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Course information: Molecular Biomedicine BB2290 (7.5 HP) Aim The aim of the course is to provide the students an overview of the use of molecular technologies in medicine. Invited lectures will present recent scientific achievements in infectious and complex diseases including cancer and stem cells. Ethical and social implications of molecular medicine are also part of the course. After completed course the students will be able to • describe current technological trends in medical applications • discuss research trends in different diseases • suggest suitable technological approach for a molecular investigation of a disease • participate in an scientific discussion relating to biomedicine • critically evaluate the results from scientific publications Syllabus The course is focused on the use of molecular technologies in biomedical research. The lectures will cover different areas of biomedicine and will include an introduction to the particular field and the current use of modern methods for analysis and detection of respective biomolecules. Experts in their specific field will hold the lectures. Prerequisites Introduction to biotechnology BB1010, Biochemistry BB1040, Cell biology BB1020, Molecular biotechnology BB1060, Bioinformatics DD2396 and Applied gene technology BB2250 Required reading Molecular Medicine (3rd edition), R.J. Trent published by Elsevier. ISBN 0-12-699057-3. Can be purchased at Akademibokhandel, Mäster Samuelsgatan 28 but best price through internet: bokfynd.nu and amazon.com available from 600 SEK/82 USD. Distributed handouts and review articles. Requirements for examination Master/Biotechnology students: Examination comprise of three parts A. Dictionary/Exam part I. Dictionary and the Abbreviations exam during the first week. There will be a 45 minutes written exam. 85% (17 of 20) of the answers need to be correct to pass the Pre-exam. Pass grade corresponds to 5 p extra points in the final exam. The extra points can only be used at first exam occasion (Oct10) and the first re-exam occasion (Jan11) B. Questions/Exam part II. All students are required to prepare three written questions prior to the lectures. Questions should be based on Internet searching (using the Keywords in the schedule; you may also prepare a question from the book chapter). The lecturer will respond to the questions during the 2nd lecture hour to the lecturer. Course responsible together with the lecturer will make a sub-selection of all the questions. The questions should be delivered in writing prior to the first lecture hour and should include your name. Questions should be prepared for at least 11 of 13 lectures. Note that questions of certain quality are required to be qualified. The course responsible will continuously communicate fail/accept questions. A pass grade will correspond to 10 p extra points in the final exam. The extra points can only be used at first exam occasion (Oct10) and the first re-exam occasion (Jan11). C. Written examination/Exam part III – based on the book, handouts and articles. Short essay questions worth 35 p. Summary: Maximum points 50p (grade A) Passed in Dictionary [5 p] + Questions [10 p] + Written exam [35 p] PhD students: Examination comprise of a Written Assignment (for a selected disease area) Coordinator Joakim Lundeberg ([email protected]) Location Lectures are held both at the AlbaNova University Center at Roslagstull, Rooms starting with FB/FA in the main building. For detailed directions see www.biotech.kth.se/contact.html Schedule: Molecular Biomedicine BB2290 (7.5 hp) L Date Time Room Lecturer Title/Content -> reference chapter 1. Tue 31/8 8-10 FB53 Joakim Lundeberg, KTH Introduction: Molecular biomedicine 2. Fri 3/9 10-12 FB32 Henrik Stranneheim, KTH DNA, RNA, genes and chromosomes Keywords: SNP, haplotypes, genomes, personalized medicine 3. Tue 7/9 15-17 FB52 Daniel Klevebring, KI The transcriptome Keywords: non-coding RNA, regulation, splice variants, ENCODE project, diagnostics 4. Thu 9/9 8-10 FB53 Magnus Bjursell, KI/KTH Complex disease Keywords: complex disease, environment, modeling, epigenetics, imprinting, copy-number variations, system biology 5. Thu 9/9 8-10 FB53 Dictionary/Abbreviations Exam (part I): Group A: 8.15 - 9.00 Group B: 9.15 – 10.00 6. Fri 10/9 10-12 FB53 Mathias Uhlen, KTH Ethics and legal issues Keywords: Declaration of Helsinki, informed consent, DNA testing, personalized medicine, patenting [Chapter 10] 7. Fri 17/9 8-10 FA32 Dan Grander, KI Cellular machinery Keywords: cancer, proliferation, apoptosis, senescence [Chapter 4] [Chapter 2+5] 8. Wed 22/9 8-10 FB52 Jan Albert, SMI/KI Viral infectious diseases/HIV Virus Keywords: retrovirus, HIV transmission, resistance, virus evolution [Chapter 8] 9. Thu 23/9 8-10 FB42 Lars Engstrand, SMI Bacterial Infectious Disease/Helicobacter pylori Keywords: microbiota, resistance, virulence, gastro intestine, 16S rRNA, evolution [Chapter 8] 10. Tue 28/9 8-10 FB52 Patrik Ståhl, KTH The genomics of cancer Keywords: multi hit theory, tumor, mutation, p53 tumor suppressor [Chapter 4 11. Fri 1/10 10-12 FA32 Anna Wedell, KI Mendelian traits/Genetic disease Keywords: karyotype, re-arrangements, inheritance, recessive, dominant, FISH [Chapter 3] 12. Tue 5/10 8-10 FA32 TBD 13. Fri 8/10 10-12 FB52 Mikaela Fridman, UU Therapy and gene delivery Keywords: vectors, antisense, RNAi, ribozymes, receptor targeting, therapeutic antibodies, scaffolds, biodistribution [Chapter 6] 14. Tue 14/10 15-17 FB42 Hanna Sabelström, KI Stem cells/Regenerative medicine Keywords: embryonic stem cells, adult stem cells, therapeutic cloning, reproductive cloning, reprogramming [Chapter 6] 15. Fre 15/10 8-12 FB52 Veronica Höiom, KI/KUS Complex genetic traits/ Keywords: Cancer susceptibility, Medical genetics, Genetic variants, LOD [Chapter 4] [Chapter 4] 16. Sat 23/10 9-13 FB52, FB53 Note: Re-exam January TBD Exam