Download L Date Time Room Lecturer Title/Content -> reference chapter

Course information: Molecular Biomedicine BB2290 (7.5 HP)
Aim
The aim of the course is to provide the students an overview of the use of molecular technologies in
medicine. Invited lectures will present recent scientific achievements in infectious and complex diseases
including cancer and stem cells. Ethical and social implications of molecular medicine are also part of the
course.
After completed course the students will be able to
• describe current technological trends in medical applications
• discuss research trends in different diseases
• suggest suitable technological approach for a molecular investigation of a disease
• participate in an scientific discussion relating to biomedicine
• critically evaluate the results from scientific publications
Syllabus
The course is focused on the use of molecular technologies in biomedical research. The lectures will cover
different areas of biomedicine and will include an introduction to the particular field and the current use of
modern methods for analysis and detection of respective biomolecules. Experts in their specific field will hold
the lectures.
Prerequisites
Introduction to biotechnology BB1010, Biochemistry BB1040, Cell biology BB1020, Molecular biotechnology
BB1060, Bioinformatics DD2396 and Applied gene technology BB2250
Required reading
Molecular Medicine (3rd edition), R.J. Trent published by Elsevier. ISBN 0-12-699057-3. Can be purchased
at Akademibokhandel, Mäster Samuelsgatan 28 but best price through internet: bokfynd.nu and
amazon.com available from 600 SEK/82 USD. Distributed handouts and review articles.
Requirements for examination
Master/Biotechnology students: Examination comprise of three parts
A. Dictionary/Exam part I. Dictionary and the Abbreviations exam during the first week. There will be
a 45 minutes written exam. 85% (17 of 20) of the answers need to be correct to pass the Pre-exam.
Pass grade corresponds to 5 p extra points in the final exam. The extra points can only be used at
first exam occasion (Oct10) and the first re-exam occasion (Jan11)
B. Questions/Exam part II. All students are required to prepare three written questions prior to the
lectures. Questions should be based on Internet searching (using the Keywords in the schedule;
you may also prepare a question from the book chapter). The lecturer will respond to the questions
during the 2nd lecture hour to the lecturer. Course responsible together with the lecturer will make a
sub-selection of all the questions. The questions should be delivered in writing prior to the first
lecture hour and should include your name. Questions should be prepared for at least 11 of 13
lectures. Note that questions of certain quality are required to be qualified. The course responsible
will continuously communicate fail/accept questions. A pass grade will correspond to 10 p extra
points in the final exam. The extra points can only be used at first exam occasion (Oct10) and the
first re-exam occasion (Jan11).
C. Written examination/Exam part III – based on the book, handouts and articles. Short essay
questions worth 35 p.
Summary:
Maximum points 50p (grade A)
Passed in Dictionary [5 p] + Questions [10 p] + Written exam [35 p]
PhD students: Examination comprise of a Written Assignment (for a selected disease area)
Coordinator
Joakim Lundeberg ([email protected])
Location
Lectures are held both at the AlbaNova University Center at Roslagstull, Rooms starting with FB/FA in the
main building. For detailed directions see www.biotech.kth.se/contact.html
Schedule: Molecular Biomedicine BB2290 (7.5 hp)
L
Date
Time
Room
Lecturer
Title/Content -> reference chapter
1.
Tue 31/8
8-10
FB53
Joakim Lundeberg, KTH
Introduction: Molecular biomedicine
2.
Fri 3/9
10-12
FB32
Henrik Stranneheim, KTH
DNA, RNA, genes and chromosomes
Keywords: SNP, haplotypes, genomes,
personalized medicine
3.
Tue 7/9
15-17
FB52
Daniel Klevebring, KI
The transcriptome
Keywords: non-coding RNA, regulation,
splice variants, ENCODE project,
diagnostics
4.
Thu 9/9
8-10
FB53
Magnus Bjursell, KI/KTH
Complex disease
Keywords: complex disease,
environment, modeling, epigenetics,
imprinting, copy-number variations,
system biology
5.
Thu 9/9
8-10
FB53
Dictionary/Abbreviations
Exam (part I):
Group A: 8.15 - 9.00
Group B: 9.15 – 10.00
6.
Fri 10/9
10-12
FB53
Mathias Uhlen, KTH
Ethics and legal issues
Keywords: Declaration of Helsinki,
informed consent, DNA testing,
personalized medicine, patenting
[Chapter 10]
7.
Fri 17/9
8-10
FA32
Dan Grander, KI
Cellular machinery
Keywords: cancer, proliferation,
apoptosis, senescence
[Chapter 4]
[Chapter 2+5]
8.
Wed 22/9
8-10
FB52
Jan Albert, SMI/KI
Viral infectious diseases/HIV Virus
Keywords: retrovirus, HIV transmission,
resistance, virus evolution
[Chapter 8]
9.
Thu 23/9
8-10
FB42
Lars Engstrand, SMI
Bacterial Infectious
Disease/Helicobacter pylori
Keywords: microbiota, resistance,
virulence, gastro intestine, 16S rRNA,
evolution
[Chapter 8]
10.
Tue 28/9
8-10
FB52
Patrik Ståhl, KTH
The genomics of cancer
Keywords: multi hit theory, tumor,
mutation, p53 tumor suppressor
[Chapter 4
11.
Fri 1/10
10-12
FA32
Anna Wedell, KI
Mendelian traits/Genetic disease
Keywords: karyotype, re-arrangements,
inheritance, recessive, dominant, FISH
[Chapter 3]
12.
Tue 5/10
8-10
FA32
TBD
13.
Fri 8/10
10-12
FB52
Mikaela Fridman, UU
Therapy and gene delivery
Keywords: vectors, antisense, RNAi,
ribozymes, receptor targeting,
therapeutic antibodies, scaffolds,
biodistribution
[Chapter 6]
14.
Tue 14/10
15-17
FB42
Hanna Sabelström, KI
Stem cells/Regenerative medicine
Keywords: embryonic stem cells, adult
stem cells, therapeutic cloning,
reproductive cloning, reprogramming
[Chapter 6]
15.
Fre 15/10
8-12
FB52
Veronica Höiom, KI/KUS
Complex genetic traits/
Keywords: Cancer susceptibility,
Medical genetics, Genetic variants, LOD
[Chapter 4] [Chapter 4]
16.
Sat 23/10
9-13
FB52, FB53
Note: Re-exam January TBD
Exam