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Adil N. Ahmad & Hammad Shaikh Final Year Medical Students UCL Infectious – Lower Respiratory Tract Infection Leading cause of death of children (<5) worldwide Accounts for 17% of under 5 deaths in Uganda Most common causative organisms are Streptococcus Pneumoniae and Haemophilus Influenzae Less common organisms include Staphylococcus Aureus, Neisseria Meningitis, Klebsiella, Cryptococcus, Pseudomonas Pneumonia is treatable with antibiotics and these deaths are preventable Fever Cough Difficulty in Breathing/Tachypnoea Subcostal/Intercostal recession/Tracheal Tug Chest Indrawing/Use of accessory muscles Areas dull to percussion Crackles on Auscultation Cyanosis/Low Oxygen Saturations Sputum Culture – Antibiotic sensitivities CBC/CRP CXR < 2 months = > 60 bpm 2 months – 1 year = > 50 bpm 1-5 years = > 40 bpm ABC Approach Oxygen Antibiotics as early as possible! Consider Nasogastric (NG) tube if patient is not feeding well Correct Dehydration – ORS/IV Maintenance Fluids Dry Mucous Membranes Sunken Eyes/Fontanelle Reduced Skin Turgor Irritability/Lethargy (GCS < 15/ BCS < 5) Cold Peripheries (consider shock) Pneumonia Severe Pneumonia ◦ Chest Wall Indrawing Very Severe Pneumonia ◦ ◦ ◦ ◦ Airway – grunting Cyanosis/Low Oxygen Saturations/Reduced GCS Poor feeding/drinking Poor Clinical Picture Benzylpenecillin ◦ 50,000 IU/kg qds Gentamicin ◦ 5 mg/kg OD Vitamin A ◦ 6-11 months – 100,000 IU ◦ 12-59 months – 200,000 IU Ceftriaxone 100 mg/kg OD ◦ If patient fails to improve after 48 hours OR ◦ If patient beings to deteriorate at any point Appropriate prescribing ◦ Good Clinical Outcome ◦ Short stay in Hospital (prevent Iatrogenic infection) ◦ Efficient use of resources Poor Prescribing ◦ ◦ ◦ ◦ Poor Clinical Outcome – including death Longer Stay in Hospital (further infections) Poor use of hospital resources Antibiotic Resistance Audit is a review of prescribing in accordance with clinical guidelines It attempts to improve clinical practice and therefore patient outcomes It is NOT a blame game To review patient notes to assess whether: ◦ Patients had been correctly diagnosed according to signs and symptoms ◦ Whether prescribing was appropriate ◦ Whether doses were given on time To come up with recommendations Patient files were reviewed of: ◦ Patients admitted between Friday 15th November, 2013 to Friday 22nd November 2013 ◦ Diagnosed with Pneumonia, Severe Pneumonia or Very Severe Pneumonia ◦ Many had concurrent diagnoses (eg. Malaria) ◦ Some gaps due to personal injury – Thank you to Dr. Rippon for collecting a significant amount of data Sample size = 14 patients Were Patients Prescribed the Correct Antibiotic? 6 43% Yes 8 57% No Prescribing Ceftriaxone immediately when there is no indication before trying Penicillin and Gentamicin Were Patients Prescribed Correct Antibiotic Dose? 2 14% Yes 12 86% No Dose of Gentamicin and Penicillin IV not being done according to weight. Were the Antibiotics Given on Time? 5 36% Yes 9 64% No First dose usually given on time, but the follow up doses are sporadic In these cases: ◦ 1 dose delay of less than 6 hours ◦ 2 doses delayed by 12-24 hours ◦ 2 doses delayed by more than 24 hours Were Patients Prescribed Vitamin A when Appropriate? 7 7 50% 50% Yes No Of the 7 Inappropriate Occasions 2 29% 5 71% Given to < 6 months Not given to 6-59 month old Was the Correct Dose of Vitamin A Given? 3 4 57% 43% Yes No Prescribing to children below 6 months or over 5 years Dosage not done by weight Child below 3rd Centile (Weight for Age)? 6 43% 8 57% Yes No Weighing scale not available in Emergency No WHO Growth Charts available Poor Legibility – we are all guilty! Drugs written up in Management Plans but not on Drug Chart – drugs not given. Poor communication between Nursing Staff and Doctors about stocks of drugs No signatures on drugs (accountability) Revise Guidelines Write in BLOCK CAPITALS on drug chart Ensure all drugs from clerking management plans are copied out Nursing staff to communicate when drug unavailable Have printed WHO Weight for Age Growth Charts in Emergency and Wards Have Weighing scales in Emergency and Wards Nurse-patient allocation Ward Organisation Early recognition of signs and symptoms Early Health seeking behaviour Good Hygiene – Handwashing to reduce spread of infection Immunisations Exclusive breastfeeding for 6 months Limited Medication Limited Oxygen Supply Only one saturation probe Clinical Officers often don’t stay at night leading to increased risk to patient care Low staffing levels Patient Admission times and dosage given Time of deaths ◦ Mortality much greater at night Dr. Vanessa Rippon Dr. Tenywa The Interns ◦ Dr. Acleo ◦ Dr. Paul ◦ Dr. James Nursing Staff