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CSHL: http://www.cshl.org/ WSBS: http://www.cshl.edu/gradschool/ SUNY http://www.cshl.org/public/grad_SB.html Chancelor's Message Biology in the New Millennium http://www.cshl.edu/gradschool/chancellor.html Chancelor's Message Biology in the New Millennium In 1948, when I first spent a summer at the Cold Spring Harbor Laboratory, the big question to be solved was the nature of the gene and how it functioned. At that time, many scientists believed it would take many decades to come to grips with the essence of the gene at the chemical level. But the double helix with all of its molecular splendor and simplicity suddenly emerged in the spring of 1953. The search for the molecular identity of the gene was over. Our subsequent efforts in the 20th century led us beyond the structure of DNA to the genetic code, recombinant DNA technology, DNA sequencing, RNA splicing, oncogenes, tumorsuppressor genes, signal transduction pathways, and the molecular dissection of the cell cycle. The human genome is now complete and soon will be those of the mouse, the rat, the chimpanzee, the dog, and the chicken. Even earlier the complete DNA sequences of the worm Caenorhabditis elegans, the fly Drosophila melanogaster, and the plant Arabidopsis thaliana were worked out. By now establishing the DNA sequence for any organism – and the pinpointing of most of its genes and their chromosomal locations – is an achievable, predictable task limited only by the monies at our disposal. Now we need to understand how these instruction books work. In particular, we need to find out how the now seemingly somewhat less than 25,000 human genes are used. Though many scientists at the beginning of the 20th century saw the need for vital forces outside the laws of physics and chemistry, virtually all biologists now believe that not only development but human behavior and personality as well as, say, recognizing a familiar face can all eventually be explained in terms of molecular interactions and cell function. Much, much important science remains to be done. Understanding how variations in our individual genetic instruction books make each human so unique will go on long into this new century and the ones that follow. In the meantime pharmaceutical and biotech companies will use this new knowledge in ever-expanding practical ways. And here, as well as at more medically oriented research institutions, we will continue to identify new gene mutations that cause diseases like cancer. Our main task, however, remains understanding how key organisms function when all their genes have the right instructions. There remains nothing more important than understanding life. Library Cold Spring Harbor Laboratory: http://library.cshl.edu/ Open 24 hours to CSHL staff with PIN Service available 8am to 9pm Monday - Friday 10am to 6 pm Saturday Journals CSHL Journal List searchable list for journals and seriesboth print and online. NEW Use LinkOut to see CSHL full-text journals on PubMed JSTOR backfiles of selected titles Table of Contents of current journal issues Set up Alerting Services Request an article not owned by CSHL (Interlibrary Loan) Recommend a journal to add to our collection. Books WebCat -CSHL Library Collection Catalog books and journals NEW Who's Who in Stem Cell Research (Summer 2004 Edition) Full-text Books ONLINE o Current Protocols o Current Protocols o Current Protocols o Current Protocols o Current Protocols o Current Protocols o Current Protocols o Current Protocols in in in in in in in in Bioinformatics Cell Biology Cytometry Human Genetics Immunology Molecular Biology Neuroscience Nucleic Acid Chemistry o o o o o o o Current Protocols in Protein Sciences Encyclopedia of Life Sciences Oxford English Dictionary ONLINE Wiley InterScience Molecular Biology Collection 55 titles Wiley InterScience Medical Sciences Collection 56 titles Wiley InterScience Pharmaceutical Medicine Collection 29 titles Listing of Free E-Books online How to cite Current Protocols Online Borrow a book CSHL doesn't have. Suggest a book for purchase Databases (see subject guide for complete list) Agricola (via USDA) BioKnowledge Library from Proteome (information about CSHL access) BIOSIS via OVID gateway (password required, please e-mail Ellen [email protected], for further information) CANCERLIT, please use National Cancer Institute site. ENTREZ cross-database search New from NLM - searches 20 databases, including PubMed. Faculty of 1000 (information for first time CSHL users) FirstSearch from OCLC (includes ERIC for education, MEDLINE, and WorldCat for books) Index Catalogue of the Library of the Surgeon-General's Office (1892-1961) - books and articles ISI Highly Cited.com NEW - Lising of highly cited authors in science throughout the world Journal Citation Reports JSTOR (search for older articles in select journals) MEDLINE (via OVID) Novel: New York Online Virtual Electronic Library - provided by the New York State Library o Gale Databases (Custom newspapers, New York State Newspapers, Health Reference Center Academic, Business and Company Resource Center, etc.) For remote access instructions, go to Remote Gale Databases o Ebsco Databases (Full text Magazines, General Science Collection, Searchasaurus, EBSCOhost Espanol, etc.) For Remote Access instructions, go to Remote Ebsco Databases OVID gateway for alerting services and other databases (password required, please e-mail Ellen [email protected], for further information) PsycINFO (via OVID) PubMed Now back to mid-1950s ScienceDirect (search for articles in Elsevier journals) Web of Knowledge (Science Citation Index) IMPORTANT INFORMATION for those who use Google instead of PubMed when looking for an article: Please read Just Because It's Indexed Doesn't Mean You'll Find It You may be missing crucial information! Suggest a database Other Library Resources and Services Interlibrary Loan Request Form Use of Canon Color Copier/Networked Printer Library Staff CSHL Library Links to the WWW Reference Sources Online - dictionaries, encyclopedias, New York information, etc. Protocols Science Jobs Model Organisms MORE Archives Cold Spring Harbor Laboratory Archives History of the CSHL Carnegie Library Training Requesting a hands-on class for Library databases and services Computer training courses (in conjunction with IT department) National Library of Medicine: http://www.nlm.nih.gov National Institut of Health: http://www.nih.gov/