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CANCER BIOLOGY & THERAPEUTICS
COURSE OBJECTIVE
To explain mechanisms that enhance cancer development and progression and translate
the discoveries for better diagnostics and interventions.
UNIT 1
FUNDAMENTALS OF CANCER BIOLOGY
9 Hrs.
Definition, Benign Tumors Vs. Malignant Tumors, Types of Cancer, Common Symptoms .Regulation of
Cell cycle, mutations that cause changes in signal molecules, effects on receptor, signal switches, Tumor
Suppression genes, modulation of cell cycle in cancer. Different forms of cancers.
UNIT 2
PRINCIPLES OF CARCINOGENESIS
9 Hrs.
Principles of Carcinogenesis I - Chemical Carcinogenesis, Metabolism of Carcinogenesis,
Natural History of Carcinogenesis, Targets of Chemical Carcinogenesis. Principles of
Carcinogenesis II Principles of Physical Carcinogenesis, X - Ray radiation - mechanism of
radiation Carcinogenesis.
UNIT 3
MOLECULAR CELL BIOLOGY OF CANCER
9 Hrs.
Oncogenes, Identification of Oncogenes, Retroviruses and Oncogenes, detection of
Oncogenes, Growth Factor and Growth Factor receptors that are Oncogenes. Oncogenes /
Proto Oncogene activity. Growth factors related to transformations. Cancer pathways.
UNIT 4
PRINCIPLES OF CANCER METASTASIS
9 Hrs.
Clinical significances of invasion, heterogeneity of metastatic phenotype, Metastatic
cascade, Basement Membrane disruption, Three-step theory of Invasion, Proteinases and
tumour cell invasion.
UNIT 5
DETECTION OF CANCER AND CANCER THERAPY
9 Hrs.
Detection of Cancers, Prediction of aggressiveness of Cancer, Advances in Cancer
detection. Different forms of therapy, Chemotherapy, radiation therapy, and Immuno therapy:
advantages and limitations. Challenges in cancer treatment. Case study of cancer Survivors.