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海外教师主导的研究生全英文课程基本信息表 课程名称 生物化学 上课时间 12.2-12.18 上课地点 待定 Biochemical sciences study the structure of the individual complex molecules that make up all living organisms, as well as the impressive network of chemical processes that are the essence of life. Biochemists explore the molecular basis of how bacteria, algae and plants ‘eat’ incident solar radiation (sunlight) to produce sugar and carbohydrate reserves. Biochemistry helps us understand diseases of plants and animals in order to correct deficiencies through genetic engineering and new agro-chemicals and pharmaceuticals. As the foundation of the life sciences, biochemistry contributes more and more to the well-being of the world’s population and to society’s economic growth. 课程简介 This Biochemistry grad course will provide you with a solid grounding in biology, chemistry, molecular- and systems-biology. Throughout the course, you will have the opportunity to supplement your classroom learning with a significant amount of English discussion in small-group innovation teams. This course will allow you to become more acquainted with specialized techniques and high-performance equipment, preparing you to move on to the fields of modern biochemistry: proteomics, genomics, molecular biology, genetic engineering, integrated metabolism, structural biochemistry, protein engineering and molecular modeling. During the course, you even have the opportunity to contribute to the advancement of scientific knowledge by participating in cutting-edge problem analysis, brain-storming, innovation, research and invention as you complete a three-week long Innovation Research Project with some of the world’s leading researchers. Advanced training via Biochemistry can help you prepare for careers in industrial, pharmaceutical, agri-food, clinical or research laboratories. You can also choose to study medicine, law, business or go on to teaching or postdoctoral studies. By focusing this course on a variety of subjects, such as the analysis of detailed aspects of molecular structures and the study of the integration of metabolism in whole organismal systems, this broad, basic background helps prepare you for a number of different work environments: teaching and research in an academic setting; research and administration in the biotechnology or pharmaceutical industry; or health-related disciplines in the public or private sector. Students with undergraduate education in the Life Science areas are welcome to take this course for credit: entomology, animal models of human disease, bioenergetics and metabolism, cancer biology, crop improvement, developmental genetics, growth and development, host resistance, membrane proteins, molecular biology of plants, viruses, bacteria and parasites, molecular biopharming in transgenic plants, protein farming, molecular genetics, molecular therapeutics, nanotechnology, neuromuscular disease, obesity, oral vaccines, physical biochemistry, protein chemistry, protein structure-function relationships, proteomics, RNA metabolism, signal transduction, or structural biology, just to name a few. The course will consist of Lectures, Discussion Groups, Seminars, and Invention Trios. Teachers: Prof. Illimar Altosaar, University of Ottawa, CANADA Prof. Wei-Jun Yang, Zhejiang University, CHINA Dr. Jin-Shu Yang, Zhejiang University, CHINA 周次 1 2 Introduction to Biochemistry 2014-2020, Vision of the future Immunological defence mechanisms 3 Genomics 4 Biologics and biopharmaceutical industries 5 Lipids and Lipid-Protein Interactions 6 Organellar proteomics 教学日历 7 8 参考文献 教学内容 Systems biology: from oceans to vitamins Amino acid chemistry is back in vogue 备注 Protein engineering: Immunoglobulin structure-function relations adaptive and innate host-defence molecular drive, evolution (Kyoto Prize), synthetic organisms Or why Mitsubishi-Tanabe acquired Medicago Inc. recombinant protein expression systems, From Escherichia to Oryza Membranes, Lipid Transfer Proteins Case study of Tryptophan-rich domains proteomics and bioinformatics Opti-gest and trifluoroacetic acid hydrolysis. Virdi V, Coddens A, De Buck S, Millet S, Goddeeris BM, Cox E, De Greve H, Depicker A. 2013. Orally fed seeds producing designer IgAs protect weaned piglets against enterotoxigenic Escherichia coli infection. Proceedings of the National Academy of Sciences of the United States of America 110 (29): 11809-11814 DOI: 10.1073/pnas.1301975110 Afshar M, Gallo, Richard L. 2013. Innate immune defense system of the skin. Veterinary Dermatology 24 (1): 32-+ DOI: 10.1111/j.1365-3164.2012.01082.x Toyama BH, Savas JN, Park SK, Harris MS, Ingolia NT, Yates JR, Hetzer, MW. 2013. Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures. Cell 154 (5): 971-982 DOI: 10.1016/j.cell.2013.07.037 Diedrich JK, Pinto AFM, Yates JR. 2013. Energy Dependence of HCD on Peptide Fragmentation: Stepped Collisional Energy Finds the Sweet Spot. J of the American Society for Mass Spectrometry 24 (11): 1690-1699 DOI: 10.1007/s13361-013-0709-7 Anderson OD, Huo NX, Gu YQ. 2013. The gene space in wheat: the complete gamma-gliadin gene family from the wheat cultivar Chinese Spring. Functional & Integrative Genomics 13(2): 261-273 DOI: 10.1007/s10142-013-0321-8 Sabalza M, Vamvaka E, Christou P, Capell T. 2013. Seeds as a Production System for Molecular Pharming Applications: Status and Prospects. Current Pharmaceutical Design 19(31): 5543-5552. Pauly, Anneleen et al., 2013. Wheat (Triticum aestivum L. and T. turgidum L. ssp durum) Kernel Hardness: I. Current View on the Role of Puroindolines and Polar Lipids. Comprehensive Reviews in Food Science and Food Safety 12(4): 413 -426. De Buck S, Nolf J ,De Meyer T, Virdi V, De Wilde K, Van Lerberge E, Van Droogenbroeck B, Depicker A. 2013. Fusion of an Fc chain to a VHH boosts the accumulation levels in Arabidopsis seeds. Plant Biotechnology J 11 (8): 1006-1016. Pinheiro C, Sergeant K,Machado CM, Renaut J, Ricardo CP. 2013. Two Traditional Maize Inbred Lines of Contrasting Technological Abilities Are Discriminated by the Seed Flour Proteome. J Proteome Research 12 (7): 3152-3165 DOI: 10.1021/pr400012t. Nelson D, Cox MM. 2008. Lehninger’s Principles of Biochemistry, Fifth Edition. W.H. Freeman and Company, New York. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. 2008. Molecular Biology of the Cell, Fifth Edition. Garland Science, New York.