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Transcript
USF Available Technologies Differentially Expressed Gene Therapy for the Early Detection of LGL Leukemia R esearchers at the University of South Florida have ADVANTAGES: discovered a series of both known and novel gene sequences, which happen to be differentially ex- leukemia pressed in LGL leukemia. This technology addresses the use of these gene sequences as molecular markers and their possible utility as novel therapeutic targets for the disease. T-cell large granular lymphocyte (T-LGL) leukemia is a chronic human lymphoproliferative disorder associated with autoimmune disease. It is one of several types of chronic lymphocytic leukemia, and presents with enlarged Early Detection and treatment applications for LGL Advanced detection of the clinical triad of rheumatoid arthritis, neutropenia, and splenomegaly Enhanced gene therapy and therapeutic process for early detection of LGL leukemia and autoimmune disorders Advanced biological molecular marker applications using a combination of micro-array, RNase protection assays, and Northern Blot analysis lymphocytes with abundant pale cytoplasm containing conspicuous azurophilic granules (Figure 1). Autoimmune features are characteristic of this disease, and many of these patients present with the triad of rheumatoid arthritis, neutropenia, and an enlarged spleen. Early Detection and Treatment of LGL Leukemia The main indication for treatment of patients with T-LGL is recurrent infection due to severe neutropenia. Aggressive cases of T-LGL leukemia are usually treated with combination chemotherapy. Current research suggests that LGL leukemia is likely an antigen driven event. However, independent of the factors involved in the initiation of this disease, the final effect is the emergence of a lymphoproliferative disorder with characteristic allocations in a gene expression pattern. Using a combination of techniques, several genes have been identified which are differentially expressed in LGL leukemia and represent promising candidates for early diagnosis and treatment of LGL leukemia. Tech ID # 02A027 University of South Florida | Technology Transfer Office 813.974.0994 (office) | 813.974.8490 (fax) [email protected] http://www.usf.edu/research-innovation/pl/