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IFTVET 6th International Cooperation Summit Forum October 21-24, 2016 Curriculum & Standards II 课程标准的制订 Dr. Ron Rusay 罗纳德·卢塞 教授 Diablo Valley College, California USA 美国岱伯洛谷学院 加利福尼亚,美国 Curriculum & Standards II 课程标准的制订 Chemistry Topics & Activities linking STEM & Liberal Arts (STEAM) • Overarching themes that connect chemistry with Engineering Technology Arts/Humanities • Collaboration with Professor Ben Koo Tsinghua University i-Center OBJECTIVE: Using common, nascent student interests, apply non-science majors’ chemistry topics and activities to develop STEM and Liberal Arts competency DUE TUES-1525057/1525862 Connecting STEM Student Progression Integration and organization within the Hyperlibraries What might a 3 dimensional graphic of networked STEM topical connections look like? How to view interconnected networks? .... for example a mammal’s brain? A human’s brain? The ChemWiki Libretext’s pages?; world’sbrain social networks? A mesoscale portion of 19,000+ connectome of The a mouse (469 signals) Nature 508, 207–214 (10 April 2014) doi:10.1038/nature13186 Complementary Aspects: ABC School/ XLP & STEMwikis Shared Context Scalable Learning Process Data Collection and Analysis Tools ABC School/ XLP Example Creating Rich Learning Contexts Students Translated “Holacracy Constitution 4.1” to Chinese in 24 hours Done during their first week XLP-based orientation program The original text in English is 41 pages long http://toyhouse.cc/wiki/index.php/合弄制宪章4.1 They also used The same wiki knowledge repository Tailored Rich Learning Contexts using a Wide Variety of OER Materials Incorporated into an On-line Hybrid Course Lab only face-to-face meetings; Guided Reading-Viewing Questions http://chemconnections.org/general/chem106/ Student Centered Viewing Reading Doing Open Educational Resources (OER) Calendar Guide On-line Student Centered Viewing Reading Doing http://chemconnections.org/general/chem106/calendar-106-f16.html ChemWiki / Libretext in lieu of a commercial textbook $ 0.00 Direct Cost to Students On-line Student Centered Viewing Reading Doing Viewing/Reading Guided On-line In-course on-line 5-10 minute Topic Videos from several sources including the American Chemical Society (ACS) In-course Powerpoint: printable files with active links, embedded examples and questions (Followed-up with in-class, graded i-clicker questions taken from or modified from the Powerpoints) In-course & external ChemWiki/STEMwiki Web pages (Integrated conceptual/historical background and experimental procedures) Viewing Topic Videos (5-10 min. pre-class) Google Form with Guiding Questions http://chemconnections.org/ge neral/chem106/Powers of TenGuide.html https://www.youtube.com/wa tch?v=FSyAehMdpyI https://www.youtube.com/wat ch?v=NgD9yHSJ29I Viewing Topic Videos (5-10 min. pre-class) Google Form with Guiding Questions http://chemconnections.org/ge neral/chem106/Powers of TenGuide.html Viewing Topic Videos (5-10 min. pre-class) http://chemconnections.org//general/movies/Pizza-thermo%202.mp4 i-clicker QUESTION View the video and select the best statement for why you would only burn the top of your mouth and not your tongue. A) The cheese is hotter then the crust. B) The tongue is less sensitive; moves around. C)The cheese is at a higher temperature D)The specific heat of cheese is greater than starch E) The specific heat of starch is greater than cheese i-clicker Answer View the video and select the best statement for why you would only burn the top of your mouth and not your tongue. A) The cheese is hotter then the crust. B) The tongue is less sensitive. C)The cheese is at a higher temperature D)The specific heat of cheese is greater than starch E) The specific heat of starch is greater than cheese Viewing/Reading Guided On-line Example In-course Powerpoint: http://chemconnections.org/general/chem106/Chem%20Reactions%20&%20Eqs.2016f.htm (Followed-up with in-class, graded i-clicker questions taken from or modified from the Powerpoint, eg. Pizza Themochemistry) Chemical Reactions Combination (Synthesis) A+B C H2 (g) + O2 (g) H2O (g) Balancing/ Stoichiometry (Conservation of Atoms): 2H2 (g) + O2 (g) 2 H2O (g) https://www.youtube.com/watch?v=a6qGIMqDKwA i-clicker i-clicker Viewing/Reading Guided On-line http://chemconnections.org/general/chem106/Solutions-2016.pdf http://chemconnections.org/general/chem106/Tech%20Prep/DNA-2016.html (Threaded conceptual & historical background with experimental procedures) Viewing/ Reading / Doing Integrated Activities • Building Vocabulary / Using a Wiki • Experiments paralleling course topics & concepts • Interactive Simulations: PhET & ChemCollective • Molecular Modeling: Molview •Web/ Library Research and Writing: Global Warming & Your Carbon Footprint: Capstone Writing/Peer Review Project (CPR) Viewing/ Reading / Doing Building Vocabulary / Using a Wiki Students build vocabulary from Powerpoint & Web page content searching ChemWiki/STEMwiki core topics and library, on-reserve, textbook references. Search results are posted on in-course ChemWiki pages as graded assignments. Viewing/ Reading / Doing Experiments http://chemconnections.org/general/chem106/Tech%20Prep/DNAexp%202016.pdf http://chemconnections.org/general/chem106/Tech%20Prep/DNA-2016.html Viewing/ Reading / Doing Interactive Simulations http://phet.colorado.edu/ https://phet.colorado.edu/sims/html/ph-scale/latest/ph-scale_en.html Viewing/ Reading / Doing Interactive Simulations http://phet.colorado.edu/ http://chemconnections.org/general/chem106/Acids%20and%20Bases-WKS-2016.pdf Shapes of Molecules View: What is the shape of a molecule? George Zaidan and Charles Morton https://www.youtube.com/watch?v=Jq_Ca-HKh1g Molecular Shapes Molecular Models for C, H, N, O Fundamental repeating shapes found in every biological molecule C =black H = gray N = blue O = oxygen pink = generic atom Viewing/ Reading / Doing Molecular Modeling http://molview.org/ http://chemconnections.org/general/chem106/VSEPR-Chem%20106%20form-a.pdf Polarity & Physical Properties Ozone and Water 0.1278 nm • • Resultant Molecular Dipoles > 0 Solubility: Polar molecules that dissolve or are dissolved in like • molecules • The Lotus flower Water & dirt repellancy: solubility? The “Lotus Effect” Biomimicry Wax Water not only dissolves some dirt, but attracts and removes it like a snowball rolling downhill. Lotus petals have micrometer-scale roughness, resulting in water contact angles up to 170° The “Lotus Effect” Biomimicry Isotactic polypropylene (i-PP) melted between two glass slides and subsequent crystallization provided a smooth surface. Atomic force microscopy tests indicated that the surface had root mean square (rms) roughness of 10 nm. A) The water drop on the resulting surface had a contact angle of 104° ± 2 B) the water drop on a superhydrophobic i-PP coating surface has a contact angle of 160°. Science, 299, (2003), pp. 1377-1380, H. Yldrm Erbil, A. Levent Demirel, Yonca Avc, Olcay Mert http://www.sciencemag.org/cgi/content/full/299/5611/1377/DC1 SC-0735 Nitisinone Orfadin CAS № 104206-65-7 Plant Natural Product Leptospermone http://chemconnections.org/organic/chem298/bottlebrush.html Molecular Biomimicry SC-0735 Nitisinone Orfadin CAS № 104206-65-7 Viewing/ Reading / Doing Molecular Modeling http://molview.org/ http://chemconnections.org/general/chem106/VSEPR-Chem%20106%20form-a.pdf Amino Acids Legos of Chemical Biology Amino acids contain carbon, hydrogen, oxygen, and nitrogen, which resemble the following shapes & structural components •20 different amino acids are encoded by the genetic code, which is archived in DNA. •Hundreds of amino acids link together with amide (peptide) bonds to form proteins, which are the machinery for the chemistry of life. •There are less than 20,000 total proteins produced from humans’ entire genome, each coded by a specific gene in DNA’s ~3 billion genetic bases. Periodic Table: Global Standard Proteins: Indispensible Biopolymers Acetylcholinesterase (ACE) ACE, an enzyme, which catalyzes a key reaction in a repetitive biochemical cycle that is crucial to neurological and physiological functions in humans…. and insects among others. 4,496 atoms; 4,404 bonds 574 amino acid residues Protein Receptors & Small Molecules Acetylcholinesterase Enzymes have receptors for small molecules that only have the right shape, which bind with the protein and chemically react. http://chemconnections.org/general/movies/richard.mpg SC-0735 Nitisinone Orfadin CAS № 104206-65-7 Shapes & Interactions (http://molview.org) HPPD : SC-0735 4-Hydroxy Phenyl Pyruvate Dioxygenase https://en.wikipedia.org/wiki/4-hydroxyphenylpyruvate_dioxygenase_inhibitor Detecting stuff we cannot see: the Sense of Smell Models, Theories & Interactions HPPD:SC-0735 / Odorants & Your Nose Structure-Odor Relationships Karen J. Rossiter, Chem. Rev., 1996, 96, 3201-3240 Historical view of a few smell receptors. 4 October 2004 The Nobel Assembly at Karolinska Institutet has today decided to award The Nobel Prize in Physiology or Medicine for 2004 jointly to Richard Axel and Linda B. Buck for their discoveries of "odorant receptors and the organization of the olfactory system" Shapes & Interactions: Mirror Images & Smell S-(+)-d- S-(+)-δ-caraway R-(-)-l- R-(-)-ι-spearmint http://chemconnections.org/organic/chem226/Labs/Smell/ChemComm.html From the late 1950s – early 1960s more than 10,000 children in 46 countries were born with deformities caused by the S-(-) enantiomer. chiral carbon atom 2016 Bioengineering: Structural Materials & Molecules Bacteria & Yeast Healing Concrete http://heronjournal.nl/56-12/1.pdf 2016 Bioengineering: Artemisinin Bacteria, Yeast & Chemical Synthesis Chinese Wormwood (Artemisia annua) & Malaria DUE TUES-1525057 1865 DNA: Genetics & Genomics Timelines Gregor Mendel (1822-1884) https://www2.edc.org/weblabs/Mendel/MendelMenu.html 1953 DNA: Molecular Discovery X-Ray Crystal Structure http://info.bio.cmu.edu/courses/03231/ProtStruc/ProtStruc.htm β-DNA: Rosalind Franklin 46 Å 12 base sequence http://molvis.sdsc.edu/pdb/dna_b_form.pdb 1975 Restriction Enzymes / Recombinant DNA Berg, Boyer, Cohen, and many others http://nar.oxfordjournals.org/content/early/2013/10/18/nar.gkt990.full 1989 PCR: Polymerase Chain Reaction Kary Mullis, Cetus-Chiron-Roche, Emeryville https://www.dnalc.org/resources/3d/19-polymerase-chain-reaction.html APPLICATIONS: Transgenic (GM: Genetically Modified) Crops 2001 Golden Rice http://www.goldenrice.org/ Hunan Study 2008 Golden Rice Paper 2012 Patents for Humanity Awards 2015 Transgenic Crops Genetically Modified Organisms (GMOs) http://www.greenpeace.org/international/Global/international/publications/agric ulture/2013/458%20-%20Golden%20Illusion-GE-goldenrice.pdf http://www.i-sis.org.uk/rice.php 2012 Genome Editing / CRISPR-Cas9 https://www.youtube.com/watch?v=2pp17E4E-O8 https://www.youtube.com/watch?v=SuAxDVBt7kQ Genetic Fingerprinting 1985 2016 •Forensics •Paternity •Military-ID •Food •Wine •Anthropology •Medical Diagnosis http://science.sciencemag.org/content/sci/351/6278/1133.full.pdf