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FINAL EXAMINATION JANUARY 2012 SEMESTER 1/13/34 ACADEMIC SESSION COURSE COURSE CODE DURATION FACULTY PROGRAMME LECTURER : : : : : CLINICAL MICROBIOLOGY II MLD 2223 2 HOURS 30 MINUTES BIOMEDICAL AND HEALTH SCIENCES DIPLOMA IN MEDICAL LABORATORY TECHNOLOGY : MR. MOHD AMIR ABDULLAH INSTRUCTIONS TO CANDIDATES This paper consists of three (3) sections: Section A – 30 questions (multiple choice questions) Section B – 3 questions (short answer questions) Section C – 3 questions (essay questions) Answer all questions in Section A and B and only two (2) questions in Section C. All answers of: Section A must be written in OMR objective paper provided. Section B and C must be written in answer booklet provided. The answer for each question must start on a new page. Candidates are NOT ALLOWED to bring any unauthorized items into the exam hall except with the permission of your invigilator. Do Not Open the Question Paper Until Instructed This Question Paper Consists of EIGHT (8) Printed Pages CONFIDENTIAL FBHS/MLD2223/JAN2013 SECTION A: OBJECTIVE QUESTIONS (30 MARKS) Choose ONE best statement to answer the questions. 1. A symbiotic relationship in which one species benefits from the association while the other species is harmed from the relationship is called (A) (B) (C) (D) parasitism mutualism opportunistic commensalism 2. Which of the following statements about host-microbes is TRUE? (A) (B) (C) (D) Bacterimia is presence of virus in the host blood. A host is any organism that harbors no other organism. Endemic is a disease that is always present in a population. In mutualism neither of the two species benefits from the relationship. 3. The study of factors and mechanisms of disease frequency and spread within a population is called (A) (B) (C) (D) endemic etiology epidemic epidemiology 4. Corynebacterium diphtheria can cause (A) (B) (C) (D) diphtheria pharyngitis tuberculosis whooping cough 5. Whooping cough is caused by (A) (B) (C) (D) Bordetella pertussis Staphylococcus aureus Streptococcus pyogenes Mycobacterium tuberculosis CONFIDENTIAL/2 FBHS/MLD2223/JAN2013 6. Which of the following statements about diptheria is INCORRECT? (A) (B) (C) (D) Infects the upper respiratory tract Transmitted by droplets or fomites The bacteria are Gram-negative rods Toxin inhibits protein synthesis of cells 7. Pyelonephritis is inflammation of the (A) (B) (C) (D) ureter urethra urinary bladder renal parenchyma 8. Classical symptoms of urinary tract infection is characterized by all of the following EXCEPT (A) (B) (C) (D) dysuria urgency diarrhea frequent urination 9. The following organism can cause urinary tract infection EXCEPT (A) (B) (C) (D) Bacillus cerues Escherichia coli Klebsiella pneumoniae Pseudomonas aeruginosa 10. Which of the following pair is MISMATCHED? (A) (B) (C) (D) Shigella – typhoid fever enteropathogenic Escherichia coli – traveler's diarrhea Helicobacter pylori – peptic ulcer and chronic gastritis Staphylococcus aureus – food poisoning due to enterotoxins A and D 11. Which of the following microbes can cause dysentery? (A) (B) (C) (D) Proteus mirabilis Salmonella enteric Neisseria gonorrhoeae Streptococcus pneumoniae CONFIDENTIAL/3 FBHS/MLD2223/JAN2013 12. All of the following refers to food poisoning EXCEPT (A) (B) (C) (D) cystitis can cause due to food poisoning. Vibrio cholerae infection can cause food poisoning. the symptom in food poisoning are abdominal cramps and diarrhea. stool culture is used to diagnosis the microbe involve in food poisoning. 13. Neisseria gonorrhoeae is characterized by all of the following EXCEPT (A) (B) (C) (D) cleaves IgA Gram-negative diplococci can caused proliferative infections the symptom of infection are painful urination and purulent discharge 14. Lymphogranuloma venereum is caused by (A) (B) (C) (D) Neisseria gonorrhea Treponema pallidum Haemophilus ducreyi Chlamydia trachomatos 15. Which of the following statements about sexually transmitted diseases is FALSE? (A) (B) (C) (D) Neisseria gonorrhoeae can cause Gonorrhea Syphilis cannot be spread from mother to fetus Young people who experiment with sex are at risk Papilloma virus can cause proliferative infections 16. Haemophilus ducreyi can cause (A) (B) (C) (D) AIDS hepatitis chancroid gonorrhea 17. Waterhouse-Friderichsen syndrome is a complication of (A) (B) (C) (D) Bordetella pertussis Chlamydia trachomatis Vibrio parahemolyticus Meningococcal meningitis CONFIDENTIAL/4 FBHS/MLD2223/JAN2013 18. The MOST COMMON bacteria that cause meningitis in children is (A) (B) (C) (D) Clostridium perfringins Pseudomonas aeruginosa Streptococcus pneumonia Calymmatobacterium granulomatosis 19. The following diagnosis are used to detect tuberculous meningitis EXCEPT (A) (B) (C) (D) sputum culture urine examination tuberculin skin testing cebro spinal fluid analysis 20. The following are symptoms of meningitis EXCEPT (A) (B) (C) (D) jaundice drowsiness neck stiffness sudden high fever 21. Staphylococcus aureus causes all of the following EXCEPT (A) (B) (C) (D) impetigo erysipelas carbuncles scalded skin syndrome 24. The following are diseases of bone or joint EXCEPT (A) (B) (C) (D) urethritis osteomyelitis reactive arthritis infection of prosthetic joints 25. The following organism can cause haematogenous osteomyelitis EXCEPT (A) (B) (C) (D) Salmonella typhi Staphylococcus aureus Streptococcus pyogenes Haemophilus influenzae CONFIDENTIAL/5 FBHS/MLD2223/JAN2013 26. Which of following diagnosis are use to detect osteomyelitis? (A) (B) (C) (D) pus culture urine examination feces examination cerebrospinal fluid analysis 27. The following are laboratory diagnosis acute Septic Arthritis EXCEPT (A) (B) (C) (D) ultrasound plain X-ray blood culture feces examination 28. Which of the following definition about a fever of unknown origin (FUO) is FALSE? (A) (B) (C) (D) Deformity with abdominal pain More than 3 weeks' duration of illness A temperature greater than 38.3°C (101°F) on several occasions Failure to reach a diagnosis despite 1 week of patient investigation 29. Fever of unknown origin (FUO) is caused by (A) (B) (C) (D) boil style neoplasms acne vulgaris 30. The following bacteria can cause fever of unknown origin (FUO) EXCEPT (A) (B) (C) (D) Neisseria meningitidis. Neisseria gonorrhoeae. Propionibacter granulosum. Mycobacterium tuberculosis. CONFIDENTIAL/6 FBHS/MLD2223/JAN2013 SECTION B: SHORT ANSWER QUESTIONS (30 MARKS) Answer ALL questions. 1. a. Differentiate between symptoms and signs. (4 Marks) b. Describe the process of disease development. (6 Marks) 2. a. Define meningitis. (1 Mark) b. Name the causal agent for meningococcal meningitis. (1 Mark) c. State THREE (3) clinical complications of the meningococcal disease. (3 Marks) d. Determine the laboratory diagnosis to detect microbes involved in meningitis. (5 Marks) 3. a. Describe laboratory diagnosis to detect pathogen that causes septic arthritis. (5 Marks) b. Explain the characteristic and types of Escherichia coli. (5 Marks) CONFIDENTIAL/7 FBHS/MLD2223/JAN2013 SECTION C: ESSAY QUESTIONS (40 MARKS) Answer TWO (2) questions only. Question 1 Describe about Tuberculosis. Discuss the potential pathogen that causes Tuberculosis, symptoms, clinical features and related laboratory diagnosis. (20 Marks) Question 2 Explain about food poisoning. Discuss the potential pathogens that cause food poisoning and related laboratory diagnosis. (20 Marks) Question 3 Discuss the pathogenesis, signs, symptoms, clinical features and laboratory diagnosis of syphilis. (20 Marks) END OF QUESTION PAPER CONFIDENTIAL/8