Download CRP - Wellington ICU

CRP
26/8/10
PY Mindmaps
- discovered in 1930 by studying Streptococcus pneumoniae infection -> named for its ability
to bind to the somatic C-polysaccharide of such bacterial
- belongs to the family of pentraxins (calcium dependent ligand-binding plasma proteins)
Normal range
-
rapidly synthesised by the liver in proportional response to the inflammatory stimulus
90th percentile = 3mg/L
99th percentile = 10mg/L
t1/2 = 20 hours
Function
- proinflammatory activities
- anti-inflammatory activities
- has calcium-dependent binding properties and biological functions related to innate immune
response
Elevated by:
- bacterial infection
- fungal infection
- autoimmune diseases
- organ tissue necrosis
- severe trauma
- surgery
- neoplasias
- acute coronary syndromes (associated with poor prognosis)
- has been looked at also with risk of developing cardiovascular disease – measure of
vascular inflammation involved in atherogenesis
Clinical Utility
-
fast
easy
monitoring of inflammatory activity
use like temperature (response to therapy)
can recognise the onset of nosocomial infection in ICU with serial results
Jeremy Fernando (2011)