Download KBBE-2007-2-4-06

Proposals for integration with the 7th Framework Programme
The Second Call 2007 Call: FP7-KBBE-2007-2A
KBBE-2007-2-4-06: Protecting animal and human health from prions in food, feed and
environment
DEVELOPMENT OF AN INFORMATION THEORY APPROACH, FOR QUANTIFYING
GENE-ENVIRONMENT INTERACTIONS AS CANCER RISK FACTORS FOR
SPECIFIC INDIVIDUALS
Institute of Genetics and Cytology of the National Academy of Sciences of Belarus
Phone: (37517) 2841944
Fax: (37517) 2841917
E-mail: [email protected]
Address: 27 Akademicheskaya St., Minsk 220072, Republic of Belarus
Scientific adviser:
Prof. Dr.Sc. S.E.Dromashko
Members of team:
Ph.D. N.N.Chakova
Ph.D. student E.P.Mikhalenko
Student A.Yu.Kukharenko
Summary
Aim of the subproject: development of new bioinformatics method and software, based on an
information theory approach, for quantifying the role of major cancer risk factors for specific
individuals. Consortium addresses international issues in epidemiology of gene-environment
interactions involved in carcinogenesis to be focused on an information theory approach
development for solving the problem of the information theory estimation of major cancer risk
factors for specific individuals. The proposal is of system interdisciplinary level, including biology
(biological basis of carcinogenesis), ecology (technogenic impact on human) and computer science
(bioinformatics). As a result of the project new bioinformatics method and software will be
elaborated and used in the case of estimation of lung cancer risk factors.
Introduction
A concept of increasing knowledge of biological processes and mechanisms involved in
carcinogenesis is one of the general directions of the mankind existence and development. This
problem is impossible to be solved without creation of a new concept and approaches to the
prevention, early diagnosis and treatment of cancer. The general priorities in this field are as
follows:
 translating research for human health, especially in cancer;
 epidemiology of gene-environment interactions involved in carcinogenesis;
 reducing cancer's incidence and mortality and improving quality of life for patients.
An important problem in Europe, Russia and Belarus is the problem of pollution (heavy metals,
radionuclides, pesticides, etc.) of agrolandscapes, forests and settlements. Under these conditions
the number of diseases in cancer of several aetiology permanently increases. That is why it is
necessary to create new technologies of prevention, early diagnosis and treatment of cancer caused
by environmental technogenic impact.
As one of the ways for solving this problem on modern technologycal platform, we propose to use
information theory approach in order to develop an appropriate software for estimating geneenvironment interactions involved in carcinogenesis (as an example, a case of estimation of lung
cancer risk factors). Earlier we have developed an theory information approach to estimation of
post-Chernobyl effects (Dromashko S.E., Frenkel G.I., Dubovskoi B.O. Information logical
analysis in simulation of ecological and genetic consequences of the Chernobyl catastrophe. //
Acute and Late Consequences of Nuclear Catastrophes: Hiroshima-Nagasaki and Chernobyl: Proc.
Bel.-Jap. Symp., Oct. 3-5, 1994. – Minsk-Tokyo, 1995, p. 335-344) and of biodiversity genetic
problems (Dromashko S.E. Informational theory of ecological and technological impact modeling
on biodiversity’s genetic component. // Intern. Conf. “Biodiversity and Dynamics of Ecosystems in
North Eurasia”. August 21–26, 2000, Novosibirsk, Russia. – Novosibirsk, 2000, vol. 1, p. 152-154).
The proposal is of system interdisciplinary level, including biology (biological basis of
carcinogenesis), ecology (technogenic impact on human) and computer science (bioinformatics). As
a result of the project, new bioinformatics method and software will be elaborated and used in the
case of estimation of lung cancer risk factors.
Main part
Aim of the subproject: Development of new bioinformatics method and software, based on an
information theory approach, for quantifying the role of major cancer risk factors for specific
individuals.
Objective: Development of a information theory approach, for quantifying gene-environment
interactions as cancer risk factors for specific individuals.
Work plan:
Task 1. Adaptation of mathematical apparatus of information theory for solving tasks in geneenvironment interactions involved in carcinogenesis.
Task 2. Development of information theory software for quantifying the role of major cancer risk
factors in the case of gene-environment interactions.
Task 3. Collection of the database for Belarus patients suffering from lung cancer (GST and some
other genes; environmental contamination; specific cohorts, etc.).
Task 4. Verification of the method to be developed by example of lung cancer risk factors;
estimation of its compatibility with the database.
Deliverables
1. A software, based on information theory approach, for quantifying the role of major cancer risk factors
in the case of gene-environment interactions.
2. A new database for Belarus patients suffering from lung cancer (GST and some other genes;
environmental contamination; specific cohorts, etc.) as a pilot database for several cases of cancer.
Main publications
1. Dromashko S.E. Mathematical Modeling of Genetic Processes. Methodological Aspects. – Minsk, 1999.
– 200 p. (monograph, in Russian)
2. Dromashko S.E. Mathematical and Computer Models in Biology: Opinion of Geneticist. – Minsk, 2006.
– 167 p. (monograph, in Russian)
3. Dromashko S.E., Frenkel' G.I., Dubovskoi B.O. Application of information-logical approach to studies
of genetic systems // Rus. J. Genet. 1995. Vol. 31, No 1, p. 119-123
4. Dromashko S.E., Mats S.R., Frenkel' G.I. On the logical scheme and structure of an application program
package for genetic and statistical calculations // Rus. J. Genet. 1995. Vol. 31, No 9, p. 1122-1123
5. Dromashko S.E., Frenkel G.I., Dubovskoi B.O. Information logical analysis in simulation of ecological
and genetic consequences of the Chernobyl catastrophe. // Acute and Late Consequenсes of Nuclear
Catastrophes: Hiroshima-Nagasaki and Chernobyl: Proc. Bel.-Jap. Symp., Oct. 3-5, 1994. – MinskTokyo, 1995, p. 335-344
6. Dromashko S.E., Kvitko O.V., Pisarchik G.A. Effects of electric fields on Drosophila: Physical model,
physiological action and genetic consequences // Intern. Conf. on Radiation and Health: Proceedings. Beer Sheva, Israel, 1996, p. 102
7. Dromashko S.E., Kvitko O.V., Pisarchik G.A. Effects of electric field on Drosophila melanogaster //
Rus. J. Ecol. Eng. Trans. 1997. Vol. 28, No 4, p. 275
8. Panich I.I., Makeeva E.N., Dromashko S.E. CHEDIBASE – interdisciplinary searching and base for the
Chernobyl information. // EUROMAB VI: Proc. MAB Sci. Symp. "Use and Conservation of Biological
Resources". – Minsk, 1998, p. 194-203.
9. Dromashko S.E. Informational theory of ecological and technological impact modeling on biodiversity’s
genetic component. // Intern. Conf. “Biodiversity and Dynamics of Ecosystems in North Eurasia”.
August 21–26, 2000, Novosibirsk, Russia. – Novosibirsk, 2000, vol. 1, p. 152-154
10. Dromashko S.E., Gorbachev A.V., Makeyeva A.M., Panich I.I. To the elaboration of a scientific and
educational system for processing and spreading biological data via Internet // Using Technology in
Open and Distance Learning: Proc. 2nd Int. DETECH Workshop, Maribor, Slovenia, September 13-14,
2001. – Maribor, 2001, p. 203–208