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Chancelor's Message Biology in the New Millennium
http://www.cshl.edu/gradschool/chancellor.html
Chancelor's Message
Biology in the New Millennium
In 1948, when I first spent a summer at the
Cold Spring Harbor Laboratory, the big
question to be solved was the nature of the
gene and how it functioned. At that time,
many scientists believed it would take many
decades to come to grips with the essence of
the gene at the chemical level. But the
double helix with all of its molecular splendor and simplicity
suddenly emerged in the spring of 1953. The search for the
molecular identity of the gene was over.
Our subsequent efforts in the 20th century led us beyond the
structure of DNA to the genetic code, recombinant DNA
technology, DNA sequencing, RNA splicing, oncogenes, tumorsuppressor genes, signal transduction pathways, and the molecular
dissection of the cell cycle. The human genome is now complete
and soon will be those of the mouse, the rat, the chimpanzee, the
dog, and the chicken. Even earlier the complete DNA sequences of
the worm Caenorhabditis elegans, the fly Drosophila
melanogaster, and the plant Arabidopsis thaliana were worked out.
By now establishing the DNA sequence for any organism – and
the pinpointing of most of its genes and their chromosomal
locations – is an achievable, predictable task limited only by the
monies at our disposal.
Now we need to understand how these instruction books work. In
particular, we need to find out how the now seemingly somewhat
less than 25,000 human genes are used. Though many scientists at
the beginning of the 20th century saw the need for vital forces
outside the laws of physics and chemistry, virtually all biologists
now believe that not only development but human behavior and
personality as well as, say, recognizing a familiar face can all
eventually be explained in terms of molecular interactions and cell
function.
Much, much important science remains to be done. Understanding
how variations in our individual genetic instruction books make
each human so unique will go on long into this new century and
the ones that follow. In the meantime pharmaceutical and biotech
companies will use this new knowledge in ever-expanding
practical ways. And here, as well as at more medically oriented
research institutions, we will continue to identify new gene
mutations that cause diseases like cancer. Our main task, however,
remains understanding how key organisms function when all their
genes have the right instructions.
There remains nothing more important than understanding life.
Library
Cold Spring Harbor Laboratory:
http://library.cshl.edu/
Open 24 hours to CSHL staff with PIN
Service available 8am to 9pm Monday - Friday
10am to 6 pm Saturday
Journals
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CSHL Journal List searchable list for journals and seriesboth print and online.
NEW Use LinkOut to see CSHL full-text journals on PubMed
JSTOR backfiles of selected titles
Table of Contents of current journal issues
Set up Alerting Services
Request an article not owned by CSHL (Interlibrary Loan)
Recommend a journal to add to our collection.
Books
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WebCat -CSHL Library Collection Catalog books and journals
NEW Who's Who in Stem Cell Research (Summer 2004 Edition)
Full-text Books ONLINE
o Current Protocols
o Current Protocols
o Current Protocols
o Current Protocols
o Current Protocols
o Current Protocols
o Current Protocols
o Current Protocols
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Bioinformatics
Cell Biology
Cytometry
Human Genetics
Immunology
Molecular Biology
Neuroscience
Nucleic Acid Chemistry
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Current Protocols in Protein Sciences
Encyclopedia of Life Sciences
Oxford English Dictionary ONLINE
Wiley InterScience Molecular Biology Collection 55 titles
Wiley InterScience Medical Sciences Collection 56 titles
Wiley InterScience Pharmaceutical Medicine Collection 29 titles
Listing of Free E-Books online
How to cite Current Protocols Online
Borrow a book CSHL doesn't have.
Suggest a book for purchase
Databases (see subject guide for complete list)
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Agricola (via USDA)
BioKnowledge Library from Proteome (information about CSHL access)
BIOSIS via OVID gateway (password required, please e-mail Ellen
[email protected], for further information)
CANCERLIT, please use National Cancer Institute site.
ENTREZ cross-database search New from NLM - searches 20 databases,
including PubMed.
Faculty of 1000 (information for first time CSHL users)
FirstSearch from OCLC (includes ERIC for education, MEDLINE, and WorldCat
for books)
Index Catalogue of the Library of the Surgeon-General's Office (1892-1961)
- books and articles
ISI Highly Cited.com NEW - Lising of highly cited authors in science
throughout the world
Journal Citation Reports
JSTOR (search for older articles in select journals)
MEDLINE (via OVID)
Novel: New York Online Virtual Electronic Library - provided by the New York
State Library
o Gale Databases (Custom newspapers, New York State Newspapers,
Health Reference Center Academic, Business and Company Resource
Center, etc.)
For remote access instructions, go to Remote Gale Databases
o Ebsco Databases (Full text Magazines, General Science Collection,
Searchasaurus, EBSCOhost Espanol, etc.)
For Remote Access instructions, go to Remote Ebsco Databases
OVID gateway for alerting services and other databases (password required,
please e-mail Ellen [email protected], for further information)
PsycINFO (via OVID)
PubMed Now back to mid-1950s
ScienceDirect (search for articles in Elsevier journals)
Web of Knowledge (Science Citation Index)
IMPORTANT INFORMATION for those who use Google instead of
PubMed when looking for an article:
Please read Just Because It's Indexed Doesn't Mean You'll Find It
You may be missing crucial information!
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Suggest a database
Other Library Resources and Services
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Interlibrary Loan Request Form
Use of Canon Color Copier/Networked Printer
Library Staff
CSHL Library Links to the WWW
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Reference Sources Online - dictionaries,
encyclopedias, New York information, etc.
Protocols
Science Jobs
Model Organisms
MORE
Archives
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Cold Spring Harbor Laboratory Archives
History of the CSHL Carnegie Library
Training
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Requesting a hands-on class for Library databases and services
Computer training courses (in conjunction with IT department)
National Library of Medicine:
http://www.nlm.nih.gov
National Institut of Health:
http://www.nih.gov/