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Download Appendix 1: ICD9 and ICD10 codes used to identify CVD and heart
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Appendix 1: ICD9 and ICD10 codes used to identify CVD and heart failure hospitalisations International Classification of Diseases, version 10 Australian Modification (ICD-10 AM) 2nd edition codes used to identify a hospitalisation for CVD or heart failure between 1 July 2001 and 31 December 2006: ICD-10AM code 3270000 3270001 3270002 3270003 3270004 3270005 3270006 3270007 3270008 3270009 3270010 3270011 3270300 3270800 3270801 3270802 3270803 3271200 3271201 3271500 3271501 3271502 3271503 3271800 3271801 3273000 3273001 3273300 3273301 3273600 3273900 3274200 3274500 3274800 3275100 3275101 3275102 3275103 3275400 3275401 3275402 3275700 3275701 Description Carotid bypass using vein Carotid-carotid bypass using vein Carotid-subclavian bypass using vein Carotid-vertebral bypass using vein Aorto-subclavian-carotid bypass using vein Carotid bypass using synthetic material Carotid-carotid bypass using synthetic material Carotid-vertebral bypass using synthetic material Carotid-subclavian bypass using synthetic material Aorto-carotid bypass using synthetic material Aorto-carotid-brachial bypass using synthetic material Aorto-subclavian-carotid bypass using synthetic material Resection of carotid artery with re-anastomosis Aorto-femoral bypass using synthetic material Aorto-femoro-femoral bypass using synthetic material Aorto-iliac bypass using synthetic material Aorto-ilio-femoral bypass using synthetic material Ilio-femoral bypass using vein Ilio-femoral bypass using using synthetic material Subclavian-femoral bypass using synthetic material Subclavian-femoro-femoral bypass using synthetic material Axillo-femoral bypass using synthetic material Axillo-femoro-femoral bypass using synthetic material Ilio-femoral crossover bypass Femoro-femoral crossover bypass Mesenteric bypass using vein, single vessel Mesenteric bypass using synthetic material, single vessel Mesenteric bypass using vein, multiple vessels Mesenteric bypass using synthetic material, multiple vessels Other procedures on inferior mesenteric artery Femoral artery bypass using vein, above knee Femoral artery bypass using vein, below knee Femoral artery bypass using vein, to tibio-peroneal trunk, tibial or peroneal artery Femoral artery bypass using vein, within 5cm of ankle Femoral artery bypass using synthetic material, above knee Femoral artery bypass using synthetic material, below knee Femoral artery bypass using synthetic material, to tibio-peroneal trunk, tibial or peroneal artery Femoral artery bypass using synthetic material, within 5 cm of ankle Femoro-femoral bypass using composite graft Femoro-popliteal bypass using composite graft Femoral to tibial or peroneal artery bypass using composite graft Femoral artery sequential bypass using vein Femoral artery sequential bypass using synthetic material 3276300 3276301 3276302 3276303 3276305 3276306 3276307 3276308 3276309 3276310 3276311 3276312 3276313 3276314 3276316 3276317 3276318 3276319 3305000 3305500 3307500 3308000 3310000 3311200 3311500 3311800 3312100 3312400 3312700 3313000 3315100 3315400 3315700 3316000 3316300 3317800 3318100 3350000 3350600 3350601 3350900 3351200 3351500 3351501 3351800 3352100 3352400 3352700 3353000 Other arterial bypass using vein Other arterial bypass graft using synthetic material Subclavian-vertebral bypass using vein Subclavian-axillary bypass using vein What is this? Aorto-coeliac bypass using vein Aorto-femoro-popliteal bypass using vein Ilio-iliac bypass using vein Popliteal-tibial bypass using vein Aorto-subclavian bypass using synthetic material Subclavian-subclavian bypass using synthetic material Subclavian-vertebral bypass using synthetic material Subclavian-axillary bypass using synthetic material Axillo-axillary bypass using synthetic material Axillo-brachial bypass using synthetic material Aorto-coeliac bypass using synthetic material Aorto-femoro-popliteal bypass using synthetic material Ilio-iliac bypass using synthetic material Popliteal-tibial bypass using synthetic material Replacement of popliteal aneurysm using vein Replacement of popliteal aneurysm using synthetic graft Repair of aneurysm in neck Repair of intra-abdominal aneurysm Replacement of carotid artery aneurysm with graft Replacement of suprarenal abdominal aorta aneurysm with graft Replacement of infra-renal abdominal aortic aneurysm with tube graft Replacement of infra-renal abdominal aortic aneurysm with bifurcation graft to iliac arteries Replacement of infra-renal abdominal aortic aneursym with bifurcation graft to femoral arteries Replacement of iliac artery aneurysm with graft, unilateral Replacement of iliac artery aneurysm with graft, bilateral Excision and repair of visceral artery aneurysm with direct anastomosis Replacement of ruptured suprarenal abdominal aortic aneurysm with graft Replacement of ruptured infra-renal abdominal aortic aneurysm with tube graft Replacement of ruptured infra-renal aortic aneurysm with bifurcation graft to iliac arteries Replacement of ruptured infra-renal abdominal aortic aneurysm with bifurcation graft to femoral arteries Replacement of ruptured iliac artery aneurysm with graft Repair of ruptured aneurysm in neck Repair of ruptured intra-abdominal aneurysm Carotid endarterectomy Innominate endarterectomy Subclavian endarterectomy Aorta endarterectomy Aorto-iliac endarterectomy Aorto-femoral endarterectomy Ilio-femoral endarterectomy, bilateral Iliac endarterectomy Ilio-femoral endarterectomy, unilateral Renal endarterectomy, unilateral Renal endarterectomy, bilateral Coeliac endarterectomy 3353001 3353300 3353600 3353900 3354200 3354800 3354801 3354802 3354803 3355100 3355400 3530306 3530307 3530400 3530401 3530500 3530501 3530906 3530907 3530908 3530909 3531000 3531001 3531002 3531003 3531004 3531005 3531200 3531201 3531500 3531501 Superior mesenteric endarterectomy Coeliac and superior mesenteric endarterectomy Inferior mesenteric endarterectomy Endarterectomy of extremities Extended endarterectomy of deep femoral artery Patch graft of artery using vein Patch graft of artery using synthetic material Patch graft of vein using vein Patch graft of vein using synthetic material Procurement of vein from limb for patch graft Endarterectomy in conjunction with arterial bypass to prepare site for anastomosis Percutaneous transluminal balloon angioplasty Open transluminal balloon angioplasty Percutaneous transluminal balloon angioplasty of 1 coronary artery Open transluminal balloon angioplasty of 1 coronary artery Percutaneous transluminal balloon angioplasty of 2 or more coronary arteries Open transluminal balloon angioplasty of 2 or more coronary arteries Percutaneous transluminal balloon angioplasty with stenting, single stent Percutaneous transluminal balloon angioplasty with stenting, multiple stents Open transluminal balloon angioplasty with stenting, single stent Open transluminal balloon angioplasty with stenting, multiple stents Percutaneous insertion of 1 transluminal stent into single coronary artery Percutaneous insertion of 2 or more transluminal stents into single coronary artery Percutaneous insertion of 2 or more transluminal stents into multiple coronary arteries Open insertion of 1 transluminal stent into single coronary artery Open insertion of 2 or more transluminal stents into single coronary artery Open insertion of 2 or more transluminal stents into multiple coronary arteries Percutaneous peripheral artery atherectomy Open peripheral artery atherectomy Percutaneous peripheral laser angioplasty Open peripheral laser angioplasty 3845619 3849700 3849701 3849702 3849703 3849704 3849705 3849706 3849707 3850000 3850001 3850002 3850003 3850004 3850300 3850301 3850302 3850303 3850304 3850500 Other intrathoracic procedures on arteries of heart without cardiopulmonary bypass Coronary artery bypass, using 1 saphenous vein graft Coronary artery bypass, using 2 saphenous vein grafts Coronary artery bypass, using 3 saphenous vein grafts Coronary artery bypass, using 4 or more saphenous vein grafts Coronary artery bypass, using 1 other venous graft Coronary artery bypass, using 2 other venous grafts Coronary artery bypass, using 3 other venous grafts Coronary artery bypass, using 4 or more venous grafts Coronary artery bypass, using 1 LIMA graft Coronary artery bypass, using 1 RIMA graft Coronary artery bypass, using 1 radial artery graft Coronary artery bypass, using 1 epigastric artery graft Coronary artery bypass, using 1 other arterial graft Coronary artery bypass, using 2 LIMA grafts Coronary artery bypass, using 2 RIMA grafts Coronary artery bypass, using 2 radial artery grafts Coronary artery bypass, using 2 epigastric artery grafts Coronary artery bypass, using 2 or more other arterial grafts Open coronary endarterectomy 3850700 3850800 3850900 3863700 9020100 9020101 9020102 9020103 9022900 9023000 E1050 E1051 E1052 E1059 E1150 E1151 E1152 E1159 E1451 E1452 E1459 G450 G451 G452 G453 G458 G459 G460 G461 G462 G463 G464 G465 G466 G467 G468 I110 I130 I132 I200 I201 I208 I209 I210 Left ventricular aneurysmectomy Left ventricular aneurysmectomy with patch graft Repair of ventricular septal rupture Re-operation for reconstruction of occluded coronary artery Coronary artery bypass, using 1 other material graft, not elsewhere classified Coronary artery bypass, using 2 other material grafts, not elsewhere classified Coronary artery bypass, using 3 other material grafts, not elsewhere classified Coronary artery bypass, using 4 or more other material grafts, not elsewhere classified Other endarterectomy Embolectomy or thrombectomy of other artery Insulin-dependent diabetes mellitus with peripheral circulatory complications, not stated as uncontrolled Insulin-dependent diabetes mellitus with peripheral circulatory complications, stated as uncontrolled Insulin-dependent diabetes mellitus with diabetic peripheral angiopathy with gangrene Insulin-dependent diabetes mellitus with other circulatory complications Non-insulin-dependent diabetes mellitus with peripheral circulatory complications, not stated as uncontrolled Non-insulin-dependent diabetes mellitus with peripheral circulatory complications, stated as uncontrolled Non-insulin-dependent diabetes mellitus with diabetic peripheral angiopathy with gangrene) Non-insulin-dependent diabetes mellitus with other circulatory complications Unspecified diabetes mellitus with peripheral circulatory complications, stated as uncontrolled Unspecified diabetes mellitus diabetes mellitus with diabetic peripheral angiopathy with gangrene) Unspecified diabetes mellitus diabetes mellitus with other circulatory complications Vertebro-basilar artery syndrome Carotid artery syndrome (hemispheric) Multiple and bilateral pre-cerebral artery syndromes Amaurosis fugax Other transient cerebral ischaemic attacks and related syndromes Transient cerebral ischaemic attack, unspecified Middle cerebral artery syndrome Anterior cerebral artery syndrome Posterior cerebral artery syndrome Brain stem stroke syndrome Cerebellar stroke syndrome Pure motor lacunar syndrome Pure sensory lacunar syndrome Other lacunar syndromes Other vascular syndromes of brain in cerebrovascular diseases Hypertensive heart disease with heart failure Hypertensive heart and renal disease with both (congestive) heart failure and renal failure Hypertensive heart and renal disease with both (congestive) heart failure and renal failure Unstable angina Angina pectoris with documented spasm Other forms of angina pectoris Angina pectoris, unspecified Acute transmural myocardial infarction of anterior wall I211 I212 I213 I214 I219 I220 I221 I228 I229 I230 I231 I232 I233 I234 I235 I236 I238 I240 I248 I249 I250 I2510 I2511 I2512 I2513 I253 I254 I255 I256 I258 I259 I460 I469 I50 I500 I501 I509 I600 I601 I602 I603 I604 I605 I606 I607 I608 I609 I610 Acute transmural myocardial infarction of inferior wall Acute transmural myocardial infarction of other sites Acute transmural myocardial infarction of unspecified site Acute subendocardial myocardial infarction Acute myocardial infarction, unspecified Subsequent myocardial infarction of anterior wall Subsequent myocardial infarction of inferior wall Subsequent myocardial infarction of other sites Subsequent myocardial infarction of unspecified site Haemopericardium as current complication following acute myocardial infarction Atrial septal defect as current complication following acute myocardial infarction Ventricular septal defect as current complication following acute myocardial infarction Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction Rupture of chordae tendineae as current complication following acute myocardial infarction Rupture of papillary muscle as current complication following acute myocardial infarction Thrombosis of atrium, auricular appendage, and ventricle as current complications following acute myocardial infarction Other current complications following acute myocardial infarction Coronary thrombosis not resulting in myocardial infarction Other forms of acute ischaemic heart disease Acute ischaemic heart disease, unspecified Atherosclerotic cardiovascular disease, so described Atherosclerotic heart disease, of unspecified vessel Atherosclerotic heart disease, of native coronary artery Atherosclerotic heart disease, of autologous bypass graft Atherosclerotic heart disease, of non-autologous biological bypass graft Aneurysm of heart Coronary artery aneurysm Ischaemic cardiomyopathy Silent myocardial ischaemia Other forms of chronic ischaemic heart disease Chronic ischaemic heart disease, unspecified Cardiac arrest with successful resuscitation Cardiac arrest, unspecified Heart failure congestive heart failure Left ventricular failure Heart failure unspecified Subarachnoid haemorrhage from carotid siphon and bifurcation Subarachnoid haemorrhage from middle cerebral artery Subarachnoid haemorrhage from anterior communicating artery Subarachnoid haemorrhage from posterior communicating artery Subarachnoid haemorrhage from basilar artery Subarachnoid haemorrhage from vertebral artery Subarachnoid haemorrhage from other intracranial arteries Subarachnoid haemorrhage from intracranial artery, unspecified Other subarachnoid haemorrhage Subarachnoid haemorrhage, unspecified Intracerebral haemorrhage in hemisphere, subcortical I611 I612 I613 I614 I615 I616 I618 I619 I630 I631 I632 I633 I634 I635 I636 I638 I639 I64 I650 I651 I652 I653 I658 I659 I660 I661 I662 I663 I664 I668 I669 I670 I672 I690 I691 I693 I694 I698 I700 I701 I7020 I7021 I7022 I7023 I7024 I708 I709 I7100 I7101 I7102 I7103 I711 Intracerebral haemorrhage in hemisphere, cortical Intracerebral haemorrhage in hemisphere, unspecified Intracerebral haemorrhage in brain stem Intracerebral haemorrhage in cerebellum Intracerebral haemorrhage, intraventricular Intracerebral haemorrhage, multiple localized Other intracerebral haemorrhage Intracerebral haemorrhage, unspecified Cerebral infarction due to thrombosis of pre-cerebral arteries Cerebral infarction due to embolism of pre-cerebral arteries Cerebral infarction due to unspecified occlusion or stenosis of pre-cerebral arteries Cerebral infarction due to thrombosis of cerebral arteries Cerebral infarction due to embolism of cerebral arteries Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries Cerebral infarction due to cerebral venous thrombosis, non-pyogenic Other cerebral infarction Cerebral infarction, unspecified Stroke, not specified as haemorrhage or infarction Occlusion and stenosis of vertebral artery Occlusion and stenosis of basilar artery Occlusion and stenosis of carotid artery Occlusion and stenosis of multiple and bilateral pre-cerebral arteries Occlusion and stenosis of other pre-cerebral artery Occlusion and stenosis of unspecified pre-cerebral artery Occlusion and stenosis of middle cerebral artery Occlusion and stenosis of anterior cerebral artery Occlusion and stenosis of posterior cerebral artery Occlusion and stenosis of cerebellar arteries Occlusion and stenosis of multiple and bilateral cerebral arteries Occlusion and stenosis of other cerebral artery Occlusion and stenosis of unspecified cerebral artery Dissection of cerebral arteries, non-ruptured Cerebral atherosclerosis Sequelae of subarachnoid haemorrhage Sequelae of intracerebral haemorrhage Sequelae of cerebral infarction Sequelae of stroke, not specified as haemorrhage or infarction Sequelae of other and unspecified cerebrovascular diseases Atherosclerosis of aorta Atherosclerosis of renal artery Atherosclerosis of arteries of extremities, unspecified Atherosclerosis of arteries of extremities with intermittent claudication Atherosclerosis of arteries of extremities with rest pain Atherosclerosis of arteries of extremities with ulceration Atherosclerosis of arteries of extremities with gangrene Atherosclerosis of other arteries Generalized and unspecified atherosclerosis Dissection of aorta, unspecified site Dissection of thoracic aorta Dissection of abdominal aorta Dissection of thoraco-abdominal aorta Thoracic aortic aneurysm, ruptured I713 I714 I715 I718 I739 I740 I741 I742 I743 I744 I745 I748 I749 Z951 Z955 Z958 Z959 Abdominal aortic aneurysm, ruptured Abdominal aortic aneurysm, without mention of rupture Thoraco-abdominal aortic aneurysm, ruptured Aortic aneurysm of unspecified site, ruptured Peripheral vascular disease, unspecified Embolism and thrombosis of abdominal aorta Embolism and thrombosis of other and unspecified parts of aorta Embolism and thrombosis of arteries of upper extremities Embolism and thrombosis of arteries of lower extremities Embolism and thrombosis of arteries of extremities, unspecified Embolism and thrombosis of iliac artery Embolism and thrombosis of other arteries Embolism and thrombosis of unspecified artery Presence of aorto-coronary bypass graft Presence of coronary angioplasty implant and graft Presence of other cardiac and vascular implants and grafts Presence of cardiac and vascular implant and graft, unspecified The ICD-10 AM codes listed above were back-mapped to the corresponding ICD 9 codes using the New Zealand Ministry of Health Excel spreadsheets of ICD 9 and 10 codes available at https://www.health.govt.nz/nz-health-statistics/data-references/mapping-tools/mapping-betweenicd-10-and-icd-9 The following ICD 9 codes were used to identify a hospitalisation for CVD or heart failure between 1 July 1993 and 30 June 2001: ‘A’ -Diagnosis codes: 412, 430, 431, 436, 438, 4111, 4131, 4139, 4148, 4149, 4230, 4275, 4280, 4281, 4289, 4292, 4295, 4296, 4353, 4358, 4359, 4370, 4376, 4378, 4379, 4400, 4401, 4408, 4409, 4411, 4413, 4414, 4415, 4416, 4439, 4440, 4441, 4449, 25070, 25071, 36234, 40291, 40491, 40493, 41011, 41041, 41071, 41081, 41091, 41181, 41189, 41400, 41401, 41402, 41403, 41411, 41419, 42971, 42979, 43300, 43310, 43320, 43330, 43380, 43390, 43391, 43400, 43401, 43411, 43490, 43491, 44020, 44021, 44022, 44023, 44024, 44100, 44101, 44102, 44103, 44421, 44422, 44481, 44489 ‘O’-Operation/procedure codes: 3572, 3601, 3603, 3605, 3606, 3607, 3611, 3612, 3613, 3614, 3615, 3616, 3699, 3732, 3800, 3810, 3812, 3814, 3815, 3816, 3818, 3820, 3832, 3836, 3842, 3844, 3846, 3848, 3869, 3922, 3925, 3926, 3928, 3929, 3952, 3956, 3957, 3959, 3999 ‘V’-Supplementary classification/health factors: V434, V4581, V4582 Appendix 2: Categories of blood pressure lowering, lipid lowering, and antiplatelet/anticoagulant medications available as cardiovascular medications in New Zealand up to 31 December 2011 Blood pressure lowering medications ACE inhibitors, thiazides, beta-blockers, angiotensin II antagonists, calcium channel blockers, alpha blockers, centrally-acting agonists (clonidine and methyldopa), vasodilators (hydralazine only), potassium-sparing diuretics (amiloride only) Lipid lowering medications Statins, nicotinic acid, cholestyramine with aspartame, ezetimibe with simvastatin, colestipol hydrochloride, ezetimibe, acipimox, bezafibrate, gemfibrozil, clofibrate. Antiplatelet/antithrombotic medications Aspirin, clopidogrel, dabigatran, rivaroxaban, warfarin Appendix 3: Supplementary results eFigure 1: CVD medications dispensed at baseline (1 July 2006 – 31 December 2006) and follow-up (1 January 2007 - 31 December 2011) among 740 009 New Zealand residents aged 30– 44 years on 31 December 2006 without prior CVD or heart failure hospitalisations APL Antiplatelet and/or anticoagulant medications; BPL Blood pressure lowering medications; LL Lipid lowering medications The APL, BPL and LL medication categories were not exclusive (e.g. a person included in the LL category could also be included in the BPL and/or the APL categories). For each medication category, dispensing at least once between 1 July 2006 and 31 December 2006 (i.e. baseline) and at least once in each six month period between 1 January 2007 and 31 December 2011 (i.e. follow-up) was recorded. During follow-up, only those six month periods where each New Zealand resident was alive and CVD event-free for the entire six months were included. The mean length of follow-up was 5.0 years. eFigure 2: CVD medications dispensed at baseline (1 July 2006 – 31 December 2006) and follow-up (1 January 2007 - 31 December 2011) among 663 961 New Zealand residents aged 45– 59 years on 31 December 2006 without prior CVD or heart failure hospitalisations APL Antiplatelet and/or anticoagulant medications; BPL Blood pressure lowering medications; LL Lipid lowering medications The APL, BPL and LL medication categories were not exclusive (e.g. a person included in the LL category could also be included in the BPL and/or the APL categories). For each medication category, dispensing at least once between 1 July 2006 and 31 December 2006 (i.e. baseline) and at least once in each six month period between 1 January 2007 and 31 December 2011 (i.e. follow-up) was recorded. During follow-up, only those six month periods where each New Zealand resident was alive and CVD event-free for the entire six months were included. The mean length of follow-up was 4.9 years. eFigure 3: CVD medications dispensed at baseline (1 July 2006 – 31 December 2006) and follow-up (1 January 2007 - 31 December 2011) among 362 614 New Zealand residents aged 60-74 years on 31 December 2006 without prior CVD or heart failure hospitalisations APL Antiplatelet and/or anticoagulant medications; BPL Blood pressure lowering medications; LL Lipid lowering medications The APL, BPL and LL medication categories were not exclusive (e.g. a person included in the LL category could also be included in the BPL and/or the APL categories). For each medication category, dispensing at least once between 1 July 2006 and 31 December 2006 (i.e. baseline) and at least once in each six month period between 1 January 2007 and 31 December 2011 (i.e. follow-up) was recorded. During follow-up, only those six month periods where each New Zealand resident was alive and CVD event-free for the entire six months were included. The mean length of follow-up was 4.6 years. The proportions of person-years of follow-up where nil CVD medications or any CVD medications were dispensed do not add to 100% due to rounding. eTable 1:CVD medications dispensed during follow- up (1 January 2007- 31 December 2011) according to baseline dispensing (1 July 2006 – 31 December 2006) among 740 009 New Zealand residents aged 30-44 years on 31 December 2006 without prior CVD or heart failure hospitalisations People dispensed medications at baseline Medications Dispensed a n (% of total population) Person-time during follow-up Total personyears (mean personyears) Person-years dispensed medicationsb % Any LL BPL APL LL only 7 310 (1%) 35 889 (4.9) 71% 69% 13% 9% BPL only 20 020 (3%) 97 885 (4.9) 73% 9% 73% 6% APL only 2 095 (<1%) 10 192 (4.9) 36% 4% 8% 31% LL and BPL only 4 384 (1%) 21 177 (4.8) 84% 77% 82% 18% LL and APL only 628 (<1%) 3 042 (4.8) 72% 68% 20% 62% BPL and APL only 1 494 (<1%) 7 074 (4.7) 72% 14% 69% 58% LL and BPL and APL 2 013 (<1%) 9 605 (4.8) 72% 67% 69% 63% APL Antiplatelet and/or anticoagulant medications; BPL Blood pressure lowering medications; LL Lipid lowering medications a The medication categories considered at baseline were exclusive (e.g. a person included in the LL and BPL category was not dispensed APL medications). b The APL, BPL and LL medication categories considered during the follow-up period were not exclusive (e.g. a person included in the LL category could also be included in the BPL and/or the APL categories). For each category of medications, dispensing at least once in each six month period between 1 January 2007 and 31 December 2011 (i.e. follow-up) was recorded. eTable 2: CVD medications dispensed during follow- up (1 January 2007- 31 December 2011) according to baseline dispensing (1 July 2006 – 31 December 2006) among 663 961 New Zealand residents aged 45-59 years on 31 December 2006 without prior CVD or heart failure hospitalisations People dispensed medications at baseline Medications Dispensed a n (% of total population) Person-time during follow-up Total personyears (mean personyears) Person-years dispensed medications (not exclusive)b % Any LL BPL APL LL only 23 820 (4%) 115 991 (4.9) 82% 80% 15% 12% BPL only 72 011 (11%) 347 529 (4.8) 88% 14% 87% 11% APL only 4 512 (1%) 21 517 (4.8) 54% 13% 15% 47% LL and BPL only 24 535 (4%) 117 080 (4.8) 94% 88% 92% 21% LL and APL only 4 197 (1%) 20 075 (4.8) 86% 82% 21% 73% BPL and APL only 9 707 (1%) 45 451 (4.7) 91% 21% 89% 77% LL and BPL and APL 14 762 (2%) 68 120 (4.6) 93% 87% 91% 84% APL Antiplatelet and/or anticoagulant medications; BPL Blood pressure lowering medications; LL Lipid lowering medications a The medication categories considered at baseline were exclusive (e.g. a person included in the LL and BPL category was not dispensed APL medications). b The APL, BPL and LL medication categories considered during the follow-up period were not exclusive (e.g. a person included in the LL category could also be included in the BPL and/or the APL categories). For each category of medications, dispensing at least once in each six month period between 1 January 2007 and 31 December 2011 (i.e. follow-up) was recorded. eTable 3: CVD medications dispensed during follow- up (1 January 2007- 31 December 2011) according to baseline dispensing (1 July 2006 – 31 December 2006) among 362 614 New Zealand residents aged 60-74 years on 31 December 2006 without prior CVD or heart failure hospitalisations People dispensed medications at baseline Medications Dispenseda n (% of total population) Person-time during follow-up Total personyears (mean personyears) Person-years dispensed medications (not exclusive)b % Any LL BPL APL LL only 17 830 (5%) 84 705 (4.8) 88% 86% 20% 18% BPL only 69 428 (19%) 319 003 (4.6) 93% 15% 92% 18% APL only 6 219 (2%) 27 872 (4.5) 70% 15% 21% 64% LL and BPL only 32 033 (9%) 146 884 (4.6) 97% 90% 95% 26% LL and APL only 5 816 (2%) 26 572 (4.6) 93% 88% 25% 82% BPL and APL only 21 296 (6%) 93 740 (4.4) 96% 20% 94% 85% LL and BPL and APL 29 312 (8%) 129 125 (4.4) 97% 91% 95% 89% APL Antiplatelet and/or anticoagulant medications; BPL Blood pressure lowering medications; LL Lipid lowering medications aThe medication categories considered at baseline were exclusive (e.g. a person included in the LL and BPL category was not dispensed APL medications). b The APL, BPL and LL medication categories considered during the follow-up period were not exclusive (e.g. a person included in the LL category could also be included in the BPL and/or the APL categories). For each category of medications, dispensing at least once in each six month period between 1 January 2007 and 31 December 2011 (i.e. follow-up) was recorded.
