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The 3 main parts of The Circulatory system The Heart The Blood Vessels Blood The Heart Is a pump Actually it is TWO pumps One pump deals with blood to the lungs, the other pump deals with blood to the body. Heart is made of Cardiac Muscle The two sides are separated by a thick wall of muscle called the SEPTUM The blood for the two pumps is kept separate in mammals. Septum Fetal Heart circulation Because the fetus is not using its lungs, the blood is “shunted” between the right and left atria through a hole called the foramen ovale. This usually closes within the first days of birth. Babies who do not have the foramen ovale closed are born with a “hole in the heart” Structure of the Heart. Four chambers, 2 upper called ATRIA & 2 lower called VENTRICLES The Right side of the heart receives deoxygenated blood from the body via the superior and inferior vena cava. The Left side receives oxygenated blood from the lungs via the Pulmonary veins Valves of the Heart Between the right atria and right ventricle is the TRICUSPID valve Between the left atria and left ventricle is the MITRAL valve. SEMILUNAR valves are found at the base of the PULMONARY artery and AORTA. The purpose of the valves is to prevent blood flowing backwards. Leaking of these valves can result in a heart murmur Watch the heart valves at this link http://watchlearnlive.heart.org/CVML_Player.php?moduleSelect=an atom Path of Blood in heart https://www.youtube.com/watch?v=BEWjOC VEN7M (Pulmonary valve) (Aortic valve) (tricuspid valve) (Mitral valve) http://academic.kellogg.cc.mi.us/herbrandsonc/bio201_McKinley/table22-3_blood_flow_th.jpg Cardiac Cycle - Heart Beat. Phase 1 SYSTOLE – Contraction Occurs when the Ventricles contract, closing the AV Valves and opening the SL Valves to pump blood into two major vessels leaving the heart. Phase 2 DIASTOLE – Relaxation Occurs when the Ventricles relax, allowing the back pressure of the blood to close SL Valves and opening AV valves. https://www.youtube.com/watch?v=jLTdgrhpDCg Your blood pressure is recorded as two numbers. The systolic blood pressure (the “upper” number) tells how much pressure blood is exerting against your artery walls while the heart is pumping blood. The diastolic blood pressure (the “lower” number) tells how much pressure blood is exerting against your artery walls while the heart is resting between beats. Atrial Systole Ventricular Systole Ventricular Diastole Blood pressure activity Cardiac Output & Fitness Like all muscles, the heart needs exercise The volume of blood pumped out by the heart is known as the CARDIAC OUTPUT. Factors that affect cardiac output are heart rate and stroke volume Cardiac output = heart rate X stroke volume Stroke volume (SV) is the amount of blood pumped out of the heart (left ventricle - to the body) during each contraction measured in mL/beat (milliliters per beat). Average person data Stroke volume = 70mL Heart rate = 70 beats/minute Cardiac cycle = 70mL X 70beats/min = 4900mL/min There is a correlation between heart health and fitness Relationship between stroke volume, heart rate & and cardiac output Individual A Cardiac output Stroke Volume mL/beat Heart Rate Beats/min •C is exceptionally fit has a high stroke volume and maintain a low hear rate. 4900 70 70 •B is less fit •Regular cardiovascular exercise increases the resting stroke volume. B 4900 50 98 C 4900 140 35 D 9800 70 140 •Fitness is measured by how quickly the heart rate returns to the resting rate before exercise began. Pulse activity Types of Blood Vessels Arteries -Carry blood away from the Heart -The Aorta is the largest artery Veins -Carry blood to the Heart -Veins contain valves -The Vena Cava is the largest vein Capillaries -Known as the “Distribution Pipes” Arteries Thick, muscular, hollow tubes which are highly ELASTIC – allows them to DILATE (widen) and CONSTRICT (narrow) as blood is forced down them by the heart Arteries branch and re-branch, becoming smaller until they become small ARTERIOLES which are even more elastic. – Arterioles force blood into the capillaries (high pressure). Veins VENULES (very small veins) merge into VEINS which carry blood back to the heart (low pressure). The vein walls are similar to arteries but thinner and less elastic. Veins possess valves at intervals to prevent the backflow of blood as it moves against the force of gravity back to the heart. CAPILLARIES Distribute the nutrients and oxygen to the body's tissues (blood pressure) and remove deoxygenated blood and waste by diffusion. They are extremely thin, the walls are only one cell thick and connect the arterioles with the venules (blood cells travel single-file). No cell in the body is more than 2 cells away from a capillary Function of Blood Transport oxygen – oxyhemoglobin Transport nutrients: - glucose, amino acids, Transport wastes – CO2 , urea, water Transport hormones – adrenalin, sex hormones etc. Transport heat Clotting during injury Provide immune response: - white blood cells Blood is made up of: Plasma Blood is made up of: Cells The Composition of Blood The Plasma (Fluid) makes up 55%- 60% of the blood volume. The Solids (Cells) make up 40%- 45% of the blood volume. ERYTHROCYTES (red cells) • Made in the Bone Marrow and destroyed in the Spleen. • Live for about 120 days • Contain Hemoglobin (transports oxygen to body and CO2 to lungs) • Are Bi-concave discs • Have no nucleus Your normal RED BLOOD CELL COUNT or Hb is between 12 and 14, (some hospitals measure this as 120 to 140, both are correct, just different units used). Liver or Kidney disease causes RBC to be damaged or destroyed LEUKOCYTES (white cells) Help the body fight bacteria and infection. THROMBOCYTES (platelets) Your normal PLATELET COUNT is between 150 and 400 (Which is actually 150,000 to 400,000 per cubic millimetre of blood!!!) Platelets… are made in the bone marrow • • Concerned with blood clotting. Circulate in the blood for about 10 days then die. How much blood is in the average person? Enough to fill one or two one-gallon milk jugs. Blood accounts for about seven percent of human body weight, and its density is only slightly more than that of pure water. A man weighing 154 pounds (70 kilograms) would have about 5.5 quarts (5.2 liters) of blood. A woman weighing 110 pounds (50 kilograms) would have about 3.5 quarts (3.3 liters) of blood. How much blood can a human lose? An adult human can lose 10-15% without clinical damage. If one loses 30% it can be fatal (haermorraghic [shock due to loss of blood]). An "average" adult male has some 5 litres of blood. Sudden loss of 1/3 of his blood can be fatal. However if the lose rate is slow (say: 24 hours) he can lose as much as 2/3 of the blood with much risk (well documented). So it's not only the amount of blood that one is losing but, the rate one loses it. It's also a matter of maintaining the blood pressure. Interesting.... In one day, your blood travels nearly 12,000 miles. Your heart beats around 35 million times per year. Your heart pumps a million barrels of blood during the average lifetime -enough to fill three supertankers. Vascular System Problems Aneurysm Arteriosclerosis Atherosclerosis Varicose veins Anemia Aneurysm A fluid-filled bulge found in the weakened wall of an artery which may eventually rupture and lead to cell death (common cause of strokes) Arteriosclerosis Degeneration of blood vessel due to accumulation of fat deposits along the inner wall. Atherosclerosis Blood vessels thicken, harden, wind, and lose their elasticity Varicose Veins Weakening of the veins that causes blood to pool and vessels to bulge. Sickle Cell disease – RBC are not round but sickle shaped, (genetic mutation for assisting in Malaria prevention) results in blood cells being destroyed prematurely. More commonly associated with people of African decent. Anemia Reduction of blood oxygen due to low levels of hemoglobin or poor red blood cell production Normal Low Iron