the Brain, The Internal Anatomy of the Cerebral Hemispheres
and Diencephalon
The Sympathetic Division of the Visceral Motor System, The Parasympathetic
Division of the Visceral Motor System, The Enteric Nervous System
Neurotransmitters, What Defines a Neurotransmitter?, Two Major Categories of
Neurotransmitters, Neurons Often Release More Than One Transmitter,
Neurotransmitter Synthesis, Packaging Neurotransmitters, Neurotransmitter
Release and Removal, Acetylcholine, Glutamate, GABA and Glycine, The Biogenic
Amines, The Biogenic Amines, ATP and Other Purines, Peptide Neurotransmitters,
Endocannabinoids, Neurotransmitter Receptors and Their Effects, Cholinergic
Receptors, Glutamate Receptors, GABA and Glycine Receptors, Serotonin
Receptors, Purinergic Receptors, Catecholamine Receptors, Peptide Receptors
Brain Metabolism, Circulation and Energy Metabolism of the Brain,
Blood—Brain—Cerebrospinal Fluid Barriers, Nutrition and Brain Function, Nutrition
and Functional Neurochemistry, Nutrition and Structural Aspects of the Brain,
Nutrition and Brain Development
Hypothalamic Organization, Functions of the Limbic System, Role of the
Ventromedial Hypothalamus in Feeding, Role of the Lateral Hypothalamus in
Feeding, Role of Limbic Areas in Feeding, The Arcuate Nucleus is a Key Node of
Hypothalamic Control of Energy Balance , Role of the Brain Stem in Feeding, Role of
the Dorsomedial Hypothalamus in Energy Balance
Feeding and Satiety Circuits, Melanocortin-4 Receptors Regulate Energy and
Glucose Homeostasis, The Lateral Hypothalamus Links Coordinated Food Intake
Control and Arousal, Central Nervous System Control Of Thermogenesis
Hormonal Regulators Of The Brain-Gut-Adipose Axis, Adipostatic Factors, Leptin Is
the Prototypical Regulator of Energy Homeostasis, Distribution of Leptin Receptors,
The Role of Insulin and Glucose in Regulating Energy Homeostasis, Insulin Action in
the Brain, Glucose Levels Are Sensed by Neurons in the Brain, POMC Neurons Sense
Changes in Glucose Concentration,
Satiety and Hunger Factors, Role of the Brain stem in Satiety/Hunger, Gut Peptides
Involved in Satiety and Hunger, Cholecystokinin, PYY, Ghrelin, PreproglucagonDerived Peptides, GLP-1 and GLP-1R Neurons in the Central Nervous System,
Amylin, Bariatric Surgery and the Role of the Gastrointestinal System in the Control
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of Energy Homeostasis
Cytokines And Energy Balance, Neuroendocrine-Immune Interactions, Mechanisms
of Cytokine Signaling in the Central Nervous System, Interaction of Cytokines with
the Circumventricular Organs, Interactions of Cytokines at the Barriers of the Brain:
The Requirement of Prostaglandins
Entry of Cytokines into the Brain, Brain Regions Involved in the Cytokine Response
Neuroendocrine Disorders of Energy Homeostasis, Leptin and Leptin Receptor
Deficiency in Humans, Obesity resulting from Defective Melanocortin Signaling,
Narcolepsy
Circadian Rhythms, Effect of the Biological Clock on Metabolism, Effect of Redox on
Circadian Rhythms, Projection from the SCN to Regions in Hypothalamus, Effect of
SCN on Energy Balance, Body Temperature and Wakefulness
Course/Module aims:
To understand the connection between the nervous system and nutrition and
metabolism.
Learning outcomes - On successful completion of this module, students should be
able to:
To understand the connection between the nervous system and nutrition and
metabolism.
Attendance requirements(%):
0
Teaching arrangement and method of instruction: Lectures
Course/Module Content:
The Organization of the Nervous System, The Cellular Components of the Nervous
System, Nerve Cells, Neuroglial Cells, Neural Circuits, The Subdivisions of the
Central Nervous System, The External Anatomy of the Brain: Some General Points,
The Lateral Surface of the Brain, The Dorsal and Ventral Surfaces of the Brain, The
Internal Anatomy of the Brain, The Internal Anatomy of the Cerebral Hemispheres
and Diencephalon
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Required Reading:
1) Basic Neurochemistry 7th ed.
2) Neuroscience – exploring the brain 3rd ed.
3) Fundamental Neuroscience 3rd ed.
4) Williams Textbook of Endocrinology 11th ed.
5) Reviews in the medical literature (Pubmed)
Additional Reading Material:
-
Course/Module evaluation:
End of year written/oral examination 100 %
Presentation 0 %
Participation in Tutorials 0 %
Project work 0 %
Assignments 0 %
Reports 0 %
Research project 0 %
Quizzes 0 %
Other 0 %
Additional information:
None
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