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PD-1 Pathway, Flyer Interest in any of the products, request or order them at Bio-Connect. Bio-Connect B.V. Begonialaan 3a 6851 TE Huissen The Netherlands T NL +31 (0)26 326 44 50 F NL +31 (0)26 326 44 51 E [email protected] W www.bio-connect.nl T BE +32 (0)2 503 03 48 F BE +32 (0)2 503 03 27 PD-1 Pathway The binding of Programmed Cell Death Protein 1 (PD-1), Crystal Structure of the PD-1/PD-L1 complex. Image courtesy of www.rcsb.org; DOI: 10.1073/pnas.0712278105. a receptor expressed on activated T-cells, to its ligands, PD-1 Assay Kits PD-L1 immune Recent research has led to the emergence of promising responses. The PD-1 ligands are found on most clinical applications of PD-1 antagonists and antagonists cancers, and PD-1/PD-L interaction inhibits T cell activity to human disorders and diseases. BPS’s and allows cancer cells to escape immune surveillance. assay kits are the first commercially available assays The PD-1/PD-L pathway also is involved in regulating designed for screening small molecule inhibitors for drug autoimmune discovery. and PD-L2, negatively responses, making regulates these proteins promising therapeutic targets for multiple sclerosis, Catalog # Amount PD-L1:B7-1[Biotinylated] Inhibitor Screening Assay Kit 72026 96 rxns PD-1:PD-L1[Biotinylated] Inhibitor Screening Assay Kit 72003 96 rxns PD-1:PD-L2[Biotinylated] Inhibitor Screening Assay Kit 72004 96 rxns PD-L1 Inhibitor Screening Assay Kit 72005 96 rxns PD-L2 Inhibitor Screening Assay Kit 72006 96 rxns inhibitor screening assays, and drug discovery. BPS is the only company to offer biotinylated versions of PD-1, PD-1:PD-L2 TR-FRET Assay Kit 72012 384 rxns PD-1:PDL1 Homogenous Assay Kit 72014 384 rxns Catalog # Size arthritis, lupus, and type I diabetes, as well as a number of human cancers. BPS Bioscience is excited to announce the release of its products and services portfolio for research of the PD-1 pathway. PD-1 Proteins BPS Bioscience provides an ever-growing portfolio of enzymes and kits suitable for enzymatic profiling, PD-L1 and PD-L2. Protein Assay Kit PD-1/PD-L Catalog # Amount 71106 100 µg Antibodies PD-1 (PDCD1), FLAG-tag 71115 100 µg Antibody Name PD-1 (PDCD1), Biotin-labeled 71109 50 µg PD-1 (CD274), Biotin-labeled, Mouse 71118 50 µg Anti-PD-L1 Neutralizing Antibody, Biotin-labeled 71214 50 µg PD-1 (CD279), Fc Fusion, Mouse 71116 PD-1 Neutralizing Antibody 71120 50 µg PD-L1 (CD274) Neutralizing Antibody 71213 50 μg PD-1 (PDCD1) 100 µg PD-L1 (CD274) 71104 100 µg PD-L1 (CD274), Biotin-labeled 71105 50 µg PD-L1 (CD274), FLAG-tag 71183 100 µg PD-L1 (CD274), Fc Fusion, Mouse 71117 100 µg PD-L2 (CD273) 71107 100 µg PD-L2 (CD273), Biotin-labeled 71108 50 µg PD-1, FLAG-Avi-His-tag 71198 50 μg PD-1 (Monkey), Fc Fusion 71158 100 μg PD-L1 (Monkey), Fc Fusion 71153 100 µg PD-L1 (Monkey), Fc Fusion, Biotinlabeled 71154 50 µg Als o av ailable: PD-1/PD-L screening and profiling services. Please contact us for details and a free quote. TThhee ##11 SSoouurrccee ffoorr AAccttiivvee EEnnzzyym meess Inhibition of PD-1-PD-L1 binding by the PD-1 Neutralizing antibody, Catalog #71120, measured using the using the PD-1:PD-L1[Biotinylated] Inhibitor Screening Assay Kit, Catalog #72003. 6044 Cornerstone Court West, Suite E San Diego, CA 92121 858.829.3082 ph 858.481.8694 fax www.bpsbioscience.com Rev. Jul 2015
