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Transcript
EMERGING TECHNIQUES FOR DIAGNOSIS OF LUNG INFECTION Richard Malley, MD Division of Infectious Diseases Chidren’s Hospital Boston, USA Current diagnostic tests lack sensitivity for the identification of the bacterial etiology of pneumonia. Over the past 20 years, there have been numerous attempts to improve the sensitivity and accuracy of detection of bacterial pathogens in pneumonia, including, but not limited to, different sampling approaches, antibody-antigen complexes, or polymerase chain reaction. It is fair to state that these approaches have, in general, been disappointing. Surrogate markers for specific pathogens (e.g. Streptococcus pneumoniae) have been proposed, particularly in the context of developing countries, making use of conjugate vaccine studies as probes. Among pneumococcal diagnostics currently under investigation, quantitative real-time polymerase chain reaction of respiratory secretions, as well as urinary antigen detection and serological analyses, are all potential candidates for use in future clinical trials. The purpose of this talk will be to describe methodologies in diagnosis of bacterial pulmonary infections, with a particular emphasis on novel approaches to establish the etiology of infection.