Download Marco van den Top - University of Warwick

Hypothalamic control of energy homeostasis
Dr. Marco van den Top
Theme: Translational medicine
Neuroscience
My University of Warwick past:
2002:
PhD;
Biological Sciences
2002-2005: post doc; Biological Sciences
2005-2009: post doc; Medical School
World Health Organization (WHO)
WHO projects that by 2015:
-
2.3 billion adults will be overweight
more than 700 million will be obese.
Overweight and obesity lead to serious health consequences.
Risk increases progressively as BMI increases.
- Cardiovascular disease (mainly heart disease and stroke)
already the world's number one cause of death, killing 17 million people each year.
- Diabetes
which has rapidly become a global epidemic. WHO projects that diabetes deaths
will increase by more than 50% worldwide in the next 10 years.
- Musculoskeletal disorders
especially osteoarthritis.
Some cancers (endometrial, breast, and colon).
The Battle of the Bulge will the ARC triumph???
anti-obesity drugs
THE ARC IS THE MAJOR POINT OF INTERACTION IN
THE CNS FOR ALMOST ALL THESE DRUGS !!!
Techniques utilised to answer our Scientific
questions (Multi disciplinary approach)
Electrophysiology
Single-cell PCR
Int
-actin AGRP OX1R Ob-Rb
NPY
POMC OX2R GHSR -RT
200 bp
100 bp
Morphology
D
M
L
V
20 mV
0.3s
Immunohistochemistry
CART 55-102
Alexa 633
10m
20 M