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Rabies, the Fury Virus Pathogenesis • Bite site • striated muscle cells • peripheral nervous system is exposed in neuromuscular spindles • exposed sensory nerve endings and motor end plates Pathogenesis (cont) • Neuronal infection (towards the center) • CNS • Brain and Salivary Glands Why it is so evasive • There may be very little virus and virus antigen delivered to evoke an immune response • There may be very little virus and virus antigen produced in muscle early in the infection and very little in the peripheral nerves and CNS . Why it is the fury disease • Virus enters the saliva an multiplies exponentially at the same time it causes a fury effect in the limbic system. End result • The virus enters the neocortex. – Causes the dumb stage – Death by respiratory distress Control • Immunization – currently spend 1 billion dollars in U.S. alone – looking for more effective drugs